Protective role of black seed oil in doxorubicin-induced cardiac toxicity in children with acute lymphoblastic leukemia

Hagag, Adel A; Badraia, Ibrahim M; El-Shehaby, Walid Ahmed; Mabrouk, Maaly M.

doi:10.1177/1078155219897294

Cited by 8 publications

(16 citation statements)

References 25 publications

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Section: Study Characteristicsmentioning

confidence: 99%

“…Four human studies were conducted in Egypt [in 2021 (91) and 2020 (92)], Italy [in 1994 (93)] and the USA [in 1978 (94)]. Three studies (91)(92)(93) recruited pediatric patients diagnosed with acute lymphoblastic leukemia (ALL) aged 1 to 16 years and one (94) recruited adults with bronchogenic carcinoma. Two studies (91,92) were RCTs using DOX as the chemotherapy agent, and the other two studies (93,94) were non-randomized controlled trials using anthracyclines.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Three studies (91)(92)(93) recruited pediatric patients diagnosed with acute lymphoblastic leukemia (ALL) aged 1 to 16 years and one (94) recruited adults with bronchogenic carcinoma. Two studies (91,92) were RCTs using DOX as the chemotherapy agent, and the other two studies (93,94) were non-randomized controlled trials using anthracyclines. The covered dietary nutrients contained PUFA [n = 2, derived from omega 3 fatty acids (91) and black seed oil (92)] and CoQ10 (n = 2) (93,94).…”

Section: Study Characteristicsmentioning

confidence: 99%

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Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models

Zhang

Yang²,

Li³

et al. 2022

Front. Cardiovasc. Med.

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IntroductionChemotherapy has significantly improved cancer survival rates at the cost of irreversible and frequent cardiovascular toxicity. As the main dose-dependent adverse effect, cardiotoxic effects not only limit the usage of chemotherapeutic agents, but also cause the high risk of severe poor prognoses for cancer survivors. Therefore, it is of great significance to seek more effective cardioprotective strategies. Some nutrients have been reported to diminish cardiac oxidative damage associated with chemotherapy. However, the currently available evidence is unclear, which requires a rigorous summary. As such, we conducted a systematic review of all available evidence and demonstrated whether nutrients derived from food could prevent cardiotoxicity caused by chemotherapy.MethodsWe searched Medline (via PubMed), Embase and the Cochrane Library from inception to Nov 9, 2021 to identify studies reporting dietary nutrients against cancer chemotherapy-related cardiotoxicity. We performed descriptive summaries on the included studies, and used forest plots to demonstrate the effects of various dietary nutrients.ResultsFifty-seven eligible studies were identified, involving 53 animal studies carried on rats or mice and four human studies in cancer patients. Seven types of dietary nutrients were recognized including polyphenols (mainly extracted from grapes, grape seeds, and tea), allicin (mainly extracted form garlic), lycopene (mainly extracted from tomatoes), polyunsaturated fatty acids, amino acids (mainly referring to glutamine), coenzyme Q10, and trace elements (mainly referring to zinc and selenium). Dietary nutrients ameliorated left ventricular dysfunctions and myocardial oxidative stress at varying degrees, which were caused by chemotherapy. The overall risk of bias of included studies was at moderate to high risk.ConclusionThe results indicated that dietary nutrients might be a potential strategy to protect cardiovascular system exposed to the chemotherapeutic agents, but more human studies are urged in this field.Systematic Review Registration:https://inplasy.com/inplasy-2022-3-0015/.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models

Zhang

Yang²,

Li³

et al. 2022

Front. Cardiovasc. Med.

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“…As the primary component of the heart structure, cardiomyocytes are the basis to maintain normal physiological functions of the heart. The fate of cardiomyocytes from DOX treatment has attracted significant attention from the bench to the clinic ( Hagag et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Higenamine Attenuates Doxorubicin-Induced Cardiac Remodeling and Myocyte Apoptosis by Suppressing AMPK Activation

Jin

Chai

et al. 2022

Front. Cell Dev. Biol.

