Protective role of adiponectin against testicular impairment in high-fat diet/streptozotocin-induced type 2 diabetic mice

Choubey, Mayank; Ranjan, Amit; Bora, Puran S.; Krishna, Amitabh

doi:10.1016/j.biochi.2019.10.014

Cited by 45 publications

(31 citation statements)

References 52 publications

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“…Moreover, using NMR analysis, our laboratory found that DSF contains phytoandrogen contents called the terpenoid derivative substances Various testicular proteins have been reported to play important roles in steroidogenesis and spermatogenesis. The impaired alteration of testicular proteins was also demonstrated inT2DM animals (Choubey et al, 2020;Sampannang et al, 2019;Zhao et al, 2017). It is noted that tyrosine-phosphorylated (TyrPho) proteins are specifically localised within Sertoli cells and late spermatids (Arad-Dann et al, 1993;Ballester et al, 2004;Chaichun et al, 2017) in T1DM and T2DM animals is significantly decreased (Choubey et al, 2020;Liu et al, 2013;Nna et al, 2018;Sampannang et al, 2019) which is consistent with our recent report.…”

Section: Discussionsupporting

confidence: 91%

Dolichandrone serrulata flower extract ameliorates male reproductive damages in type 2 diabetic rats

et al. 2020

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Dolichandrone serrulata flower (DSF) has been believed to reduce blood glucose in hyperglycaemic persons with sub-fertility but its effect on improvement of male reproductive impairment has never been elucidated scientifically. This study attempted to investigate the hypoglycaemic effects of DSF on male reproductive damages in type 2 diabetes mellitus (T2DM) rats. Adult Sprague Dawley rats were divided into four groups (control, T2DM, DSF200 + T2DM and DSF600 + T2DM; n = 10/each). Control rats received low-fat diet for 14 days before saline injection while streptozocin (50 mg/kg BW) induced T2DM groups received high-fat diet and were orally administered with DSF (200 and 600 mg/kg BW) for 28 days. At the end, fasted blood glucose (FBG), malondialdehyde (MDA), testosterone, sperm quality, histology and protein expressions were examined. The result showed that DSF decreased high FBG and testicular MDA and increased testosterone levels of T2DM-treated rats. Lowsperm quality and histological malfunction were ameliorated in DSF-treated group. There was significant decrease in the expression of androgen receptor, heat-shock 70 and steroidogenic acute regulatory proteins of T2DM-treated rats. Our study demonstrated changes of six bands (116, 51, 45, 39, 35 and 29 kDas) of tyrosinephosphorylated proteins. In conclusion, DSF could reduce the FBGand ameliorate the reproductive damages in male T2DM rats.

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Section: Discussionsupporting

confidence: 91%

Dolichandrone serrulata flower extract ameliorates male reproductive damages in type 2 diabetic rats

et al. 2020

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“…To clarify the effect of cordycepin on diabetes‐induced testicular damage, we established a type 2 diabetic mice model induced by streptozotocin combined with high‐fat diet. Choubey M et al showed that adiponectin effectively improves testicular function in type 2 diabetic mice induced by, as well as streptozotocin combined with high‐fat diet (Choubey et al, 2020). A similar modelling method was used by Maremanda et al to show that a zinc‐deficient diet exacerbates testicular and epididymal damage in type 2 diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Cordycepin, a major bioactive component ofCordyceps militaris, ameliorates diabetes‐induced testicular damage through the Sirt1/Foxo3a pathway

Huang

Zhou

et al. 2021

Andrologia

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Diabetes‐induced male dysfunction is considered as a worldwide challenge, and testicular damage mainly caused by oxidative stress is its most common manifestation. Cordycepin, a natural antioxidant, has been used in the treatment of diabetic complications. However, the protective action and underlying mechanism of cordycepin on hyperglycaemia‐induced testicular damage are unclear. This study aimed to investigate the protective effects and molecular mechanisms of cordycepin against diabetes‐induced testicular damage. The type 2 diabetes model was established in C57BL/6 male mice via high‐fat diet for 4 weeks and injected intraperitoneally with 50 mg/kg/day streptozotocin for five consecutive days. Then mice were treated with cordycepin (10 and 20 mg/kg, respectively) for 8 weeks. At the end of experiment, biochemical indicators, microstructure of testicular tissue, sperm morphology, TUNEL staining and protein expressions were evaluated. In the present study, cordycepin alleviated the testicular damage, restored disruption of the blood‐testis barrier, and improved spermatogenic function via the antiapoptotic and antioxidant capacity. Mechanistically, cordycepin significantly enhanced SIRT1 expression and triggered the activity of Foxo3a, further to induce the expression of its downstream antioxidant enzymes, including Mn‐SOD and CAT. These findings indicated that cordycepin could improve hyperglycaemia‐induced testicular damage by regulating downstream antioxidant enzymes activity through the SIRT1/Foxo3a signalling pathway.

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“…In a study by Abdullah et al, it was reported that GSH improves diabetes-induced degraded testicular morphology and sperm quality, thanks to its antioxidant properties (25). Choubey et al reported that adiponectin reduced oxidative stress and had a protective role against testicular dysfunction in their study in high-fat diet+STZ-induced type-2 diabetic mice (26). In the same research, it stated that the treatment applied to mice decreased the increased lipid peroxidation caused by diabetes and elevated SOD activity.…”

Section: Discussionmentioning

confidence: 94%

Oxidative Stress Status in Testis of Type-2 Diabetic Rats Treated with Delta-9-Tetrahydrocannabinol

Tatar¹,

Pesen²,

Yazıcı³

et al. 2021

ejb

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Protective role of adiponectin against testicular impairment in high-fat diet/streptozotocin-induced type 2 diabetic mice

Cited by 45 publications

References 52 publications

Dolichandrone serrulata flower extract ameliorates male reproductive damages in type 2 diabetic rats

Dolichandrone serrulata flower extract ameliorates male reproductive damages in type 2 diabetic rats

Cordycepin, a major bioactive component ofCordyceps militaris, ameliorates diabetes‐induced testicular damage through the Sirt1/Foxo3a pathway

Oxidative Stress Status in Testis of Type-2 Diabetic Rats Treated with Delta-9-Tetrahydrocannabinol

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