Protective role of curcumin against nicotine-induced genotoxicity on rat liver under restricted dietary protein

Bandyopadhyaya, Gargi; Sinha, Surajit; Chattopadhyay, Brajadulal; Chakraborty, Anindita

doi:10.1016/j.ejphar.2008.04.023

Cited by 39 publications

(29 citation statements)

References 47 publications

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“…The apoptotic changes may result partially from the deleterious toxic effects of nicotine through increased production of reactive oxygen species (ROS) [22,23]. The free radicals produced would lead to cellular injury.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Prenatal Exposure to Nicotine versus Thiocyanate on Pituitary-Testicular Axis of Juvenile Albino Rats: A Comparative Histological and Electron Microscopic Study

Ahmed¹,

Sg²

2016

J Cytol Histol

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Cigarette smoking prevalence is still increasing in the developing world especially among men mainly in central Asia, east Europe and Africa. Furthermore, maternal cigarette smoking during pregnancy has multiple deleterious effects on the offspring, which may persist into adulthood. The present work aims at clarifying whether the prenatal exposure to either nicotine or thiocyanate could be the responsible factor in induction of the possible effect of smoking on spermatogenesis and the cytoarchitecture of the testis and hence influencing the male fertility later on. Twenty pregnant rats were randomly divided into four groups from gestational day 4. Groups Ia and b served as control. Group II animals were injected with nicotine (6 mg/kg/day) subcutaneously as a single dose. Group III Animals were treated with oral potassium thiocyanate (25 mg/rat/day) as a single dose through gastric gavages. Five male litters from each group (one/each pregnant rat) were sacrificed at the age of 1 month. Pituitary and testicular tissue samples were subjected to histological and electron microscopic study. The counts of different cells of seminiferous tubules were statistically analyzed for significance. Results revealed apoptotic changes at the subcellular level of the pituitary gonadotrophs and different spermatogenic and Sertoli cells of the testis. The number of Sertoli and different spermatogenic cells-rather than spermatogonia-showed a very highly significant decrease in the nicotine treated group in comparison to the control. The dense cells revealed a very highly significant increase in the nicotine treated group. In conclusion, the results of the present study were more consistent with a suggested dual effect of nicotine on the pituitary-testicular axis rather than a purely direct effect on the testis. On the other hand, thiocyanate induced subcellular effect on the testicular histology with minimal affection of gonadotrophs.

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Section: Discussionmentioning

confidence: 99%

The Effect of Prenatal Exposure to Nicotine versus Thiocyanate on Pituitary-Testicular Axis of Juvenile Albino Rats: A Comparative Histological and Electron Microscopic Study

Ahmed¹,

Sg²

2016

J Cytol Histol

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“…79e81 Curcumin (given orally at 80 mg/kg body weight) also reduced nicotine-induced DNA damage in liver tissue of female Wister rats by 24% and down-regulated nicotine-induced survival signals including MAPKs, Akt, NF-kB and AP-1 in H1299 lung cancer cells. 82,83 In another study, curcumin (20 mmol/L) has been found to block nicotine-induced Akt/mTOR signaling in head and neck squamous cell carcinoma cells; it also inhibits NNK-induced NF-kB activation and COX-2 expression in oral cancer cells. 84,85 Although curcumin possess various biological properties, its bioavailability for humans is poor because of poor absorption, rapid metabolism, and rapid systemic elimination.…”

Section: Chemopreventive Mechanisms Of Other Polyphenolic Compoundsmentioning

confidence: 98%

Mechanism for Possible Chemopreventive Effects of Natural Dietary Compounds on Smoking-induced Tumorigenesis

Lai

Pan

2011

Journal of Experimental & Clinical Medicine

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“…The excess production of ROS is the major cause of infertility by damaging the DNA, genetic components and activities of enzymes [13]. ROS can be useful or harmful depending on the site as well as their level of production [14].…”

Section: Production Of Ros and Male Infertilitymentioning

confidence: 99%

Effects of dietary vitamin E on male reproductive system

Zubair¹

2017

APJR

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Protective role of curcumin against nicotine-induced genotoxicity on rat liver under restricted dietary protein

Cited by 39 publications

References 47 publications

The Effect of Prenatal Exposure to Nicotine versus Thiocyanate on Pituitary-Testicular Axis of Juvenile Albino Rats: A Comparative Histological and Electron Microscopic Study

The Effect of Prenatal Exposure to Nicotine versus Thiocyanate on Pituitary-Testicular Axis of Juvenile Albino Rats: A Comparative Histological and Electron Microscopic Study

Mechanism for Possible Chemopreventive Effects of Natural Dietary Compounds on Smoking-induced Tumorigenesis

Effects of dietary vitamin E on male reproductive system

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