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Background: As an effective antitumor drug, doxorubicin (DOX) is primarily used to treat solid tumors and hematologic malignancies. However, increasing evidence has emerged indicating its cardiotoxicity, and few solutions have been proposed to counter this side effect. Higenamine (HG) is a natural compound widely found in many Chinese herbs and also serves as a component in many healthcare products. Several studies have demonstrated its cardioprotective effect in different models, but little is known about the underlying influences of HG against myocardial damage from DOX-induced chronic cardiotoxicity.Methods and Results: C57BL/6 mice and neonatal rat ventricular cardiomyocytes (NRVMs) were used to evaluate the cardioprotective effect of HG against DOX-induced myocardial damage. In mice, DOX (intraperitoneally injected 5 mg/kg every 3 days for 4 weeks) significantly increased cardiomyocyte apoptosis, cardiac atrophy, and cardiac dysfunction, which were significantly attenuated by HG (intragastrically administered with 10 mg/kg every day for 4 weeks). In NRVMs, DOX (3 μM for 24 h) significantly increased cell apoptosis and the level of reactive oxygen species while reducing the level of superoxide dismutase and mitochondrial membrane potential. Remarkably, HG can reverse these pathological changes caused by DOX. Interestingly, the protective effect of HG on DOX-induced cardiotoxicity was independent of the activation of the beta-2 adrenergic receptor (β2-AR), known for mediating the effect of HG on antagonizing ischemia/reperfusion-induced cardiac apoptosis. Furthermore, HG attenuated the abnormal activation of phosphorylated adenosine-activated protein kinase (AMPK). Consistently, AMPK agonists (AICAR) can eliminate these pharmacological actions of HG.Conclusion: Collectively, our results suggested that HG alleviated DOX-induced chronic myocardial injury by suppressing AMPK activation and ROS production.

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“…It restores the multiple organ toxicity caused by cyclophosphamide, cisplatin-induced nephrotoxicity, doxorubicin induced cardio and nephrotoxicity, paracetamol-induced hepatotoxicity, to name a few. These alterations were restored by N. sativa [6][7][8][9]. Mechanisms of reduction of toxicity by N. sativa involve anti-inflammatory, antioxidant, restore of antioxidant defence systems, free radical scavenging, improvement in the disturbed levels of biochemical markers, regulatory effects on genes expression and inhibition of apoptosis, and various signalling pathways.…”

Section: Introductionmentioning

confidence: 99%

Biochemical evaluation of Nigella sativa L. seeds on fluconazole toxicity in Wistar rats

Anwar

Nadeem

Alghamdi

et al. 2020

Journal of Taibah University for Science

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Nigella sativa L. seed commonly known as black seed, extensively used as a folk medicine in Middle East and Asian subcontinent. Traditionally it is used as an adjunct therapy along with modern medicine to counter the adverse effects. Pure thymoquinone or isolated compounds are not free from adverse effects. The present study was undertaken to evaluate N. sativa seeds powder impact on the fluconazole (FLZ) induced toxicities in the liver and kidneys. Male Wistar rats were acclimatized, divided into four groups each group with six animals. Experimental animals were subjected to an FLZ dose of 50 mg per kg of body mass. The toxic effects of FLZ treatment were manifested and animals were given 1000 mg of N. sativa seeds powder per kg of body weight to observe any retrieval. Dissected animals were evaluated for biochemical and histopathology alterations. Based on findings, it can be concluded that N. sativa seeds powder restored various altered biochemical parameters induced by fluconazole and can be used along with fluconazole in the treatment of fungal infections.

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Protective role of black seed oil in doxorubicin-induced cardiac toxicity in children with acute lymphoblastic leukemia

Cited by 8 publications

References 25 publications

Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models

Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models

Higenamine Attenuates Doxorubicin-Induced Cardiac Remodeling and Myocyte Apoptosis by Suppressing AMPK Activation

Biochemical evaluation of Nigella sativa L. seeds on fluconazole toxicity in Wistar rats

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