Protein Carbonyls in Decidua and Placenta of Pre-eclamptic Women as Markers for Oxidative Stress

Zusterzeel, Petra L.M.; Rütten, Heidi; Roelofs, Hennie M.J.; Peters, Wilbert H.M.; Steegers, Eric A.P.

doi:10.1053/plac.2000.0606

Cited by 126 publications

(70 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Zusterzeel et al demonstrated increased plasma and placenta protein carbonyl levels in preeclamptic women. 9,10 We also noted a significant correlation between plasma carbonyl levels, but not plasma TBARS levels, and blood pressure. Free radical generation may induce the activation of maternal neutrophils.…”

Section: Discussionmentioning

confidence: 55%

“…12 We could not find significant differences between preeclamptic patients and normal gestation in the plasma levels of the prototype anti-inflammatory cytokine IL-10, but other studies demonstrated a decrease in IL-10 levels in preeclamptic gestation. 9,10 In addition, it is possible that oxidative stress and inflammatory response could be related to endothelial dysfunction, and this could explain the relation between these markers and hypertension. In fact, it was demonstrated that endothelial damage occurs in preeclampsia and it seems to be correlated to inflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia

Bernardi

Guolo

Bortolin

et al. 2008

J of Obstet and Gynaecol

View full text Add to dashboard Cite

Aim: Although previous investigators have demonstrated the presence of oxidative stress and inflammation in preeclampsia, none directly correlate both to preeclampsia. Methods: We determined in 35 preeclamptic and 35 normotensive pregnant women plasma levels of thiobarbituric acid reactive species, protein carbonyl, tumour necrosis factor-a (TNF-a), interleukin-1b (IL-1b), IL-6 and IL-10. Results: Plasma thiobarbituric acid reactive species and protein carbonyls were higher in preeclamptic patients. TNF-a and IL-6 (but not IL-1b or IL-10) were higher in preeclamptic patients. We found significant correlation between plasma IL-6 and carbonyls, and these correlated to blood pressure. Conclusions: We demonstrated that some oxidative and inflammatory mediators were altered in preeclampsia, and some correlated to blood pressure.

show abstract

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia

Bernardi

Guolo

Bortolin

et al. 2008

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…78 This has raised the question as to the relevance of increases of these materials to oxidative stress in preeclampsia. Nonetheless, there is abundant other evidence for oxidative stress in preeclampsia, including protein products of oxidative stress in maternal 79 and fetal tissues 80 as well as antibodies to oxidatively modified LDL. 81 Furthermore, concentrations of the lynchpin antioxidant ascorbate are reduced in women with preeclampsia and women destined to develop preeclampsia.…”

Section: The Linkage Of Stages 1 Andmentioning

confidence: 99%

Preeclampsia

2005

View full text Add to dashboard Cite

Abstract-Preeclampsia is a pregnancy complication with serious consequences for mother and infant. The disorder is diagnosed by gestational hypertension and proteinuria but is far more than pregnancy induced hypertension. Preeclampsia is proposed to occur in 2 stages. Key Words: preeclampsia Ⅲ hypertension, pregnancy Ⅲ oxidative stress Ⅲ endothelium P reeclampsia is a pregnancy complication recognized by new-onset gestational hypertension and proteinuria (see definitions below). The disorder affects both mothers and their infants. Once the disease is evident clinically, it can be cured only by delivery. In developed countries, surveillance for preeclampsia through prenatal care allows for early identification and intervention via delivery. This management has changed little in the last 100 years, and it is very effective at reducing maternal mortality. However, maternal morbidity remains great with preeclampsia, which continues to be one of the leading causes for the admission of pregnant women to intensive care units in the developed world. 1 Furthermore, fetal mortality and morbidity is considerable, related to the effects of the disease on the fetus as well as prematurity. The indicated delivery of women to prevent the progression of preeclampsia is responsible for 15% of all preterm births. 2 In developing countries, where inadequate prenatal care limits preeclampsia surveillance, maternal mortality is common, accounting for 50 000 deaths yearly. 3 The hypertensive disorders of pregnancy include hypertension that antedates pregnancy, chronic hypertension, and gestational hypertension occurring uniquely during pregnancy. When the gestational hypertension is accompanied by new-onset proteinuria, the disorder is termed preeclampsia, and when not associated with proteinuria, transient hypertension of pregnancy. If the woman with chronic hypertension also manifests evidence of preeclampsia, this is classified chronic hypertension with superimposed preeclampsia. Eclampsia is the occurrence of seizures in women with preeclampsia. 4 These criteria have been extraordinarily useful to aid in recognizing pregnant women at risk. Greatest risk for mother and baby is present with preeclampsia, and the risk for chronic hypertensive pregnancy is primarily with superimposed preeclampsia. However, the attention to hypertension has, for many years, limited research attention to primarily mechanisms of hypertension. This has not been helpful. In the last 2 decades, appreciation that preeclampsia is a multisystemic syndrome characterized by vasoconstriction, metabolic changes, endothelial dysfunction, activation of the coagulation cascade, and increased inflammatory response, to mention only some of the organ systems involved, has redirected research. 5 As a result, progress in understanding the disorder has accelerated greatly, with attendant optimism for potentially effective treatments. 5 In this article, we consider this recent progress and its clinical implications.

show abstract

“…Lipid oxidation products 38 Antibodies to oxidized LDL 62 In systemic maternal tissues Increased nitrotyrosine residues in blood vessels 65 Activated neutrophils and monocytes 66 In decidua Atherosis with lipid-laden macrophages 20 Increased lipid peroxides 67 Increased isoprostanes (8 iso PGF2␣) 68 Protein carbonyls 69 In placenta…”

Section: Lipid Markersmentioning

confidence: 99%

“…Reduced superoxide dismutase 70,72 Reduced glutathione peroxidase 73 Lipid markers Increased malondialdehyde 74 Increased lipid peroxides 73 Protein carbonyls 69 and neutrophils or monocytes activated directly in the intervillous space or by material (placental fragments or cytokines) from the hypoxic placenta. Furthermore, the identification of angiotensin antibodies with the capability to activate NADPH oxidase with subsequent free radical formation in women with preeclampsia suggests a very different origin for oxidative stress.…”

Section: Antioxidantsmentioning

confidence: 99%

Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy

et al. 2003

View full text Add to dashboard Cite

Abstract-A Working Group on Research in Hypertension in Pregnancy was recently convened by the National Heart, Lung, and Blood Institute to determine the state of knowledge in this area and suggest appropriate directions for research. Hypertensive disorders in pregnancy, especially preeclampsia, are a leading cause of maternal death worldwide and even in developed countries increase perinatal mortality rates 5-fold. Much has been learned about preeclampsia, but gaps in the knowledge necessary to direct therapeutic strategies remain. Oxidative stress is a biologically plausible contributor to the disorder that may be amenable to intervention. Hypertension that antedates pregnancy (chronic hypertension) bears many similarities to hypertension in nonpregnant women, but the special setting of pregnancy demands information to guide evidence-based therapy. The recommendations of the Working Group are to attempt a clinical trial of antioxidant therapy to prevent preeclampsia that is be complemented by mechanistic research to increase understanding of the genetics and pathogenesis of the disorder. For chronic hypertension, clinical trials are recommended to direct choice of drugs, evaluate degree of control, and assess implications to the mother and fetus.Recommendations to increase participation in this research are also presented.

show abstract

Protein Carbonyls in Decidua and Placenta of Pre-eclamptic Women as Markers for Oxidative Stress

Cited by 126 publications

References 30 publications

Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia

Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia

Preeclampsia

Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy

Contact Info

Product

Resources

About