Protective Role of .ALPHA.-Tocopherol Acetate against Thioacetamide-Induced Mitochondrial Dysfunction.

Abstract

SummaryIt was reported earlier that administration of an acute dose of thioacetamide to rats produced changes in the rate of respiration, phosphate to oxygen ratio, and respiratory control ratio when either glutamate + malate or succinate were used as substrates (Padma and Setty, J Clin. Biochem. Nutr., 22,[113][114][115][116][117][118][119][120][121][122][123]. A significant decrease in the activities of electron transport chain enzymes was also observed. In the present study we report that administration of vitamin E prior to thioacetamide administration provided significant protection against the mitochondrial dysfunctions induced by thioacetamide. We speculate that the protective effect of vitamin E may be due to the ability of this vitamin to suppress elevated lipid peroxide levels in rats.

Medicinal Plants and Cancer Chemoprevention

“…These processes are suggested to defend the tissue against peroxidation reaction and thus protects it against cell damage [66]. Oral consumption of leaves of C. asiatica have been shown to provide protection against oxidative damage [68]. Chemical structure of asiaticoside, a major component of C. asiatica is shown below.…”