Protective Role of Dietary Factors in Carcinogenesis of Digestive Organs

Mori, Hideki; Tanaka, Takuji; Sugie, Shigeyuki; Yoshimi, Naoki; Kawamori, Toshihiko; Hirose, Yoshio; Osawa, Toshihiko

doi:10.1007/978-4-431-67017-9_18

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…In fact, the chemopreventive effect of costunolide on large bowel carcinogenesis is also demonstrated in our laboratory [27]. Recently, we found that apoptosis occurs very fast in the mucosal epithelium for the target sites on AOM-induced colorectal carcinogenesis [39]; in vivo pretreatment with disulfiram, an inhibitor of oxidation in the metabolism of AOM, strongly suppressed AOM-induced apoptosis in the colons of rats [3]. Such biological events seen in the large bowel may be regarded as useful biomarkers for screening chemopreventive agents.…”

Section: Short-term Assays For Screening Chemopreventive Agents and Pmentioning

confidence: 85%

“…They included antioxidative properties or effects on cell proliferation [2]. Combining such properties makes possible the establishment of short-term assays for screening chemopreventive agents [3]. This report shows chemopreventive effects of naturally occurring chemicals, including phenolic compounds, organosulfur compounds and carotenoids, and some related synthetic chemicals, on oral, liver, or large-bowel carcinogenesis.…”

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confidence: 98%

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Chemoprevention by naturally occurring and synthetic agents in oral, liver, and large bowel carcinogenesis

et al. 1997

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A number of naturally occurring compounds and several related synthetic agents were confirmed to exert chemopreventive properties against carcinogenesis in the digestive organs. Phenolic compounds, widely distributed as plant constituents, possess chemopreventive activities in tongue, liver, and large bowel of rodents. Of them, a simple phenolic protocatechuic acid seems to be a promising compound. Organosulfur compounds contained in the cruciferous vegetables and known to activate detoxifying enzymes are regarded as a candidate group for cancer preventive agents. We proved a strong protective effect of S-methylmethanethiosulfonate, a constituent in these vegetables, on azoxymethane (AOM)-induced large bowel carcinogenesis. Some oxygenated carotenoids (xanthophylls) are reported to have antitumor effects. Naturally occurring xanthophylls astaxanthin and canthaxanthin have considerable preventive activities on 4-nitroquinoline-1-oxide (4-NQO)-induced tongue carcinogenesis and AOMinduced large bowel carcinogenesis. A novel synthesized retinoidal butenolide, KYN-54, which suppresses large bowel as well as tongue carcinogenesis, could be a useful agent for prevention of digestive organ cancers. Some trace elements are known to have anticarcinogenic effects. Magnesium hydroxide, a protective agent in colorectal carcinogenesis, inhibits c-myc expression and ornithine decarboxylase activity in the mucosal epithelium of the intestine. Our results show that many agents with preventive effects in tongue, liver, and large bowel control carcinogen-induced hyperproliferation of cells in these organs. Carcinogens used to induce large bowel cancers also induce apoptosis in the target sites. Telomerase activity is increased in the tissues of preneoplastic as well as neoplastic lesions in experimental models such as dimethylbenz [a]anthracene-induced oral carcinogenesis in hamsters. These could be useful biomarkers in studies for cancer chemoprevention.

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Section: Short-term Assays For Screening Chemopreventive Agents and Pmentioning

confidence: 85%

mentioning

confidence: 98%

Chemoprevention by naturally occurring and synthetic agents in oral, liver, and large bowel carcinogenesis

et al. 1997

Self Cite

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show abstract

“…They in-cluded antioxidative properties or effects on cell proliferation [2]. Combining such properties makes possible the establishment of short-term assays for screening chemopreventive agents [3]. This report shows chemopreventive effects of naturally occurring chemicals, including phenolic compounds, organosulfur compounds and carotenoids, and some related synthetic chemicals, on oral, liver, or large-bowel carcinogenesis.…”

mentioning

confidence: 99%

Chemoprevention by naturally occurring and synthetic agents in oral, liver, and large bowel carcinogenesis

Mori¹,

Tanaka²,

Sugie³

et al. 1997

J. Cell. Biochem.

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A number of naturally occurring compounds and several related synthetic agents were confirmed to exert chemopreventive properties against carcinogenesis in the digestive organs. Phenolic compounds, widely distributed as plant constituents, possess chemopreventive activities in tongue, liver, and large bowel of rodents. Of them, a simple phenolic protocatechuic acid seems to be a promising compound. Organosulfur compounds contained in the cruciferous vegetables and known to activate detoxifying enzymes are regarded as a candidate group for cancer preventive agents. We proved a strong protective effect of S-methylmethanethiosulfonate, a constituent in these vegetables, on azoxymethane (AOM)-induced large bowel carcinogenesis. Some oxygenated carotenoids (xanthophylls) are reported to have antitumor effects. Naturally occurring xanthophylls astaxanthin and canthaxanthin have considerable preventive activities on 4-nitroquinoline-1-oxide (4-NQO)-induced tongue carcinogenesis and AOMinduced large bowel carcinogenesis. A novel synthesized retinoidal butenolide, KYN-54, which suppresses large bowel as well as tongue carcinogenesis, could be a useful agent for prevention of digestive organ cancers. Some trace elements are known to have anticarcinogenic effects. Magnesium hydroxide, a protective agent in colorectal carcinogenesis, inhibits c-myc expression and ornithine decarboxylase activity in the mucosal epithelium of the intestine. Our results show that many agents with preventive effects in tongue, liver, and large bowel control carcinogen-induced hyperproliferation of cells in these organs. Carcinogens used to induce large bowel cancers also induce apoptosis in the target sites. Telomerase activity is increased in the tissues of preneoplastic as well as neoplastic lesions in experimental models such as dimethylbenz[a]anthracene-induced oral carcinogenesis in hamsters. These could be useful biomarkers in studies for cancer chemoprevention.

show abstract