Protective Role of Seed Extract of Tephrosia purpurea in Letrozole Induced Polycystic Ovary Syndrome in Wistar Rats

Basheer, Muddasir; Rai, Seema; Ghosh, Hindole; Hajam, Younis Ahmad

doi:10.3923/jbs.2018.458.467

Cited by 5 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The weight of the right and left ovaries and the weight of the uterus was found to be increased in the induced group and decreased in treatment and referral groups. These changes have also been observed in other studies [23][24][25][26][27]. Nevertheless, the uterine mass was reduced in the treatment group compared to that of the referral group in our study.…”

Section: Discussionsupporting

confidence: 91%

Regulation of estrous cycle by Cynodon dactylon in letrozole induced polycystic ovarian syndrome in Wistars albino rats

Nallathambi

Bhargavan

2019

Anat Cell Biol

View full text Add to dashboard Cite

Menstrual cycle is controlled by luteinizing hormone (LH) and follicle-stimulating hormone of anterior pituitary and regulated by gonadotropin-releasing hormone of hypothalamus. Any disturbance to this regulatory mechanism alters the pulsatile release of these hormones, especially LH; leads to polycystic ovarian syndrome (PCOS). Changes in vaginal cytology are used to interpret the changes in hormonal levels and modifications in estrous cycle. The aim of this study is to compare the pattern of vaginal cytology and body mass among PCOS rats which are treated with metformin and Cynodon dactylon. Twentyfour Wistar rats were selected and divided into four groups: control, induced, treatment, and referral. PCOS was induced in all groups except controls by giving letrozole through oral gavage for 21 days. After inducing PCOS, the referral and treatment group were treated for PCOS with metformin and C. dactylon respectively for next 21 days. Vaginal smear of all the groups were taken every day from day one and screened for estrous cycle. The body mass of the animals was measured on days 1, 21, and 42. Animals were sacrificed after 24 hours of the last dose and the reproductive organs were dissected out and weighed. Results of the study show the estrous cycle begins to revert after 1-week administration of C. dactylon; while the changes were slower in referral group. There was a rapid decrease in the body mass as well as reproductive organs among the treatment and referral group compared to that of induced and control. Finding of this study suggests that C. dactylon treats PCOS better than metformin.

show abstract

Section: Discussionsupporting

confidence: 91%

Regulation of estrous cycle by Cynodon dactylon in letrozole induced polycystic ovarian syndrome in Wistars albino rats

Nallathambi

Bhargavan

2019

Anat Cell Biol

View full text Add to dashboard Cite

show abstract

“… 46 Due to the increased levels of androgens, there is follicular atresia and abnormal follicular development in the ovary. 42 …”

Section: Discussionmentioning

confidence: 99%

“… 41 Biochemical Parameters: Serum glucose, triglycerides, total cholesterol, HDL, Triglycerides, Serum estradiol, progesterone, testosterone and FSH:LH ratio were evaluated. 42 Histopathology of the ovary: On the 50th day of the study, both ovaries were collected from each animal. It was removed, cleaned up and weighed.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Beneficial effect of polyherbal formulation in letrozole induced Polycystic ovarian syndrome (PCOS)

Prajapati

Patel²,

Dharamsi³

2022

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

“…5 This condition is characterized by an excess of ovarian androgen production from numerous small follicles, anovulation, and insulin resistance in the reproductive life span of females. 6 Therefore, higher androgen level is the main marker of PCOS patients. 7 In women with PCOS, infertility could result from impaired ovarian folliculogenesis.…”

Section: Introductionmentioning

confidence: 99%

Histomorphometric and biochemical activities of bioactive component of Cyperus esculentus tubers extract on letrozole-induced polycystic ovarian syndrome and cholesterol homeostasis in female Sprague-Dawley rats

Adelakun

Ojewale

Jeje

et al. 2022

Toxicology Research and Application

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder, causes irregular menstrual cycles, dyslipidemia, excessive body weight, oxidative stress, hyperandrogenism, and infertility. This study focused on the impact of Cyperus esculentus (CES) on letrozole-induced PCOS in female Sprague-Dawley rats. Twenty (20) normal rats and twenty (20) PCOS rats (150–200 g, 8 weeks old) were randomly divided into four groups of ten ( n = 10) rats each. Group A served as normal control group received 2 mL of normal saline, group B treated with 500 mg/kg body weight of CES , group C PCOS control group received 2 mL of normal saline, and group D PCOS rats post-treated with 500 mg/kg body weight of CES daily through gastric gavage for 30 days. Estrus cyclicity, body and ovaries weights, biochemical and histological parameters were measured. Observed irregular estrus cyclicity and multiple cysts in PCOS rats, increase glycemia, ovarian weight, triglycerides, total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, malondialdehyde, luteinizing hormone (LH), testosterone, and decrease high-density lipoprotein cholesterol, estradiol, progesterone, catalase, reduced glutathione (GSH), and superoxide dismutase levels, compared with control. The intervention of CES ameliorated and restored the estrus cyclicity reproductive hormone, biochemical, and structural alterations. Moreover, CES significantly decreased cystic follicles, LH, and testosterone levels, but increased estradiol concentration. This plant may be beneficial in the management and treatment of PCOS-related reproductive and metabolic disorders.

show abstract

Protective Role of Seed Extract of Tephrosia purpurea in Letrozole Induced Polycystic Ovary Syndrome in Wistar Rats

Cited by 5 publications

References 31 publications

Regulation of estrous cycle by Cynodon dactylon in letrozole induced polycystic ovarian syndrome in Wistars albino rats

Regulation of estrous cycle by Cynodon dactylon in letrozole induced polycystic ovarian syndrome in Wistars albino rats

Beneficial effect of polyherbal formulation in letrozole induced Polycystic ovarian syndrome (PCOS)

Histomorphometric and biochemical activities of bioactive component of Cyperus esculentus tubers extract on letrozole-induced polycystic ovarian syndrome and cholesterol homeostasis in female Sprague-Dawley rats

Contact Info

Product

Resources

About