Protective role of carbon dioxide (CO2) in generation of reactive oxygen species

Abstract

The results testify to the fact that CO2 is a powerful inhibitor of reactive oxygen species (ROS) generation by cells (blood phagocytes and alveolar macrophages of 96 people and cells of inner organs and tissue phagocytes (of liver, brain, myocardium, lungs, kidneys, stomach, and skeleton muscles), as well as by mitochondria of the liver of 186 white mice and human tissues. Generation of ROS was determined using various methods with CO2 directly acting on the cells and bioptates and indirectly on the organism as a whole. CO2 in the concentration of 5.1% (P = 37.5 mmHg), 8.2% (P = 60.0 mmHg), and 20% (P = 146.0 mmHg) in a mixture with air (total pressure = 730 mmHg) inhibits the basal ROS generation by phagocytes on the average by 3.52, 5.69, and 10.03 times, respectively (p < 0.05), and the stimulated by corpuscular particles: (a) zymosan by 3.24, 4.43, and 7.95 times; (b)SiO2: by 2.99, 3.24, and 5.76 times (p < 0.05). This is confirmed by the feet that CO2, along with inhibiting the O2 (-) generation by cells of the various organs, including the liver, as a rule, by 2.19-4.7 times, p < 0.01 or <0.001 induces simultaneously a decrease in the O2 (-) generation by mitochondria isolated from the liver (by 1.91-3.2 times, p < 0.001). The mechanism of CO2 influence is realized, in part, by inhibition of NADPH-oxidase activity. Taken into consideration proven role of CO2 in different pathophysiological conditions, (such as endoarteritis, bronchial asthma, and infectious diseases), present findings may be of clinical interest in terms of potential implementation of CO2 donors as adjuvant therapeutics in these diseases.

Carbon dioxide water-bath treatment augments peripheral blood flow through the development of angiogenesis

“…It is pointed out that Dogliotti et al (2011) have shown a depression of free radical release and elevation of the total antioxidant status upon immersion of lower legs of patients with peripheral occlusive disease in CO 2 -enriched water. In fact, CO 2 has been found to be a potent inhibitor for the generation of reactive oxygen species by different types of cells (Bolevich et al 2016).…”

Angiotensin-converting Enzyme Inhibition Improves the Effectiveness of Transcutaneous Carbon Dioxide Treatment

“…After the initial decrease of ADMA concentrations, we observed an increase within 24 hours after the CO 2 treatment, which may be due to a rebound effect explained by the subsiding of the vasodilator effect. In a recent study, Bolevich et al have proved that CO 2 is "a universal inhibitor of oxidative stress" (18). Reduced oxidative stress results in an increased efficiency of DDAH leading to decreased ADMA levels (16).…”

Chemical Interactions at the Interface of Plant Root Hair Cells and Intracellular Bacteria

“…Elevated carbon dioxide gas was used to inhibit formation of superoxide by NADPH oxidases [ 34 ]. Here, seeds of Poa annua , Poa reptans , Festuca arundinacea , Oryza sativa , Tritichum aestivum and Solanum lycopersicum were planted into potting mix or agarose in magenta boxes.…”