Protective Value of a Folkloric Medicinal Plant Extract Against Mortality and Hemorrhage in a Life-threatening Renal Trauma Model

Tokgöz, Hüsnü; Karakaya, Kemal; Hancı, Volkan; Abduşoğlu, Mustafa; Erol, Bülent; Türksoy, Özlem; Akduman, Bülent; Mungan, N.A.

doi:10.1016/j.urology.2009.12.016

Cited by 15 publications

(16 citation statements)

References 28 publications

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“…This finding has been observed also by other researchers [12,36] and is believed to be due to the formation of an encapsulated protein network causing delayed degradation of erythrocytes and later hemosiderin-loaded histiocyte accumulation [12] . TCC is a naturally occurring peptide-copper complex that has been shown to possess potentially interesting properties in the wound healing process in animal [21,37] and human models [20,38] .…”

Section: Gül Satar Cangül Topalsupporting

confidence: 79%

Ankaferd Blood Stopper (ABS) ve Topikal Tripeptid Bakır Kompleksinin (TCC) Ratlarda Yara İyileşmesi Üzerine Etkisi: Deneysel Çalışma

Satar¹,

Cangül²,

Topal³

et al. 2014

Kafkas Univ Vet Fak Derg

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We investigated the effects of Ankaferd Blood Stopper (ABS) and tripeptide copper complex (TCC) on wound healing in rats. A total of 24 outbred, male, Sprague-Dawley rats were randomly divided into (1) ABS, (2) TCC, and (3) control groups. Bilateral experimental wounds were created near the caudal border of the scapula. Each wound in the respective treatment group was treated daily with sponges soaked in ABS solution, topical TCC gel, or saline. On days 0, 7, 14 and 21, unhealed wound area was measured and biopsy samples were taken for histopathological analysis (except day 0). Median time for the first observable granulation tissue was not significantly different in the ABS, TCC, and control groups (5.8, 5.5, and 6.7 days, respectively) (P>0.05). Filling of the open wound with granulation tissue to skin level was significantly slower in the control group than in the ABS and TCC groups (18, 9, and 11 days, respectively). The mean unhealed wound area was significantly smaller and the mean percentage of total wound healing was significantly higher in the ABS-and TCC-treated wounds than in the control wounds on day 7, 14, and 21 (P<0.05); the average time for healing was also significantly shorter in the treatment groups than in the control group (17.4, 16.8 vs. 23.6 days, respectively) (P<0.05). Our results suggest that topical application of ABS and TCC have beneficial effects on wound healing. Keywords: Wound healing, Ankaferd Blood Stopper (ABS), Tripeptide copper complex (TCC), Skin, Rat Ankaferd Blood Stopper (ABS) ve Topikal Tripeptid Bakır Kompleksinin (TCC) Ratlarda Yara İyileşmesi Üzerine Etkisi:Deneysel Çalışma ÖzetBu çalışmada, Ankaferd Blood Stopper (ABS) ve tripeptid bakır kompleksinin (TCC) ratlarda yara iyileşmesi üzerine etkilerinin araştırılması amaçlanmıştır. Sprague-Dawley ırkı, dişi, 24 adet rat, rastgele şekilde 1) ABS, 2) TCC, ve 3) Kontrol olmak üzere 3 gruba ayrıldı. Skapulanın kaudal sınırına yakın sahada bilateral deneysel yaralar oluşturuldu. Her bir yara günlük olarak grubuna göre ABS solüsyon emdirilmiş sponjlar, topikal TCC jel ya da serum fizyolojik ile tedavi edildi. İyileşmemiş yara alanı 0, 7, 14 ve 21. günlerde ölçüldü ve histopatolojik analiz için biyopsi örnekleri alındı (0. gün haricinde). İlk gözlenebilir granulasyon dokusu oluşumu ortalama zamanı açısından ABS, TCC ve kontrol grupları arasında anlamlı istatistiki fark yoktu (sırasıyla 5.8, 5.5 ve 6.7 gün) (P>0.05). Açık yara sahasının deri düzeyine kadar granulasyon dokusu ile dolma süresi, kontrol grubunda ABS ve TCC grubundan anlamlı şekilde daha düşüktü (sırasıyla 18, 9 ve 11 gün). ABS ve TCC ile tedavi edilen yaraların 7, 14 ve 21. günlerde yapılan ölçümlerinde ortalama iyileşmemiş yara sahasının kontrol grubuna kıyasla anlamlı şekilde daha küçük ve ortalama total yara iyileşme yüzdesinin kontrol grubuna göre anlamlı şekilde daha büyük olduğu gözlendi (P<0.05); ortalama iyileşme zamanı da uygulama yapılan gruplarda kontrol grubundan anlamlı şekilde daha kısa (sırasıyla 17.4, 16.8 ve 23.6 gün) (P<0.05) olarak bulundu. Eld...

