Protective Role of Royal Jelly Against Radiation-Induced Oxidative Stress in Rats

Cihan, Yasemin Benderli

doi:10.4999/uhod.11016

Cited by 21 publications

(20 citation statements)

References 24 publications

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“…Therefore, in the current study, we chose the 10‐day interval for formation of maximum tissue damage like Cihan et al . (). Also, the dosage of AG (100 mg kg −1 ) was selected according to related previous studies (Parlakpinar et al ., ; Xu et al ., ; Ozturk et al ., ).…”

Section: Methodsmentioning

confidence: 97%

Beneficial effects of aminoguanidine on radiotherapy-induced kidney and testis injury

et al. 2015

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This experimental study was designed to investigate both protective and therapeutic effects of aminoguanidine (AG), on radiotherapy (RT)-induced oxidative stress in kidney and testis. Forty rats were divided into five groups equally as follows: (i) control, (ii) RT, (iii) AG, (iv) AG+RT and (v) RT+AG group. Histopathological findings and biochemical evaluations, including tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), total oxidant status (TOS), total antioxidant capacity, oxidative stress index (OSI), blood urea nitrogen (BUN), serum creatinine (Cr) and testosterone levels, were determined. MDA, TOS and OSI were significantly higher in RT-treated groups, whereas SOD, CAT, GPX and GSH were significantly lower in these groups when compared with the control rats in the kidney and testis tissue. AG treatment significantly decreased MDA, TOS and OSI levels and increased SOD, CAT, GPX and GSH levels, when compared to the RT-treated groups in both kidney and testis tissue. BUN and Cr levels did not change among the groups, whereas testosterone levels were found as reduced in the RT-treated rats. AG treatment significantly augmented these hazardous effects of RT on testis tissue. According to our results, AG has beneficial effects against RT-induced kidney and testis injury.

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Section: Methodsmentioning

confidence: 97%

Beneficial effects of aminoguanidine on radiotherapy-induced kidney and testis injury

et al. 2015

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“…After rats exposed to cisplatin and carbon tetrachloride, RJ administration could resist against oxidative stress in liver and renal tissues, which is achieved by decreasing MDA production and increasing the concentration of cellular antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), and glutathione peroxidase (GPx) [122]. In radiation-induced lung and liver damage of Sprague-Dawley rats, pre-and post-administration of RJ are effective in reducing oxidative stress and increasing antioxidant properties [74]. The antioxidant response of enzyme-treated RJ (ERJ) is confirmed by the reduction of nitric oxide (NO) and intracellular reactive oxidative species, and increased the effect of the antioxidant glutathione and antioxidant SOD levels.…”

Section: Antioxidant Activitymentioning

confidence: 99%

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Ahmad

Campos

Fratini

et al. 2020

IJMS

169

134

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Royal jelly (RJ) is a yellowish-white and acidic secretion of hypopharyngeal and mandibular glands of nurse bees used to feed young worker larvae during the first three days and the entire life of queen bees. RJ is one of the most appreciated and valued natural product which has been mainly used in traditional medicines, health foods, and cosmetics for a long time in different parts of the world. It is also the most studied bee product, aimed at unravelling its bioactivities, such as antimicrobial, antioxidant, anti-aging, immunomodulatory, and general tonic action against laboratory animals, microbial organisms, farm animals, and clinical trials. It is commonly used to supplement various diseases, including cancer, diabetes, cardiovascular, and Alzheimer’s disease. Here, we highlight the recent research advances on the main bioactive compounds of RJ, such as proteins, peptides, fatty acids, and phenolics, for a comprehensive understanding of the biochemistry, biological, and pharmaceutical responses to human health promotion and life benefits. This is potentially important to gain novel insight into the biological and pharmaceutical properties of RJ.

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“…injected with three separate administration of DEN (200 mg/kg body weight, dissolved in olive oil), on the zero, fifteenth and thirtieth treatment day of the 16-week experimental period (13). DEN+RJ group fed with water supplemented with 100 mg/kg of RJ (14), DEN+GSE group fed with water supplemented with 100 mg/kg of GSE (15,16), DEN+LBAE group fed with water supplemented with 400 mg/kg of LBAE (17,18) from day 0 for 16 weeks. RJ, GSE and LBAE were added to the daily drinking water.…”

Section: Experimental Designmentioning

confidence: 99%

Hepatoprotective effect of royal jelly, grape seed extract, and Lycium barbarum against diethylnitrosamine-induced liver toxicity in rats

Bilğiç¹,

Doğan²,

Azırak³

et al. 2018

Ann Med Res

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We aimed to investigate, the effects of royal jelly (RJ), grape seed extract (GSE), and Lycium barbarum extract (LBAE) against diethylnitrosamine (DEN) induced hepatotoxicity, in experimental animal model. Material and Methods: Fifty female Sprague Dawley rats were divided into five groups (n=10): Control, DEN, DEN+RJ, DEN+GSE, DEN+LBAE. DEN administrated groups were intraperitoneally (i.p.) injected with three separate administration of DEN (200 mg/kg), on the zero, fifteenth and thirtieth treatment day. Then 100 mg/kg of RJ was given to DEN+RJ group, 100 mg/kg of GSE was given to DEN+GSE group, and 400 mg/kg LBAE was given to DEN+LBAE group with the daily drinking water from day 0 for 16 weeks. Histopathologic alterations including apoptotic changes of liver were evaluated. Results: RJ, GSE, and LBAE treatments significantly reduced weight loss induced by DEN. DEN administrated rats significantly increases malondialdehyde (MDA) level. It also efficiently decreases glutathione (GSH) level and catalase (CAT), superoxide dismutase (SOD) activity. These results were significantly ameliorated by dietary supplements (p<0.05). In addition, they increased the total antioxidant status (TAS) level and decreased serum oxidative stress index (OSI), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma glutamyl transpeptidase (GGT) levels significantly (p<0.05). TUNEL positive cells were extremly pervasive in the livers of DEN group. Conclusion: Improvements were prominent in case of RJ > GSE > LBAE. Our results indicated that RJ, GSE and LBAE might be useful for prevention of hepatotoxicity induced by DEN via ameliorative effects on biochemical and oxidative stress indices.

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Protective Role of Royal Jelly Against Radiation-Induced Oxidative Stress in Rats

Cited by 21 publications

References 24 publications

Beneficial effects of aminoguanidine on radiotherapy-induced kidney and testis injury

Beneficial effects of aminoguanidine on radiotherapy-induced kidney and testis injury

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Hepatoprotective effect of royal jelly, grape seed extract, and Lycium barbarum against diethylnitrosamine-induced liver toxicity in rats

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