Protective role of sildenafil citrate in isoniazid-rifampicin induced histomorphological changes in liver of albino mice

Hameed, Najma; Farooq, Khalid

doi:10.2399/ana.21.829636

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Hameed and Farooq [26] also found significant improvement in histological parameters of the liver in mice treated with SC for 21 days.…”

Section: Resultsmentioning

confidence: 81%

The Potential Effect of Sildenafil Citrate on Some Hematological and Biochemical Parameters in Hyperglycemic Rats

Hussein¹

2022

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Sildenafil citrate (SC) is a phosphodiesterase type-5 inhibitor, which acts to increase cyclic guanosine monophosphate (cGMP). This study aims to assess the effects of Sildenafil citrate (SC) on glycemic control and hematological parameters of diabetic rats induced with streptozotocin (STZ). Fifty male Wistar rats were divided into four groups (n=10/non-diabetic group; n=15/diabetic group): i. control (I), ii. SC-treated control (II), iii. diabetic (III), and iv. SC-treated diabetic (IV). Diabetes was induced by an intraperitoneal injection of STZ (50 mg/kg). SC (20 mg/kg body weight) was administered orally for six weeks. Blood specimens were taken to measure levels of serum glucose (FBG), insulin, glycated hemoglobin (HbA1c), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, prothrombin time (PT), partial thromboplastin time (aPTT), fibrinogen, protein C, and protein S. Levels of FBG, HbA1c, AST, ALT, urea, creatinine, and fibrinogen were significantly elevated in the rats with diabetes compared to the controls. Conversely, insulin, aPTT, protein C and S were significantly lower in the diabetic groups. No significant difference was seen in the PT of control and diabetic rats. No effect was found in the administration of SC on healthy control rats. Upon administration of SC to the diabetic rats, these parameters returned to normal (P<0.05). SC was found to improve glycemic control as well as microcirculatory perfusions in diabetic rats, warranting its consideration as a way to lessen diabetic complications.

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“…Hameed and Farooq [26] also found significant improvement in histological parameters of the liver in mice treated with SC for 21 days.…”

Section: Resultsmentioning

confidence: 81%

The Potential Effect of Sildenafil Citrate on Some Hematological and Biochemical Parameters in Hyperglycemic Rats

Hussein¹

2022

Pharmacophore

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“…The results are in agreement with the works of Ibama et al [30], in which the administration of sildenafil and revive capsules were seen not to be hepatotoxic. Sildenafil citrate has been reported to reverse biochemical/histopathological changes in the liver due to jaundice and offer hepatoprotective action against drug-induced hepatotoxicity [31,32]. Some other studies have however reported hepatotoxic effects of increasing doses of sildenafil and the combination of sildenafil and tramadol in experimental models [1,33].…”

Section: Resultsmentioning

confidence: 99%

Effects of combination of tramadol and sildenafil citrate (Viagra) on hepatic and renal function parameters in Male Albino Rats

Ojoye N. Briggs,

Kemzi N. Elechi-Amadi,

Jack G. Tetam

et al. 2024

World J. Bio. Pharm. Health Sci.

