Protective neuroendocrine effects of environmental enrichment and voluntary exercise against social isolation: evidence for mediation by limbic structures

Watanasriyakul, W Tang; Normann, Marigny C; Akinbo, Oreoluwa I; Colburn, William J.; Dagner, Ashley; Grippo, Angela J.

doi:10.1080/10253890.2019.1617691

Cited by 17 publications

(12 citation statements)

References 66 publications

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“…VWR counteracted the development of social avoidance and anhedonia after chronic SD stress (Mul et al, 2018;Zhang et al, 2019). Likewise, VWR J o u r n a l P r e -p r o o f attenuated the increased neuroendocrine response induced by social isolation stress (Watanasriyakul et al, 2019) and counteracted the behavioral impairments induced by uncontrollable stress (Greenwood et al, 2003 andTanner et al, 2019). The relationship between stress and exercise is bidirectional, as Parra-Montes de Oca and coworkers ( 2019) have recently reported that chronic stress decreases the metabolic response to voluntary exercise characterized by the loss of white adipose tissue depots.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 88%

“…Physical exercise interacts with stress and neuroinflammation depending on the intensity. Several studies have observed that VWR reduces the levels of corticosterone and glucocorticoid receptors, attenuating the negative effects of chronic stress (Zheng et al, 2006;Ignácio et al, 2019;Lynch et al, 2019;Watanasriyakul et al al., 2019). The inhibition of the excess production of corticosterone can attenuate the inflammatory response of stress (Niraula et al, 2018).…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

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Voluntary wheel running protects against the increase in ethanol consumption induced by social stress in mice

Reguilón

Ferrer-Pérez

Ballestín

et al. 2020

Drug and Alcohol Dependence

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 88%

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Voluntary wheel running protects against the increase in ethanol consumption induced by social stress in mice

Reguilón

Ferrer-Pérez

Ballestín

et al. 2020

Drug and Alcohol Dependence

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“…Further exploration of electrophysiological properties, other plasticity markers, and stress interactions would be interesting for a more complete comparison. Again, the Fos results are conflicting in this region, with different studies finding that EE can increase 51,146,147 or decrease 60,142 Fos and delta-FosB responses to stress. CCO studies again demonstrate decreased metabolic capacity, and thus improved processing efficiency, in the prefrontal cortex 25,143,144 .…”

Section: Synaptic Plasticity and Activitymentioning

confidence: 94%

Differential impact of stress and environmental enrichment on corticolimbic circuits

Smail

Smith

Nawreen

et al. 2020

Pharmacology Biochemistry and Behavior

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Stress exposure can produce profound change in physiology and behavior that can impair health and well-being. Of note, stress exposure is linked to anxiety disorders and depression in humans. The widespread impact of these disorders warrants investigation into treatments to mitigate the harmful effects of stress. Pharmacological treatments fail to help many with these disorders, so recent work has focused on non-pharmacological alternatives. One of the most promising of these alternatives is environmental enrichment (EE). In rodents, EE includes social, physical, and cognitive stimulation for the animal, in the form of larger cages, running wheels, and toys. EE successfully reduces the maladaptive effects of various stressors, both as treatment and prophylaxis. While we know that EE can have beneficial effects under stress conditions, the morphological and molecular mechanisms underlying these behavioral effects are still not well understood. EE is known to alter neurogenesis, dendrite development, and expression of neurotrophic growth factors, effects that vary by type of enrichment, age, and sex. To add to this complexity, EE has differential effects in different brain regions. Understanding how EE exerts its protective effects on morphological and molecular levels could hold the key to developing more targeted pharmacological treatments. In this review, we summarize the literature on the morphological and molecular consequences of EE and stress in key emotional regulatory pathways in the brain, the hippocampus, prefrontal cortex, and amygdala. The similarities and differences amongst these regions provide some insight into stress-EE interaction that may be exploited in future efforts toward prevention of, and intervention in, stress-related diseases.

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“…To our knowledge, our study is the first to investigate changes in ΔFosB/FosB following transient post-weaning isolation, but there have been reports in other models of social isolation. Isolation for eight weeks on adult female prairie voles increased ΔFosB/FosB immunohistochemistry in the basolateral amygdala [8]. Interestingly, prolonged social isolation in adult mice decreases ΔFosB in the nucleus accumbens and increases susceptibility to the detrimental effects of social defeat stress [7].…”

Section: δFosb Expression Particularly In the Nucleus Accumbens Is Associated With Augmented Responses To Drugs Of Abuse Early Experimentmentioning

confidence: 96%

“…The copyright holder for this preprint (which this version posted June 5, 2020. ; https://doi.org/10.1101/2020.06.04.135517 doi: bioRxiv preprint Post-weaning social isolation and FosB/ΔFosB 4 ΔFosB/FosB induction has been studied in the context of rodent SI models, but, to our knowledge, not in models of post-weaning/adolescent isolation [7,8]. Here we assessed the expression of ΔFosB/FosB in the mPFC, hippocampus, and striatum, three regions involved in the behavioral response to stress, after exposure to a validated model of post-weaning isolation [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Post-weaning social isolation increases ΔFosB/FosB protein expression in sex-specific patterns in the prelimbic/infralimbic cortex and hippocampus in mice

Noback

Zhang

White

et al. 2021

Neuroscience Letters

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Social isolation is a growing public health concern across the lifespan. Specifically, isolation early in life, during critical periods of brain development, increases the risk of psychiatric disorders later in life. Previous studies of isolation models in mice have shown distinct neurological abnormalities in various regions of the brain, but the mechanism linking the experience of isolation to these phenotypes is unclear. In this study, we show that ΔFosB, a long-lived transcription factor associated with chronic stress responses and drug-induced neuroplasticity, is upregulated in the medial prefrontal cortex and hippocampus of adult C57BL/6J mice isolated for two weeks postweaning. Additionally, a related transcription factor, FosB, is also increased in the medial prefrontal cortex in socially isolated females. These results show that short-term isolation during the critical post-weaning period has long-lasting and sex-dependent effects on gene expression in brain.

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Protective neuroendocrine effects of environmental enrichment and voluntary exercise against social isolation: evidence for mediation by limbic structures

Cited by 17 publications

References 66 publications

Voluntary wheel running protects against the increase in ethanol consumption induced by social stress in mice

Voluntary wheel running protects against the increase in ethanol consumption induced by social stress in mice

Differential impact of stress and environmental enrichment on corticolimbic circuits

Post-weaning social isolation increases ΔFosB/FosB protein expression in sex-specific patterns in the prelimbic/infralimbic cortex and hippocampus in mice

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