Protein–based electrospun nanofibers: electrospinning conditions, biomedical applications, prospects, and challenges

Uddin, Md Nur; Jobaer, Md.; Mahedi, Sajjatl Islam; Ali, Ayub

doi:10.1080/00405000.2022.2135479

Cited by 12 publications

(6 citation statements)

References 279 publications

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“…Gelatin, derived from collagen by hydrolysis, is found in animal skin, ligaments, cartilage, and bone [170]. The ability of gelatin fibers to mimic the extracellular matrix (ECM) structure of human tissues, coupled with their excellent biocompatibility, biodegradability, and widespread commercial availability, makes them suitable for a range of applications.…”

Section: Gelatinmentioning

confidence: 99%

“…The ability of gelatin fibers to mimic the extracellular matrix (ECM) structure of human tissues, coupled with their excellent biocompatibility, biodegradability, and widespread commercial availability, makes them suitable for a range of applications. These include drug delivery and tissue engineering [170,171]. Gelatin, being soluble in water, faces challenges in electrospinning due to substantial hydrogen bonding [170].…”

Section: Gelatinmentioning

confidence: 99%

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Electrospinning: Processes, Structures, and Materials

Ahmadi Bonakdar,

Rodrigue

2024

Macromol

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Electrospinning is a simple and affordable method of producing nanofibers, offering a large specific surface area and highly porous structures with diameters ranging from nanometers to micrometers. This process relies on an electrostatic field, providing precise control over the fiber dimensions and morphologies through parameter optimization and the use of specialized spinnerets and collectors. The paper extensively covers the electrospinning process and parameters, shedding light on the factors influencing electrospinning. It addresses the morphological and structural aspects of electrospun fibers that are used in different applications. Additionally, this paper explores various polymeric and non-polymeric materials used in electrospinning. Furthermore, it investigates the incorporation of fillers during electrospinning, using an electric field to enhance properties and functionality. The review concludes by offering insights into upscaling electrospinning production.

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Section: Gelatinmentioning

confidence: 99%

Section: Gelatinmentioning

confidence: 99%

Electrospinning: Processes, Structures, and Materials

Ahmadi Bonakdar,

Rodrigue

2024

Macromol

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“…Polymers 2023, 15, x FOR PEER REVIEW 3 of 23 [14,15]. The large majority of research we report here has been published within the past five years.…”

Section: Introductionmentioning

confidence: 99%

“…With attention given to the biomedical utilization, the technical aspect of the material production through electrospinning is slightly out of focus in this review. To our knowledge, the papers on similar topic are either less oriented to solely vegetal proteins, or they cover less recent studies [ 14 , 15 ]. The large majority of research we report here has been published within the past five years.…”

Section: Introductionmentioning

confidence: 99%

Agro-Industrial Plant Proteins in Electrospun Materials for Biomedical Application

et al. 2023

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Plant proteins are receiving a lot of attention due to their abundance in nature, customizable properties, biodegradability, biocompatibility, and bioactivity. As a result of global sustainability concerns, the availability of novel plant protein sources is rapidly growing, while the extensively studied ones are derived from byproducts of major agro-industrial crops. Owing to their beneficial properties, a significant effort is being made to investigate plant proteins’ application in biomedicine, such as making fibrous materials for wound healing, controlled drug release, and tissue regeneration. Electrospinning technology is a versatile platform for creating nanofibrous materials fabricated from biopolymers that can be modified and functionalized for various purposes. This review focuses on recent advancements and promising directions for further research of an electrospun plant protein-based system. The article highlights examples of zein, soy, and wheat proteins to illustrate their electrospinning feasibility and biomedical potential. Similar assessments with proteins from less-represented plant sources, such as canola, pea, taro, and amaranth, are also described.

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“…[ 10 ] Since the enzymes essentially present in the body can metabolize these proteins into absorbable benign amino acids, BSA‐based nano‐appliances can be used in the biomedical and pharmaceutical fields. [ 11 ] Multiple nano‐appliance have been developed in the form of films, membranes, sponge‐like material, hydrogels, particles, or fibers. With their homology with ECM, nano‐fibers (NFs) successfully manifested unlimited applications from wound dressings to localized drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Electrospinning of bovine serum albumin‐based nano‐fibers: From synthesis to medical prospects; Challenges and future directions

Hayat,

Bukhari,

Irfan

2023

Biotechnology Journal

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Bovine serum albumin (BSA) is a globular non‐glycoprotein that has gotten a lot of attention because of its unique properties like biocompatibility, biodegradability, non‐immunogenicity, non‐toxicity, and strong resemblance to the natural extracellular matrix (ECM). Given its robust mechanical properties, such as interfacial tension, conductivity, swelling resistance, and viscoelasticity, it can be concluded that it is an appropriate matrix for producing novel BSA‐based nanoconstructs. Thus, simple analytic methods are required for accurately detecting BSA as a model protein in medical sciences and healthcare. Furthermore, the characteristics mentioned above aid BSA in the electrospinning process, which results in fibres conjugated with other polymers. Electrospun synthesis has recently received much attention for its ability to produce stable, biomimicking, highly porous, 3D BSA‐derived nano‐fibers. As a result, BSA‐based nano‐fibers have achieved exclusive developments in the medical sector, such as tissue engineering for the remodelling of damaged tissue or organ repair by creating artificial ones.Meanwhile, they could be used as drug delivery systems for target‐specific drug delivery, wound dressings, etc. This study illustrates the structural and physicochemical properties of BSA and the determination of BSA using various methods, by citing recent reports and current developments in the medical field. Furthermore, current challenges and future directions are also highlighted.This article is protected by copyright. All rights reserved

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Protein–based electrospun nanofibers: electrospinning conditions, biomedical applications, prospects, and challenges

Cited by 12 publications

References 279 publications

Electrospinning: Processes, Structures, and Materials

Electrospinning: Processes, Structures, and Materials

Agro-Industrial Plant Proteins in Electrospun Materials for Biomedical Application

Electrospinning of bovine serum albumin‐based nano‐fibers: From synthesis to medical prospects; Challenges and future directions

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