2012
DOI: 10.2131/jts.37.363
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Protective role of intestinal bacterial metabolism against baicalin-induced toxicity in HepG2 cell cultures

Abstract: -Baicalin, a glycoside present in Scutellaria baicalensis Georgi, is metabolized to its aglycone, baicalein, in intestine. In the present study, possible role of metabolism of baicalin by intestinal bacteria to baicalein in baicalin-induced toxicity was investigated in HepG2 cell cultures. As an intestinal bacterial metabolic system for baicalin, human fecal preparation containing intestinal microflora (fecalase) was employed. Initially, when cytotoxic effects of baicalin and baicalein were compared, baicalin … Show more

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Cited by 20 publications
(17 citation statements)
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“…To determine whether or not there is a cytotoxic effect on developing embryos following the application of Baicalin 31 , HH0 chick embryos were first incubated with 3, 6, 12 and 24 μM Baicalin for 26, 39 and 48 h in EC culture (Fig. 1a ), respectively.…”
Section: Resultsmentioning
confidence: 99%
“…To determine whether or not there is a cytotoxic effect on developing embryos following the application of Baicalin 31 , HH0 chick embryos were first incubated with 3, 6, 12 and 24 μM Baicalin for 26, 39 and 48 h in EC culture (Fig. 1a ), respectively.…”
Section: Resultsmentioning
confidence: 99%
“…Khanal et al . [37] investigated cytotoxicity and apoptotic effects of baicalin and baicalein in HepG2 cells. The results indicated that baicalin was more cytotoxic than baicalein in HepG2 cells, and the number of apoptotic cells and DNA fragmentation by baicalin were also much higher than baicalein.…”
Section: Role Of Intestinal Microbiota In Efficacy and Toxicity Ofmentioning
confidence: 99%
“…The results indicated that baicalin was more cytotoxic than baicalein in HepG2 cells, and the number of apoptotic cells and DNA fragmentation by baicalin were also much higher than baicalein. When baicalin was incubated with human fecal suspension (fecalase), however, the cytotoxic effect in HepG2 cells was abolished in a concentration-dependent manner, and apoptotic cell death was also significantly decreased [37]. These results clearly indicated that metabolism of baicalin by human fecalase to baicalein might have a protective effect against baicalin-induced toxicity in HepG2 cells [37].…”
Section: Role Of Intestinal Microbiota In Efficacy and Toxicity Ofmentioning
confidence: 99%
“…On the other hand, it was recently discovered that the toxicological actions of many xenobiotics present in foods or medicinal plants, can be metabolically modulated by human intestinal microflora. These include arbutin, baicalin, geniposide and butyl paraben (Figure 1), [30,31].…”
Section: Staphylococcusmentioning
confidence: 99%