Protective value of dietary copper and iron against some toxic effects of lead in rats.

Klauder, David S.; Petering, Harold G.

doi:10.1289/ehp.751277

Cited by 66 publications

(11 citation statements)

References 11 publications

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“…Metabolic studies have shown that low intake of iron, calcium, vitamin D, and vitamin C may enhance the intestinal absorption and tissue retention of lead, resulting in increased lead toxicity (Barton et al 1978a(Barton et al , 1978bEdelstein et al 1984;Hamilton 1978;Hammad et al 1996 al. 1989;Hsu et al 1975;Klauder and Petering 1975;Mahaffey and Goyer 1972;Ragan 1977;Singh et al 1991;Six and Goyer 1970;Sobel and Burger 1955;Suzuki and Yoshida 1979). The lack of consistency between the results of this study with previous reports may be due to a number of reasons.…”

Section: Discussionmentioning

confidence: 41%

Influence of nutrient intake on blood lead levels of young children at risk for lead poisoning.

Gallicchio

Scherer

Sexton

2002

Environ Health Perspect

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Although removal of lead paint hazards from at-risk houses remains the primary means of preventing elevated blood lead among young children, reduction of risk through nutritional factors has also been of interest. In this study we evaluated the effect of nutrient intake on blood lead levels by analyzing whether the intakes of certain dietary components a) were associated with blood lead levels independent of lead exposure or b) modified the effect of lead exposure on blood lead. Subjects were 205 children from low-income families who were approximately 1 year of age and living in old, urban houses. The data collected for each child included blood lead level, nutritional status, and amount of lead exposure, which was assessed from samples of household dust. Multiple linear regression analyses showed a statistically significant positive association between lead exposure and blood lead. Statistically significant positive associations were found between blood lead and total fat as well as blood lead and saturated fat, independent of lead exposure and age of the child. Regression modeling and stratified analysis showed that mean blood lead increased with increasing lead exposure as well as with increasing caloric intake, suggesting that caloric intake modifies the association between lead exposure and blood lead. The findings from this study, if replicated in other studies, support a dietary intervention to reduce the amount of total calories, total fat, and saturated fat among children 1 year of age at risk for lead exposure, while maintaining adequate intake of these dietary components. Our results also reinforce recommendations that removal of lead paint hazards from at-risk houses should be the primary means of preventing lead exposure.

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Section: Discussionmentioning

confidence: 41%

Influence of nutrient intake on blood lead levels of young children at risk for lead poisoning.

Gallicchio

Scherer

Sexton

2002

Environ Health Perspect

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“…Copper is a component of the mitochondrial electron transport chain and maintenance of neurotransmitter levels in the brain 122,123) . Adequate intake of copper provides protection against lead, whereas higher intake of copper increases lead absorption [124][125][126][127] . The above studies clearly suggest that these micronutrients play a role in preventing toxic metal absorption and could also be co-administered during chelation therapy to maintain essential metal status during chelation treatment and could serve a dual purpose; i) to prevent possible essential metal deficiency syndrome and ii) to accelerate lead elimination due to their own antagonistic/biochemical/pharmacological effects 128,163) .…”

Section: Coppermentioning

confidence: 99%

Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead Poisoning

Kalia¹,

Flora²

2005

Journal of Occupational Health

269

161

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Strategies for Safe and Effective Therapeutic Measures for Arsenic and LeadPoisoning: Kiran Kalia, et al. Department of Biosciences, Sardar Patel University, IndiaExposure to toxic metals remains a widespread occupational and environmental problem in world. There have been a number of reports in the recent past suggesting an incidence of childhood lead poisoning and chronic arsenic poisoning due to contaminated drinking water in many areas of West Bengal in India and Bangladesh has become a national calamity. Low level metal exposure in humans is caused by air, food and water intake. Lead and arsenic generally interferes with a number of body functions such as the central nervous system (CNS), the haematopoietic system, liver and kidneys. Over the past few decades there has been growing awareness and concern that the toxic biochemical and functional effects are occurring at a lower level of metal exposure than those that produce overt clinical and pathological signs and symptoms. Despite many years of research, we are still far from an effective treatment of chronic plumbism and arsenicosis. Medical treatment of acute and chronic lead and arsenic toxicity is furnished by chelating agents. Chelating agents are organic compounds capable of linking together metal ions to form complex ring-like structures called chelates. They have been used clinically as antidotes for acute and chronic poisoning. 2, 3-dimercaprol (BAL) has long been the mainstay of chelation therapy for lead or arsenic poisoning. Meso 2, 3, -dimercaptosuccinic acid (DMSA) has been tried successfully in animals as well as in a few cases of human lead and arsenic poisoning. DMSA could be a safe and effective method for treating lead or arsenic poisoning, but one of the major disadvantages of chelation with DMSA has been its Review inability to remove lead from the intracellular sites because of its lipophobic nature. Further, it does not provide protection in terms of clinical/ biochemical recovery. A new trend in chelation therapy is to use combined treatment. This includes the use of structurally different chelators or a combination of an adjuvant and a chelator to provide better clinical/ biochemical recovery in addition to lead mobilization. The present review article attempts to provide update information about the current strategies being adopted for a safe, effective and specific treatment for two major toxic metals or metalloid.

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“…Infants have a relatively high retention as compared to adults [7]. Indications have been found that lead interferes with the metabolism of calcium [8][9][10][11][12][13][14][15][16], magnesium [17], strontium [9], copper [1,18], iron [18,19]…”

mentioning

confidence: 99%

Lattice parameters and cation distribution of solid solutions of calcium and lead hydroxyapatite

Verbeeck

Lassuyt

Heijligers³

et al. 1981

Calcif Tissue Int

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Summary. Solid solutions of calcium hydroxyapatite (CaOHA) and lead hydroxyapatite (PbOHA) of the formula Ca,0.x Pbx (PO4)6 (OH)2 were prepared by coprecipitation followed by heating at 800~ in a stream of CO2-free water vapor of 1 atm. The samples were apatitic in the range 0 < x < 6 and contained lead phosphates as a second phase at higher Pb/Ca ratios. Lattice parameters and cation distribution of the apatitic samples were determined by X-ray diffraction. The lattice parameters varied linearly with x in the range considered, whereas all Pb 2+ were located in the sixfold position for cations. There was a miscibility gap in the apatite series of solid solutions in the range 1 < x < 4, whereas apatites in the range 6 < x < 10 were not stable under the conditions of preparation. It is concluded that apatites in the range 4 < x < 6 represent a minimum in the free energy of solid solutions between CaOHA and PbOHA.

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Protective value of dietary copper and iron against some toxic effects of lead in rats.

Cited by 66 publications

References 11 publications

Influence of nutrient intake on blood lead levels of young children at risk for lead poisoning.

Influence of nutrient intake on blood lead levels of young children at risk for lead poisoning.

Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead Poisoning

Lattice parameters and cation distribution of solid solutions of calcium and lead hydroxyapatite

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