Protective Role of Zinc and Magnesium against Cadmium Nephrotoxicity in Male Wistar Rats

Babaknejad, Nasim; Moshtaghie, Ali Asghar; Nayeri, Hashem; Hani, Mohsen; Bahrami, Somaye

doi:10.1007/s12011-016-0671-x

Cited by 33 publications

(21 citation statements)

References 41 publications

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“…It is well established that the toxicity of cadmium promotes an imbalance in antioxidant defense system, reducing the endogenous antioxidant enzymatic activity, such as superoxide dismutase and catalase [40]. Our results showed that cadmium impairs the gene expression of CuZn-SOD and catalase.…”

Section: Discussionsupporting

confidence: 54%

Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats

et al. 2020

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Background The objective of this study was to evaluate protective effect of grape and apple juices against toxicity induced by cadmium in the kidney of rats. Methods A total of 20 male-Wistar rats were distributed into four groups (n=5): Control group: animals received an intraperitoneal (i.p.) injection of 0.9% saline solution and after 15 days, 1 mL of water was administered for 15 days, via gavage; Cadmium group: animals received an intraperitoneal injection of cadmium chloride (1.2 mg/kg) and after 15 days, 1 mL of water was administered for 15 days via gavage; Cadmium+Grape Juice: animals received an i.p. injection of cadmium chloride (1.2 mg/kg), and after 15 days, 0.8 mL of grape juice was administered for 15 days, via gavage; Cadmium+Apple Juice: animals received i.p. injection of cadmium chloride (1.2 mg/kg) and after 15 days, 1.0 mL of apple juice was administered for 15 days, via gavage. Results Histopathological analysis revealed severe tubular lesion and necrosis in the group exposed to cadmium, while animals exposed to grape or apple juices showed a significant reduction of tissue injury. 8-OHdG immunoexpression, DNA damage, cytochrome C and catalase gene expressions and Toll like signaling pathway (TLR2, and pIKKα/β) decreased in animals treated with grape juice when compared to cadmium group. Conclusion Taken together, we conclude that grape and apple juices had a protective effect by means of antioxidant, antigenotoxic actions and for promoting tissue regeneration in the kidney of rats following cadmium intoxication.

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Section: Discussionsupporting

confidence: 54%

Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats

et al. 2020

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“…Indeed, it has been suggested that long-term exposure to Cd exacerbates the CKD-related decline in GFR [179,180,181,182]. Moreover, exposure to Cd or other nephrotoxicants may further reduce or completely eliminate the renal functional reserve and the ability of the remaining functional renal mass to maintain normal homeostasis when challenged [12,183,184,185]. Indeed, Sprague-Dawley rats exposed chronically to oral Cd have been shown to have less renal functional reserve than unexposed rats [12].…”

Section: Environmentally Relevant Toxic Metalsmentioning

confidence: 99%

Chronic Kidney Disease and Exposure to Nephrotoxic Metals

Orr

Bridges

2017

IJMS

307

110

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Chronic kidney disease (CKD) is a common progressive disease that is typically characterized by the permanent loss of functional nephrons. As injured nephrons become sclerotic and die, the remaining healthy nephrons undergo numerous structural, molecular, and functional changes in an attempt to compensate for the loss of diseased nephrons. These compensatory changes enable the kidney to maintain fluid and solute homeostasis until approximately 75% of nephrons are lost. As CKD continues to progress, glomerular filtration rate decreases, and remaining nephrons are unable to effectively eliminate metabolic wastes and environmental toxicants from the body. This inability may enhance mortality and/or morbidity of an individual. Environmental toxicants of particular concern are arsenic, cadmium, lead, and mercury. Since these metals are present throughout the environment and exposure to one or more of these metals is unavoidable, it is important that the way in which these metals are handled by target organs in normal and disease states is understood completely.

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“…In fact, a tendency toward the decrease in the weight of the kidneys was observed, especially in males. This alteration has been related to nephrotoxicity, such as necrosis and degenerative damage (Babaknejad, Moshtaghie, Nayeri, Hani, & Bahrami, ), which was confirmed by histopathological and biochemical findings, as described below.…”

Section: Resultsmentioning

confidence: 60%

Investigation of the Antibacterial Activity and Subacute Toxicity of a Quercus crassifolia Polyphenolic Bark Extract for its Potential Use in Functional Foods

Valencia-Avilés

Martínez-Flores

Garcı̀a-Pèrez

et al. 2019

Journal of Food Science

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Oak wood is used in barrels for wine aging. During aging, polyphenols are transferred from the barrels to the liquid. Although the bioactivity of oak polyphenols in wines has been extensively studied, no investigation exists on their toxicological properties, which limits their use as functional safe ingredients for other products. In this work, the chemical composition of a polyphenolic extract of Quercus crassifolia bark (QCBe) was studied by GC‐MS. Its antibacterial properties on probiotic and pathogenic bacteria and its subacute‐oral toxicity were determined as a way to understand the potential impact from its addition to fermented food as a functional ingredient. QCBe shows a selective inhibition of Escherichia coli compared with Lactobacillus bulgaricus and Streptococcus thermophylus. According to the toxicity evaluation, the subacute no‐observed‐adverse‐effect‐level was achieved at 11 mg/kg bw/day, whereas the subacute lowest‐observed‐adverse‐effect‐level for kidney damage was at 33 mg/kg bw/day. These results suggest that, given the fact an adverse effect was observed after subacute administration of this extract, further longer term toxicological studies are needed to provide sufficient safety evidence for its use in humans. Practical Application Mexico's yogurt market is growing which creates opportunities for the development of some yogurt products as functional foods. As a first step to evaluate its potential use in yogurt formulation, the antibacterial effect of a Quercus crassifolia polyphenolic extract (QCBe) on probiotic bacteria and its subacute‐oral toxicity in rats were studied. A low inhibition on probiotic bacteria growth was observed after QCBe addition to Lactobacillus bulgaricus and Streptococcus thermophylus cultures. Exposure to QCBe for a subacute duration resulted in renal injury in rats at dosages greater than or equal to 33 mg/kg/bw/day. This adverse effect indicates the importance of performing further long‐term toxicological assessments prior to the addition of QCBe to a food like yogurt, which is regularly eaten by consumers.

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Protective Role of Zinc and Magnesium against Cadmium Nephrotoxicity in Male Wistar Rats

Cited by 33 publications

References 41 publications

Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats

Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats

Chronic Kidney Disease and Exposure to Nephrotoxic Metals

Investigation of the Antibacterial Activity and Subacute Toxicity of a Quercus crassifolia Polyphenolic Bark Extract for its Potential Use in Functional Foods

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