Protein Adsorption on Polymers

Eberhart, Robert C.; Lynch, Michael; Bilge, Fertac H.; Wissinger, John F.; Munro, M. S.; Ellsworth, Stephen R.; Quattrone, Alfred J.

doi:10.1021/ba-1982-0199.ch021

Cited by 10 publications

(2 citation statements)

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“…Polyurethanes based on hydrophobic polyethylene oxide, adsorb albumin faster than those prepared with hydorphobic polypropylene oxide [142]. Albumin adsorption was enhanced by derivatization of the surface of polyurethanes with alkyl groups [144,145].…”

Section: Polymer Surface Modification and Blood Compatibilitymentioning

confidence: 99%

Selected topics in biomedical polyurethanes. A review

Gogolewski

1989

Colloid & Polymer Sci

224

140

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Section: Polymer Surface Modification and Blood Compatibilitymentioning

confidence: 99%

Selected topics in biomedical polyurethanes. A review

Gogolewski

1989

Colloid & Polymer Sci

224

140

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“…According to the studies of Hlady et al (1986), Rudee & Price (1 983, Brynda et al (1984) and Eberhart (1982) on protein adsorption on solid surfaces, the above mentioned differences must be extended to take into account (i) differences in the amount of adsorbed molecules, and (ii) differences in the coverage, i.e. either the presence of a continuous film or a patchwork pattern.…”

Section: H P R a T T -T E R P S T R A A N D Othersmentioning

confidence: 99%

Adhesion of Oral Streptococci from a Flowing Suspension to Uncoated and Albumin-coated Surfaces

Pratt-Terpstra

Weerkamp²,

Busscher³

1987

Microbiology

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A flow cell system was developed which allowed the study of bacterial adhesion to solid substrata at well-defined shear rates. In addition, the system enabled the solid surfaces to be coated with a proteinaceous film under exactly the same shear conditions. In this flow cell system, adhesion of three strains of oral streptococci from a phosphate-buffered solution onto three different substrata was studied as a function of time in the absence and presence of a bovine serum albumin (BSA) coating at a shear rate of 21 s-'. To obtain a wide range in surface free energies (y) representative strains (Yb 38-1 17 mJ m-2) and solid substrata (y, 20-109 mJ m-') were selected. The number of bacteria adhering was counted microscopically. In the absence of a BSA coating a linear relation was found between the number of bacteria adhering at saturation (nb.,) and the calculated interfacial free energy of adhesion (AFadh) for each of the three strains. In the presence of a BSA coating the number of bacteria adhering was greatly decreased in all cases. However, despite the presence of the BSA coating there was still a linear relation between the number of bacteria adhering at saturation and the interfacial free energy of adhesion, calculated on the basis of the surface free energy of the uncoated substrata. It can be concluded that the bare, uncoated substratum still influenced bacterial adhesion in spite of the marked influence of a BSA coating.

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The initial stages of adsorption of plasma derived proteins on artificial surfaces in a controlled flow environment

Rudee

Price

1985

J. Biomed. Mater. Res.

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Surfaces of amorphous carbon, polystyrene, and polycarbonate were exposed to solutions of fibrinogen, a modified fibrinogen which lacked the alpha chain protuberance, and serum albumin. The results were studied by electron microscopy. The exposures occurred in a well characterized flow environment at a shear rate of 135/s. All three protein species formed a film when adsorbed to carbon films. When the proteins were adsorbed to polystyrene surfaces, formation of a network was observed. Polycarbonate surfaces adsorbed the proteins both as a network and as a continuous film. It was observed that the nature of the adsorption process depended upon the specific combination of molecule and material. For example, on carbon, individual fibrinogen molecules retain their trinodular structure and adsorb randomly until a monolayer forms. On polystyrene, the individual fibrinogen molecules appear as globules and a network forms before complete coverage occurs.

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Protein Adsorption on Polymers

Cited by 10 publications

References 0 publications

Selected topics in biomedical polyurethanes. A review

Selected topics in biomedical polyurethanes. A review

Adhesion of Oral Streptococci from a Flowing Suspension to Uncoated and Albumin-coated Surfaces

The initial stages of adsorption of plasma derived proteins on artificial surfaces in a controlled flow environment

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