Protective Role of Onion (Allium cepa L.) on Caffeine Induced Spermatotoxicity in Albino Rats

Ekaluo, U. B.; Uno, U. U.; Edu, N. E.; Ekpo, Pattama; Etta, S.E.; Volunteer, B

doi:10.9734/jalsi/2016/23245

Cited by 4 publications

(5 citation statements)

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“…The weight of testes and epididymes, sperm count, motility and viability significantly (p<0.05) reduced in caffeinetreated animals when compared with the control. This agrees with the reports of Uno et al [31], Ekaluo et al [16,[24][25][26] who observed spermatotoxic effect of caffeine on sperm quality.…”

Section: Discussionsupporting

confidence: 93%

“…In humans, low and average doses of caffeine produce increase alertness and positive effects on the myocardium, while high doses cause caffeine dependency with a wide range of unpleasant physical and mental conditions such as nervousness, irritability, restlessness, insomnia, headache and heart palpitations [19]. Consumption of caffeine has also been linked with delayed conception [20], reproductive and developmental toxicities [21][22][23][24][25][26][27] and an increase in the frequency of sperm abnormalities [28].…”

Section: Introductionmentioning

confidence: 99%

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Ameliorating Potential of Honey on Caffeine Induced Sperm Toxicity in Male Albino Rats

Uno

Umoyen

Esua

et al. 2018

JABB

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This study evaluated the ameliorating effect of honey on caffeine-induced sperm toxicity in male albino rats. Thirty healthy male albino rats of 12 weeks old were divided into five groups with six rats in each group using a Completely Randomized Design (CRD). The experimental animals were treated with combinations of caffeine and honey orally. Group 1 served as the control and was given only water and feed; Group 2 (honey group) received 10 ml/kgBW of honey; Group 3 (caffeine group) received 200 mg/kgBW of caffeine; Group 4 (C + H 1 group) received 200 mg/kgBW of caffeine and 10 ml/kgBW of honey while Group 5 (C + H 2 ) received 20 ml/kgBW of honey and 200 mg/kgBW of caffeine. The treatments lasted for a period of 65 days. Results showed statistically significant (p<0.05) reduction in weight of testes and epididymis, epididymal sperm viability, motility and count in caffeine treated rats when compared with the control. There was a concomitant increase in sperm head abnormalities in caffeine treated rats. However, honey effectively ameliorated the caffeine induced sperm toxicities in albino rat models in a dosedependent manner.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Ameliorating Potential of Honey on Caffeine Induced Sperm Toxicity in Male Albino Rats

Uno

Umoyen

Esua

et al. 2018

JABB

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“…However, caffeine caused a significant (p<0.05) reduction in sperm motility, sperm viability and sperm count when compared with the control and other treatment groups. The effect of caffeine on the sperm parameters suggested spermatotoxic effect of caffeine on sperm quality and quantity was in line with the findings of Smith [20], Ekaluo et al [16] and Uno et al [21]. The significant reduction in sperm count, viability and motility could be due to deleterious effect of caffeine on spermatogenic processes in the animals.…”

Section: Discussionsupporting

confidence: 87%

“…Mutation index: Mutation index were calculated according to Ekaluo et al [16] using the following formula:…”

Section: Sperm Head Abnormalitymentioning

confidence: 99%

“…In man, minute and medium dosages of caffeine exert alertness and positively impact the myocardium, whereas the high dosages give rise dependency on caffeine with various unwanted mental and physical effects which give rise to irritability, nervousness, lack of rest, headache, loss of sleep, and palpitations of the heart [14]. Frequent intake of caffeine has been reportedly correlated with delay in conception, toxic effects on reproduction and development and advancement in the rate at which sperm abnormalities occur [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Attenuating Effect of Some Antioxidants on Caffeine Induced Spermatotoxicity and Mutagenicity in Male Albino Rats

Offiong

Uno

Ekaluo

2023

ARRB

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Background and Objective: Infertility is one of the major health problems in life and has been linked to several factors; therefore different approaches are required to address the problem. This study investigated the attenuating potential of some antioxidants: Cellgevity, Max one, purslane and Vitamin C on caffeine induced spermatotoxicity in male albino rats. Location and duration of Study: This study was carried in the Department of genetics and Biotechnology, University of Calabar, Calabar and lasted for sixty five days. Methodology: Sixty sexually matured male albino rats were randomly divided into ten groups consisting of two rats in three replicates using completely randomized design (CRD). Group one served as control and received water and feed only. Group two were given 200 mg/kgBw of Cellgevity, group three received 200 mg/kgBW of Max one, group four received 100 mg/kgBW of Vitamin C, group five received 200 mg/kgBW of caffeine, group six received 200mg/kgBW of purslane, group seven received 200 mg/kgBW of caffeine and 200 mg/kgBW of Cellgevity, group eight received 200 mg/kgBW of caffeine and 200 mg/kgBW of Max one, group nine received 200mg/kgBW of caffeine and 200 mg/kgBW of purslane, group ten received 200 mg/kgBW of caffeine and 100 mg/kgBW of vitamin C. Administration was done orally and lasted for 65days. The rats were sacrificed after administration using chloroform anaesthesia. Testes and epididymes were processed for testes and epididymal weights as well as sperm profile. Results: The results showed that caffeine significantly (p<0.05) negatively affected all the parameters studied. The sperm profile significantly reduced in caffeine treated animals. However, Cellgevity, Max one, purslane and Vitamin C attenuated the effect of caffeine in all the parameters evaluated by increased the sperm viability, sperm motility, sperm count and reduced sperm head abnormalities and mutation index in the combination groups. Conclusion: Results show that Cellgevity, Max one, purslane and Vitamin C have the potential to attenuate spermatotoxicity caused by caffeine in albino rats.

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Ameliorating Potential of Sesame (Sesamum indicum L.) On Caffeine Induced Sperm Toxicity in Male Albino Rats

Uno-Ubarei¹,

Ndif²,

Es³

et al. 2019

Asian J. of Biological Sciences

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Protective Role of Onion (Allium cepa L.) on Caffeine Induced Spermatotoxicity in Albino Rats

Cited by 4 publications

References 0 publications

Ameliorating Potential of Honey on Caffeine Induced Sperm Toxicity in Male Albino Rats

Ameliorating Potential of Honey on Caffeine Induced Sperm Toxicity in Male Albino Rats

Attenuating Effect of Some Antioxidants on Caffeine Induced Spermatotoxicity and Mutagenicity in Male Albino Rats

Ameliorating Potential of Sesame (Sesamum indicum L.) On Caffeine Induced Sperm Toxicity in Male Albino Rats

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