Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis

Kanosue, Kiyoko; Nagaya, Satomi; Morishita, Eriko; Yamanishi, M.; Imashuku, Shinsaku

doi:10.1055/s-0041-1728664

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…Clostridia (especially Clostridium di cile and Clostridium perfringens) were found to be associated with thrombotic events such as VTE, portal vein thrombosis, superior mesenteric vein thrombus, and visceral vein thrombosis [44][45][46][47][48]. Additionally, in vitro and animal studies have indicated that platelet endothelial cell adhesion molecule-1 (PECAM-1) plays a negative regulatory role in thrombus formation [49,50], while the binding of Clostridium perfringens βtoxin to PECAM-1 induces the formation of cellular membrane pores, thereby interfering with the function of PECAM-1 [51].…”

Section: Discussionmentioning

confidence: 99%

Systematic Mendelian randomization study of the effect of gut microbiome and plasma metabolome on venous thromboembolism

Cheng,

He,

et al. 2023

Preprint

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Background Although there is considerable evidence suggesting a link between gut microbiota (GM) composition and venous thromboembolism (VTE)/deep vein thrombosis (DVT)/pulmonary embolism (PE), population-level studies that can establish a causal relationship are currently lacking. Methods Using two-sample Mendelian randomization (MR) approach was used to examine the causal effects of 211 GM and 489 plasma metabolites on VTE/PE/DVT. We employed instrumental variables comprised of single nucleotide polymorphisms (SNPs) strongly associated with GM composition and plasma metabolite levels to determine whether these factors play a causal role in the development of VTE/DVT/PE. Additionally, we conducted mediation analysis to explore the potential associations between specific taxonomic groups and metabolites. Results The MR analysis revealed significant associations between 16 taxonomic units and 40 metabolites with VTE/DVT/PE as the causative factors. Among these, Firmicutes, Clostridia, Roseburia, Ruminococcaceae NK4A214, and Intestinimonas were found to have a protective effect against VTE/DVT/PE. In contrast, Bacteroidetes, Anaerotruncus, Victivallales, Desulfovibrionaceae, Clostridium innocuum, Eubacterium oxidoreducens, and Lachnoclostridium have been identified as risk factors for VTE/DVT/PE. Reverse MR analysis revealed 11 associations between VTE/DVT/PE and GM. Furthermore, no significant heterogeneity or horizontal pleiotropy was observed in any of the instrumental variables. Mediation analysis revealed 10 intermediate relationships, and metabolic pathway analysis identified 6 significant pathways. Conclusions Our study emphasizes the significant causal associations between the gut microbiota (GM), plasma metabolome, and VTE/DVT/PE. These interconnections have the potential to be used as clinical biomarkers for risk stratification and prognosis assessment in patients with VTE/DVT/PE.

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