Protective role of Nigerian honey on sperm indices and testis in sucrose-fed rat

Oyelowo, Oluwakemi; Adekunbi, Daniel; Dada, Kayode

doi:10.1530/endoabs.34.p315

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…Another study on applied to rats showed that persistent consumption of Nigerian honey (i.e 5 ml/kg and 7.5 ml/kg body weight) had a negative impact on sperm parameters and fertility potential of male Wistar rats (Dare, Igbigbi, & Avwioro, 2013). Oyelowo et al (2014) also studied the protective potential of Nigerian honey on sperm indices and testis in sucrose-fed rats. They found that the high sucrose diet had adverse impacts on male reproductive function Composition, nutritional, antioxidant of honey while honey feeding showed a protective impact on reproductive dysfunction.…”

Section: Anti-inflammatorymentioning

confidence: 99%

Chemical Composition, Nutritional Functions, and Antioxidant Activities of Honeys in Africa

Tahir

Mariod

Mahunu

et al. 2019

Journal of Apicultural Science

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Honey production in Africa is considered an integral part of folk medicine and provides an opportunity for poor rural communities to increase their economic sustainability. In this review, we provide and discuss the data available on the positive nutritional value and health properties of honey harvested from Africa. Besides sugar, honey contains protein and amino acids, with proline which is about 50% of the total amino acids, vitamins, enzymes, some minerals (Na, K, Mg, Ca, Zn, Cu, Mn, Fe, P, S), trace elements (Mn, Ni, Li, F, I, Cl, Sr, Co) and polyphenol compounds. The paper reviewed studies on the use of African honey with anti-inflammatory, antioxidant, antibacterial, antifungal, anti-breast cancer, antidiabetic and antimycotic properties and also its positive effects on infertility (asthenozoospermia), febrile neutropenia and diabetic foot ulcers.

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Section: Anti-inflammatorymentioning

confidence: 99%

Chemical Composition, Nutritional Functions, and Antioxidant Activities of Honeys in Africa

Tahir

Mariod

Mahunu

et al. 2019

Journal of Apicultural Science

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Trihoney ameliorates hypercholesterolemia-induced epididymal histopathological changes in male rabbits

Mohamed

Ibrahim

Alfarisi

et al. 2020

APJMBB

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Hypercholesterolemia has been linked to weight change and histopathological alteration of male reproductive organs. The epididymis was suggested to be an early target of lipid-related infertility and can be dramatically affected by excess intake of a high cholesterol diet. On the other hand, the interest has been increased towards the use of honey as a prophylactic and therapeutic agent for various diseases. Therefore, the purpose of this study is to investigate the effects of Trihoney (a mixture of Trigona, Mellifera and Tualang) on epididymal weight change and histopathological alterations in hypercholesterolemic male rabbits and compare its effects with atorvastatin. Forty-eight mature male New Zealand white rabbits were divided into 6 groups. Two groups received standard rabbit pellet with 0 and 0.6 g/kg/day of Trihoney respectively while the other four groups received 1% cholesterol diet with 0, 0.3, 0.6 g/kg/day of Trihoney, and 2 mg/kg/day of atorvastatin. After 12 weeks, the rabbits were sacrificed and the epididymides were harvested for evaluation of weight and histopathological changes. Administration of 1% cholesterol diet either alone or in combination with atorvastatin caused a significant reduction in the epididymal weight and epididymal atrophy. Supplementation of Trihoney particularly at the dose of 0.6 g/kg/day improved epididymal weight, regained the normal architecture of the epididymal histology and increased the number of mature sperm inside the tubules of the epididymis. Based on these results, Trihoney exhibited its potential health benefit as a protective agent against epididymal weight reduction and histopathological alterations in hypercholesterolemic rabbits.

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Trihoney improves testicular weight change and histopathological alterations in hypercholesterolemic rabbits

Mohamed

Alfarisi

Wahab

et al. 2020

APJMBB

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Histopathological examination of testicular tissue is the most reliable and sensitive method for detecting effects on spermatogenesis. Hypercholesterolemia reduces testicular weight, induces testicular degenerative changes, impairs spermatogenesis, affects Leydig and Sertoli cells and induces inflammation and fibrosis of testicular tissue. Based on numerous studies, honey has the ability to improve testicular histopathological abnormalities. To date, whether honey has any protective role against the effects of hypercholesterolemia on male reproductive functions is yet to be explored. This study investigated the effects of Trihoney (a mixture of Trigona, Mellifera and Tualang honeys) on changes in testicular weight and histopathological alterations induced by hypercholesterolemia in male New Zealand white rabbits. These changes were compared with the effects of atorvastatin (a lipid lowering agent) based on the same parameters. Forty-eight male New Zealand white rabbits were assigned into 6 groups and received different diets as follows; Control: commercial pellet; CH: commercial pellet and 0.6 g/kg/day Trihoney; HCD: 1% cholesterol diet; DH1: 1% cholesterol diet and 0.3 g/kg/day Trihoney; DH2: 1% cholesterol diet and 0.6 g/kg/day Trihoney; DAt: 1% cholesterol diet and 2 mg/kg/day atorvastatin. After 12 weeks, blood samples were collected for lipid analysis, the rabbits were sacrificed and the testes were harvested to evaluate any weight and histopathological changes. Administration of 1% cholesterol diet either alone or in combination with atorvastatin caused a significant reduction in the testicular weight, testicular tubular degenerative changes and spermatogenesis impairment. Trihoney, particularly, at the dose of 0.6 g/kg/day improved testicular weight, ameliorated the testicular tubular degenerative changes and enhanced spermatogenesis. The findings of this study suggest that Trihoney plays a favourable role in the protection against testicular weight reduction and histopathological changes induced by hypercholesterolemia. On the other hand, atorvastatin per se may have toxic effects on testicular tissue.

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Protective role of Nigerian honey on sperm indices and testis in sucrose-fed rat

Cited by 3 publications

References 48 publications

Chemical Composition, Nutritional Functions, and Antioxidant Activities of Honeys in Africa

Chemical Composition, Nutritional Functions, and Antioxidant Activities of Honeys in Africa

Trihoney ameliorates hypercholesterolemia-induced epididymal histopathological changes in male rabbits

Trihoney improves testicular weight change and histopathological alterations in hypercholesterolemic rabbits

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