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Erectile dysfunction, premature ejaculation and pleasure seeking have increased the use of sildenafil citrate, tramadol and their combination by youths who believe these drugs could positively impact their sexual life. Sildenafil citrate and tramadol are metabolized in the liver, and their by-products excreted through the kidneys, making these organs possible targets for toxicity. Aim: This study evaluates the effects of combination of tramadol and sildenafil citrate on hepatic and renal function parameters in male albino rats. Methodology: A total of forty-nine (49) male albino rats weighing between 150 to 180g were used for the study. Sildenafil citrate and tramadol were administered to the rats by means of oral gavage for 28 days. The liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined using the Reitman-Frankel method. Alkaline phosphatase (ALP) was determined using the Colorimetric endpoint method. Total protein (TP) was determined using the biuret method. Albumin (ALB) was determined using the bromocresol green method. Sodium (Na+), potassium (K+) and chloride (CL-) were determined using ion selective electrode (ISE) method. Bicarbonate (HCO3-) was determined using titrimetric method. Urea was determined using Urease bertholet method. Creatinine was determined using Jaffe-Slot method. Results: There were no significant differences (P>.05) in the liver enzymes ALT, AST and ALP in all the treatment groups compared to the negative control. Total protein (TP) and albumin (ALB) also showed no significant differences (P>.05) in the groups, compared to the negative control. there were no significant differences (P>.05) in the electrolyte levels in the treatment groups, compared to the negative control. Urea and creatinine levels were also not significantly different (P>.05) in the treatment groups, compared to the negative control. Conclusion: Administration of sildenafil citrate singularly and in combination with tramadol, at recommended and double doses for 28 days, did not impact the liver and was also non-toxic to the kidneys.

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Sildenafil and Vitamin E Alone or in Combination Suppresses Cyclophosphamide-Induced Hepatotoxicity in Rats Through Antioxidant Mechanisms

Nikbakht,

Panahi Kokhdan,

Sadeghi

et al. 2024

Jundishapur J Nat Pharm Prod

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Background: Cyclophosphamide (CP) can induce severe hepatotoxicity in certain patients by generating oxidative molecules and increasing reactive oxygen species (ROS). There are limited reports on the antioxidant and anti-inflammatory properties of Sildenafil. Objectives: This study aimed to evaluate the effect of Sildenafil on CP-induced hepatotoxicity. Methods: Animals were randomly divided into five groups (n = 6): Group I (control) received water distillate by gavage. Group II received CP (200 mg/kg) intraperitoneally to induce hepatotoxicity. Group III was orally administered Sildenafil (75 mg/kg) along with CP (200 mg/kg), while Group IV received vitamin E (500 mg/kg) and CP (200 mg/kg). Group V was administered 75 mg/kg of Sildenafil, 200 mg/kg of CP, and 500 mg/kg of vitamin E. At the end of the experiment, blood samples were collected from the animals' hearts to measure serum levels of liver enzymes, including aspartate transaminase (AST) and alanine aminotransferase (ALT), as well as oxidative stress markers malondialdehyde (MDA), nitric oxide (NO), and ferric reducing antioxidant power (FRAP). Liver tissue was also collected for assessment of antioxidant enzyme activity, including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx), along with histological examination. Results: The CP-treated group exhibited significant increases in AST, ALT, MDA, and NO levels, while CAT, SOD, GPx, and FRAP levels were markedly lower in the CP group compared to the saline group (P ≤ 0.01). Administration of sildenafil, alone and in combination with vitamin E, significantly reduced levels of AST, ALT, MDA, and NO. Meanwhile, antioxidant enzyme activity was markedly enhanced following sildenafil and vitamin E intake (P ≤ 0.01). Additionally, histological analysis confirmed Sildenafil's hepatoprotective properties. Conclusions: This study demonstrated that Sildenafil, both alone and in combination with vitamin E, was effective in reducing CP-induced liver toxicity through antioxidant mechanisms. Therefore, these findings suggest that Sildenafil, especially when combined with vitamin E, may serve as a complementary therapy to mitigate the hepatotoxic effects of CP.

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Protective role of sildenafil citrate in isoniazid-rifampicin induced histomorphological changes in liver of albino mice

Cited by 3 publications

References 16 publications

The Potential Effect of Sildenafil Citrate on Some Hematological and Biochemical Parameters in Hyperglycemic Rats

The Potential Effect of Sildenafil Citrate on Some Hematological and Biochemical Parameters in Hyperglycemic Rats

Effects of combination of tramadol and sildenafil citrate (Viagra) on hepatic and renal function parameters in Male Albino Rats

Sildenafil and Vitamin E Alone or in Combination Suppresses Cyclophosphamide-Induced Hepatotoxicity in Rats Through Antioxidant Mechanisms

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