Protective role of hispolon and its derivatives against apoptosis in cortical neurons induced by electromagnetic radiation from 4G mobile phone

Saka, Vara Prasad; Chitra, V.; Narayanasamy, Damodharan

doi:10.1002/jbt.23351

Cited by 5 publications

(3 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using the screening criterion of OB ≥ 5% and DL ≥ 0.14%, a total of 79 metabolites were identified as the key active metabolites. Two well-known styrylpyrone-class compounds, namely, hispolon and hispidin, have been widely isolated and verified to possess significant biological properties in Sanghuangporus species ( Gonindard et al, 1997 ; Anouar et al, 2014 ; Wu et al, 2014 ; Benarous et al, 2021 ; Liao et al, 2021 ; Palkina et al, 2021 ; Saka et al, 2023 ). However, these two compounds have not been included in the TCMSP database.…”

Section: Resultsmentioning

confidence: 99%

Widely targeted metabolomics analysis of Sanghuangporus vaninii mycelia and fruiting bodies at different harvest stages

Qi,

Guo,

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

Sanghuangprous vaninii is a medicinal macrofungus cultivated extensively in China. Both the mycelia and fruiting bodies of S. vaninii have remarkable therapeutic properties, but it remains unclear whether the mycelia may serve as a substitute for the fruiting bodies. Furthermore, S. vaninii is a perennial fungus with therapeutic components that vary significantly depending on the growing year of the fruiting bodies. Hence, it is critical to select an appropriate harvest stage for S. vaninii fruiting bodies for a specific purpose. With the aid of Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), metabolomics based on ultra-high performance liquid chromatography coupled to triple quadrupole mass spectrometry (UHPLC-QQQ-MS) was used to preliminarily determine 81 key active metabolites and 157 active pharmaceutical metabolites in S. vaninii responsible for resistance to the six major diseases. To evaluate the substitutability of the mycelia and fruiting bodies of S. vaninii and to select an appropriate harvest stage for the fruiting bodies of S. vaninii, we analyzed the metabolite differences, especially active metabolite differences, among the mycelia and fruiting bodies during three different harvest stages (1-year-old, 2-year-old, and 3-year-old). Moreover, we also determined the most prominent and crucial metabolites in each sample of S. vaninii. These results suggested that the mycelia show promise as a substitute for the fruiting bodies of S. vaninii and that extending the growth year does not necessarily lead to higher accumulation levels of active metabolites in the S. vaninii fruiting bodies. This study provided a theoretical basis for developing and using S. vaninii.

show abstract

Section: Resultsmentioning

confidence: 99%

Widely targeted metabolomics analysis of Sanghuangporus vaninii mycelia and fruiting bodies at different harvest stages

Qi,

Guo,

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…It is distributed in China, Korea, Japan, Germany, Russia, Canada and other countries. Recent international medical studies reported that its pharmacological activities include anti-tumor, anti-oxidation, anti-inflammatory, liver protection, bacteriostasis, anti-virus, hypolipidemic and immune enhancement (Awadh et al, 2003;Benarous et al, 2015;Gründemann et al, 2016;Angelini et al, 2019;Liu et al, 2019;Yang et al, 2020;Li and Bao, 2022a;Zhang et al, 2022a;Machado-Carvalho et al, 2023;Saka et al, 2023;Tang et al, 2023). I. hispidus has an excellent development space as medical and functional food in future.…”

Section: Metabonomic Analysis Of Different Color Strainsmentioning

confidence: 99%

Genetics, genomics, and breeding of edible mushrooms in Asia

2024

Frontiers Research Topics

View full text Add to dashboard Cite

Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

show abstract

“…It is distributed in China, Korea, Japan, Germany, Russia, Canada and other countries. Recent international medical studies reported that its pharmacological activities include anti-tumor, anti-oxidation, anti-inflammatory, liver protection, bacteriostasis, anti-virus, hypolipidemic and immune enhancement ( Awadh et al, 2003 ; Benarous et al, 2015 ; Gründemann et al, 2016 ; Angelini et al, 2019 ; Li et al, 2019 ; Liu et al, 2019 ; Yang et al, 2019 ; Yang et al, 2020 ; Li and Bao, 2022a ; Zhang et al, 2022a ; Yang et al, 2022 ; Machado-Carvalho et al, 2023 ; Saka et al, 2023 ; Tang et al, 2023 ). I. hispidus has an excellent development space as medical and functional food in future.…”

Section: Introductionmentioning

confidence: 99%

Genomic comparison between two Inonotus hispidus strains isolated from growing in different tree species

Wang

Bao

2023

Front. Genet.

View full text Add to dashboard Cite

Inonotus hispidus mainly growing in broad-leaved trees, including Morus alba, Fraxinus mandshurica, and Ulmus macrocarpa etc. The fruiting body of I. hispidus growing in M. alba (hereafter as MA) is used as a traditional Chinese medicine “Sanghuang”. However, differences between the genetic material basis of I. hispidus growing in other tree species have not been reported. Therefore, in this paper, the genomic comparison between MA and I. hispidus growing in F. mandshurica (hereafter as FM) were studied. The whole genome of MA monokaryon was sequenced by Illumina combined with Pac Bio platform. Next, genome assembly, genome component prediction and genome functional annotation were performed. Comparative genomics analysis was performed between FM monokaryon and MA monokaryon, using MA as the reference. The results showed that, MA had 24 contigs with a N50 length of 2.6 Mb. Specifically, 5,342, 6,564, 1,595, 383 and 123 genes were annotated from GO, KEGG, KOG, CAZymes and CYP450, respectively. Moreover, comparative genomics showed that, the coding genes and total number of genes annotated in different databases of FM were higher than that of MA. This study provides a foundation for the medicinal application of FM as MA from the perspective of genetic composition.

show abstract

Protective role of hispolon and its derivatives against apoptosis in cortical neurons induced by electromagnetic radiation from 4G mobile phone

Cited by 5 publications

References 80 publications

Widely targeted metabolomics analysis of Sanghuangporus vaninii mycelia and fruiting bodies at different harvest stages

Widely targeted metabolomics analysis of Sanghuangporus vaninii mycelia and fruiting bodies at different harvest stages

Genetics, genomics, and breeding of edible mushrooms in Asia

Genomic comparison between two Inonotus hispidus strains isolated from growing in different tree species

Contact Info

Product

Resources

About