2005
DOI: 10.1016/j.ijpharm.2004.11.003
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Protective properties of melatonin-loaded nanoparticles against lipid peroxidation

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Cited by 77 publications
(52 citation statements)
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“…The antioxidant activity shown by Blank Np could be attributed to cationic chitosan coating as suggested earlier (Xie et al 2001). An another study have also reported enhancement in anti-lipid peroxidation activity of melatonin, a hydrophobic molecule upon its nanoencapsulation in different nanocarriers in the range of 8-51 % as compared to its free form (Schaffazick et al 2005). Similar observation was noted in anti-lipid peroxidation effect of CLN vs. CP in the current study.…”
Section: Thermal Characterization (Dsc)supporting
confidence: 89%
“…The antioxidant activity shown by Blank Np could be attributed to cationic chitosan coating as suggested earlier (Xie et al 2001). An another study have also reported enhancement in anti-lipid peroxidation activity of melatonin, a hydrophobic molecule upon its nanoencapsulation in different nanocarriers in the range of 8-51 % as compared to its free form (Schaffazick et al 2005). Similar observation was noted in anti-lipid peroxidation effect of CLN vs. CP in the current study.…”
Section: Thermal Characterization (Dsc)supporting
confidence: 89%
“…The assay of melatonin was performed by high-performance liquid chromatography using a previously validated methodology. 49 For this purpose, a PerkinElmer Series 200 chromatograph (PerkinElmer Inc., Waltham, MA, USA) was used, equipped with an ultravioletvisible detector; melatonin was quantified setting the detector at λ =229 nm. A guard-column and a column Nova-Pak C-18 (150×4.9 mm, 4 µm -Waters) were employed; a flow rate of 0.7 mL/min and an isocratic mobile phase of acetonitrile:water (55:45, v/v) were used.…”
Section: Drug Assaymentioning
confidence: 99%
“…The results of avidin-coated and uncoated nanoparticles were analyzed (Schaffazick et al, 2005). Avidin-coated nanospheres, in both analysis systems, were found to have a higher inhibition effect than uncoated nanospheres.…”
Section: Inhibition Of Plasma Lipid Peroxidationmentioning
confidence: 99%