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Section: Gül Satar Cangül Topalsupporting

confidence: 79%

Ankaferd Blood Stopper (ABS) ve Topikal Tripeptid Bakır Kompleksinin (TCC) Ratlarda Yara İyileşmesi Üzerine Etkisi: Deneysel Çalışma

Satar¹,

Cangül²,

Topal³

et al. 2014

Kafkas Univ Vet Fak Derg

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“…However, as the product is relatively new, a limited amount of data is available related to long-term side effects and toxicity [1,21]. …”

Section: Discussionmentioning

confidence: 99%

Demonstration of the histopathological and immunohistochemical effects of a novel hemostatic agent, ankaferd blood stopper, on vascular tissue in a rat aortic bleeding model

Kandemir

Büyükateş

Kandemır

et al. 2010

J Cardiothorac Surg

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BackgroundAnkaferd Blood Stopper® (ABS) is a folkloric medicinal plant extract used as a hemostatic agent in traditional Turkish medicine. This experimental study investigated the histopathological and immunohistochemical effects of ABS on vascular tissue in a rat model of aortic bleeding.MethodsFour groups of 11 Wistar albino rats were used. The abdominal aortas of the rats were wounded; an ABS-soaked tampon was applied to rats in Groups 1 and 3, and a plain gauze tampon was applied to rats in Groups 2 and 4 until the bleeding stopped. The bleeding time was recorded. Immediately following sacrificing, the arteriotomy sites from Groups 1 and 2 were removed. The abdominal incisions in Groups 3 and 4 were closed following hemostasis. On Day 7 of the study, Group 3 and 4 rats were sacrificed and the abdominal aorta arteriotomy sites were removed for histopathological and immunohistochemical evaluation.ResultsThe mean bleeding time in 15 animals in Groups 2 and 4 was 4.9 ± 0.6 s, and in 22 animals in Groups 1 and 3 was 3.1 ± 0.6 s. Distal aortic occlusion was not observed on either Day 1 or 7 in any group. Significantly more widespread and dense endothelial nitric oxide synthase (eNOS) staining was observed in Group 1 animals than Group 2. On Days 1 and 7 after application of ABS, histopathological changes, consisting of necrosis, inflammation, and endothelial cell loss, in the rat abdominal aortas did not differ between Groups 1 and 2. The basophilic discoloration in the ABS group on the operation day was a result of a foreign body reaction and hemosiderin-loaded histiocyte accumulation, which occurred on Day 7.ConclusionsIn this study, hemostasis was successfully achieved with ABS in rat abdominal aortas. No histopathological change was found in the rat abdominal aortas between the ABS and control groups on Days 1 and 7. Further studies on the long-term effects of foreign body reactions and hemosiderin-loaded histiocyte accumulation are required.

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“…ABS'nin sıçanlarda karaciğer parsiyel rezeksiyonunda dikiş materyali ile karşılaştırılmasında, karaciğer laserasyon modelinde ve intravenöz heparin antikoagülan uygulanmış parsiyel nefrektomili sıçanlar-da, oxidized cellulose (Surgicel) ile karşılaştırılma-sında eşit hemostatik etkinlikte olduğu, fibrozis, enflamasyon ve doku hasarı meydana getirmediği göste-rilmiştir. [26][27][28] ABS'nin klinik olarak endoskopik uygulamalarda gastrointestinal kanalda hepatikojejunostomi, Dieulafoy lezyonu ve soliter rektal ülser kanamalarında etkin olduğu gösterilmiştir. [29][30][31][32] Bu bulgular bize ABS'nin FY gibi laparoskopik ve endoskopik cerrahi işlemler-de kullanılabileceğini düşündürdü.…”

Section: Discussionunclassified

Comparison of the hemostatic efficiency of Ankaferd Blood Stopper and fibrin glue on a liver laceration model in rats

Akarsu¹,

Kalaycı²,

Yavuz³

et al. 2011

Ulus Travma Acil Cerrahi Derg

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Protective Value of a Folkloric Medicinal Plant Extract Against Mortality and Hemorrhage in a Life-threatening Renal Trauma Model

Cited by 15 publications

References 28 publications

Ankaferd Blood Stopper (ABS) ve Topikal Tripeptid Bakır Kompleksinin (TCC) Ratlarda Yara İyileşmesi Üzerine Etkisi: Deneysel Çalışma

Ankaferd Blood Stopper (ABS) ve Topikal Tripeptid Bakır Kompleksinin (TCC) Ratlarda Yara İyileşmesi Üzerine Etkisi: Deneysel Çalışma

Demonstration of the histopathological and immunohistochemical effects of a novel hemostatic agent, ankaferd blood stopper, on vascular tissue in a rat aortic bleeding model

Comparison of the hemostatic efficiency of Ankaferd Blood Stopper and fibrin glue on a liver laceration model in rats

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