Protein CRABP1 as one of the possible prognosis factors in children with high-risk neuroblastoma

Строганова, А. М.; Рубанская, М. В.; Чемерис, Г. Ю.; Дранко, С. Л.; Карселадзе, А. И.; Сагоян, Г. Б.; Казанцев, А. П.

doi:10.21682/2311-1267-2019-6-4-48-54

Ross. ž. det. gematol. onkol.

2020

DOI: 10.21682/2311-1267-2019-6-4-48-54

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Protein CRABP1 as one of the possible prognosis factors in children with high-risk neuroblastoma

А. М. Строганова¹,

М. В. Рубанская²,

Г. Ю. Чемерис³

et al.

Abstract: Российский журнал ДЕТСКОЙ ГЕМАТОЛОГИИ и ОНКОЛОГИИ R u s s i a n J o u r n a l o f P e d i a t r i c H e m a t o l o g y а n d O n c o l o g y 48 О р и г и н а л ь н ы е и с с л е д о в а н и я || O r i g i n a l s t u d i e s

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Cited by 2 publications

References 26 publications

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Molecular genetic traits and risk factors for neuroblastoma

Klimenko,

Melnikov,

Kulyova

et al. 2023

Pediatr (SPb)

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Neuroblastoma is the most common extracranial solid tumor in childhood, accounting for 815% of all malignant neoplasms in children. The uniqueness of the neuroblastoma etiology and pathogenesis creates significant difficulties for doctors due to the unpredictability of the course of the disease: the tumor can regress and lead to death in a short time, showing significant immunity to ongoing therapy. Early diagnosis of a tumor is necessary to understand the risk factors, the etiology, the mechanisms of neuroblastoma occurrence and further development. To date, a number of different risk factors have been identified, related both to genetic aspects and to aspects related to the course of pregnancy, birth and lifestyle of the childs parents. The list of these risk factors is still incomplete and research to identify new factors continues to this day. Morphological and molecular genetic diagnostics play an important role in this. Undifferentiated and low-differentiated variants of neuroblastoma are often associated with MYCN amplification and other chromosomal aberrations determined by molecular genetic research. Chromosomal instability plays an important role in the process of early tumor development, which probably causes the possibility of acquiring certain genetic changes, which also determines the prognosis and further therapeutic options. In this article, we have identified the most significant risk factors by comparing the results of various studies.

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Molecular genetic traits and risk factors for neuroblastoma

Klimenko,

Melnikov,

Kulyova

et al. 2023

Pediatr (SPb)

View full text Add to dashboard Cite

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Surgical treatment of retroperitoneal neuroblastoma in a 14-month-old child

Сухов

Narbutov

Лывина

et al. 2021

Russian Journal of Pediatric Surgery

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Introduction. Neuroblastoma is the most common malignant embryonic extracranial solid tumor in childhood having a high mortality rate. While treating neuroblastoma, it is extremely important to follow international protocols with their staging systems and groups of risk. Surgical treatment is a compulsory approach, but in some cases it is extremely difficult, and it involves significant risks. However, in some cases, radical removal of the tumor can cure patients without chemotherapy.Material and methods. The article presents a clinical case of 14-month-old child with neuroblastoma of stage 3 and difficult anatomical location after 2 courses of polychemotherapy by NB-2004 protocol. The child had subradical resection of an extensive tumor in the retroperitoneal space and nephrectomy on the right. The authors also describe specific moments during surgery, problems which their faced during child’s treatment as well as follow-up examinations in the postoperative period.Results. Follow-up examinations did not reveal any signs of disease recurrence. Catamnesis lasted for 56 months. The child is in a good state; she is active, attends a nursery school.Conclusion. The discussed case demonstrates that a successful radical surgical removal of neuroblastoma of difficult anatomic location may have good outcomes without adjuvant postoperative therapy.

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Protein CRABP1 as one of the possible prognosis factors in children with high-risk neuroblastoma

Cited by 2 publications

References 26 publications

Molecular genetic traits and risk factors for neuroblastoma

Molecular genetic traits and risk factors for neuroblastoma

Surgical treatment of retroperitoneal neuroblastoma in a 14-month-old child

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