Protective role of allicin (diallyl thiosulfinate) on cell surface glycoconjugate moieties in 7,12-dimethylbenz(a) anthracene-induced oral carcinogenesis

Dhanarasu, Sasikumar

doi:10.4314/tjpr.v16i8.7

Cited by 9 publications

(2 citation statements)

References 9 publications

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“…Table 1 summarizes the best reported phytoconstituents of garlic that have displayed significant anticancer potential. Allicin is the main sulfur containing active compound, and it produces a large number of allyl sulfur compounds that are oil-soluble and have anticancer properties ( Bat-Chen et al, 2010 ; Chen et al, 2016 ; Zou et al, 2016 ; Dhanarasu, 2017 ). Two different non-volatile organosulfur compounds, L-cysteine sulfoxides and γ-glutamyl-L-cysteine peptides (having γ-glutamyl-S-allyl-L-cysteine), are present in whole, intact garlic cloves.…”

Section: Major Active Constituents Of Allium Sativum ...mentioning

confidence: 99%

Updates on the anticancer potential of garlic organosulfur compounds and their nanoformulations: Plant therapeutics in cancer management

et al. 2023

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Garlic (Allium sativum L.) possesses numerous pharmacological potential, including antibacterial, antiarthritic, antithrombotic, anticancer, hypoglycemic, and hypolipidemic effects. The anti-cancer action of garlic is likely the best researched of the many advantageous pharmacological effects, and its use offers significant protection against the risk of developing cancer. A few active metabolites of garlic have been reported to be essential in the destruction of malignant cells due to their multi-targeted activities and lack of significant toxicity. The bioactive compounds in garlic having anticancer properties include diallyl trisulfide, allicin, allyl mercaptan diallyl disulfide, and diallyl sulphide. Different garlic-derived constituents and their nanoformulations have been tested for their effects against various cancers including skin, ovarian, prostate, gastric, breast, and lung, colorectal, liver, oral, and pancreatic cancer. The objective of this review is to summarize the antitumor activity and associated mechanisms of the organosulfur compounds of garlic in breast carcinoma. Breast cancer continues to have a significant impact on the total number of cancer deaths worldwide. Global measures are required to reduce its growing burden, particularly in developing nations where incidence is increasing quickly and fatality rates are still high. It has been demonstrated that garlic extract, its bioactive compounds, and their use in nanoformulations can prevent breast cancer in all of its stages, including initiation, promotion, and progression. Additionally, these bioactive compounds affect cell signaling for cell cycle arrest and survival along with lipid peroxidation, nitric oxide synthase activity, epidermal growth factor receptor, nuclear factor kappa B (NF-κB), and protein kinase C in breast carcinoma. Hence, this review deciphers the anticancer potential of garlic components and its nanoformulations against several breast cancer thereby projecting it as a potent drug candidate for efficient breast cancer management.

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Section: Major Active Constituents Of Allium Sativum ...mentioning

confidence: 99%

Updates on the anticancer potential of garlic organosulfur compounds and their nanoformulations: Plant therapeutics in cancer management

et al. 2023

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“…Dhanarasu 126 observed the effects of allicin in vivo with DMBA‐induced buccal tumors in Syrian golden hamsters. The experimental animals were administered with oral allicin at 20 mg/kg every other day for 23 days.…”

Section: Phytochemicals In Oral Cancer Researchmentioning

confidence: 99%

Bioactive phytocompounds for oral cancer prevention and treatment: A comprehensive and critical evaluation

Burcher

DeLiberto

Allen

et al. 2023

Medicinal Research Reviews

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The high incidence of oral cancer combined with excessive treatment cost underscores the need for novel oral cancer preventive and therapeutic options. The value of natural agents, including plant secondary metabolites (phytochemicals), in preventing carcinogenesis and representing expansive source of anticancer drugs have been established. While fragmentary research data are available on antioral cancer effects of phytochemicals, a comprehensive and critical evaluation of the potential of these agents for the prevention and intervention of human oral malignancies has not been conducted according to our knowledge. This study presents a complete and critical analysis of current preclinical and clinical results on the prevention and treatment of oral cancer using phytochemicals. Our in‐depth analysis highlights anticancer effects of various phytochemicals, such as phenolics, terpenoids, alkaloids, and sulfur‐containing compounds, against numerous oral cancer cells and/or in vivo oral cancer models by antiproliferative, proapoptotic, cell cycle‐regulatory, antiinvasive, antiangiogenic, and antimetastatic effects. Bioactive phytochemicals exert their antineoplastic effects by modulating various signaling pathways, specifically involving the epidermal growth factor receptor, cytokine receptors, toll‐like receptors, and tumor necrosis factor receptor and consequently alter the expression of downstream genes and proteins. Interestingly, phytochemicals demonstrate encouraging effects in clinical trials, such as reduction of oral lesion size, cell growth, pain score, and development of new lesions. While most phytochemicals displayed minimal toxicity, concerns with bioavailability may limit their clinical application. Future directions for research include more in‐depth mechanistic in vivo studies, administration of phytochemicals using novel formulations, investigation of phytocompounds as adjuvants to conventional treatment, and randomized clinical trials.

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Revitalizing allicin for cancer therapy: advances in formulation strategies to enhance bioavailability, stability, and clinical efficacy

Bala,

Madaan,

Chauhan

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Protective role of allicin (diallyl thiosulfinate) on cell surface glycoconjugate moieties in 7,12-dimethylbenz(a) anthracene-induced oral carcinogenesis

Abstract: Purpose: To evaluate the protective and restoring effects of allicin in 7,12-dimethylbenz(a)

Cited by 9 publications

References 9 publications

Updates on the anticancer potential of garlic organosulfur compounds and their nanoformulations: Plant therapeutics in cancer management

Updates on the anticancer potential of garlic organosulfur compounds and their nanoformulations: Plant therapeutics in cancer management

Bioactive phytocompounds for oral cancer prevention and treatment: A comprehensive and critical evaluation

Revitalizing allicin for cancer therapy: advances in formulation strategies to enhance bioavailability, stability, and clinical efficacy

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