2020
DOI: 10.1002/open.202000025
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Protein Assays on Organic Electronics: Rational Device and Material Designs for Organic Transistor‐Based Sensors

Abstract: Artificial receptor-based protein assays have various attractive features such as a long-term stability, a low-cost production process, and the ease of tuning the target specificity. However, such protein sensors are still immature compared with conventional immunoassays. To enhance the application potential of synthetic sensing materials, organic field-effect transistors (OFETs) are some of the suitable platforms for protein assays because of their solution processability, durability, and compact integration.… Show more

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Cited by 7 publications
(7 citation statements)
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“…(1) The chemical and thermal stabilities of the molecular recognition materials on the OFET need to be improved. In this regard, we have recently developed artificial molecular recognition materials for the detection of phosphoprotein, (27,65) serum albumin, (27,66) and lactate. (67) Because these artificial materials have greater stability than natural materials, artificial materials for psychological stress markers also need to be developed toward future applications.…”
Section: Discussionmentioning
confidence: 99%
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“…(1) The chemical and thermal stabilities of the molecular recognition materials on the OFET need to be improved. In this regard, we have recently developed artificial molecular recognition materials for the detection of phosphoprotein, (27,65) serum albumin, (27,66) and lactate. (67) Because these artificial materials have greater stability than natural materials, artificial materials for psychological stress markers also need to be developed toward future applications.…”
Section: Discussionmentioning
confidence: 99%
“…By employing a floating-gate electrode structure, the electrical properties of the OFET vary upon the addition of an analyte on the extended gate. (26,27) The changes in the electrical characteristics of the OFET stemming from the molecular recognition phenomena can be quantified using Eq. (1): (33)…”
Section: Extended-gate-type Ofets As Sensing Platform For Biomarkersmentioning
confidence: 99%
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“…Therefore, this standpoint from molecular recognition chemistry is important to achieve the accurate quantitative determination of biomarkers by using OTFTs. Toward this end, molecular recognition researchers have already established a strategy for achieving these requirements of protein detection [11][12][13] ; nevertheless, suitable materials and functionalization for wearable sensors for the detection of proteins have not been considered in the field of device engineering. In this regard, although we have carefully examined the protein sensing ability of OTFT devices functionalized with several sensing materials 14 , further consideration of flexible and printed OTFTs for protein determination is required.…”
mentioning
confidence: 99%