Protein digestibility of porcine colostrum by neonatal pigs

Lin, C. C. Sheree; Mahan, D. C.; Wu, Guoyao; Kim, Sung Woo

doi:10.1016/j.livsci.2008.06.006

Cited by 25 publications

(12 citation statements)

References 35 publications

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“…Differential proteomes in milk from mammary glands centrations of IgA and IgM. Lin et al (2009) demonstrated that neonatal piglets can absorb 25% of IgG from colostrum. In contrast, IgA is the predominant protein in mature milk of the sow (Sangild et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Differential composition of proteomes in sow colostrum and milk from anterior and posterior mammary glands1

Wang

et al. 2010

Journal of Animal Science

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Piglets obtaining milk from anterior and middle mammary glands (MG) grow faster than those suckling posterior MG, but the underlying mechanisms are not clear. The purpose of this study was to investigate the differential proteomes of colostrum and milk secreted by anterior and posterior MG. Six healthy primiparous sows with 7 pairs of MG were used; the first and the second pairs were defined as anterior MG and the sixth and seventh pairs as posterior MG. Colostrum and milk were collected at d 1 and 14 after parturition, respectively. Comparative proteomics analysis was performed to identify the differentially expressed proteins in colostrum and milk secreted by anterior and posterior MG. Results show that protein composition in colostrum and milk varied markedly with the anatomical location of MG. Immunoglobulins, lactadherin, and haptoglobin were upregulated (P < 0.05) in colostrum from anterior MG compared with posterior MG. Concentrations of immunoglobulins and lactoferrin in milk from anterior MG were greater (P < 0.05) than milk from posterior MG. Moreover, concentration of proteins from somatic cells was greater (P < 0.05) in milk from posterior MG compared with anterior MG. Most proteins, in which abundance was upregulated in colostrum and milk from anterior MG, contribute to passive immunity, intestinal development of suckling piglets and epithelial integrity, and the health of MG. Collectively, these results indicate that in comparison with posterior MG, anterior MG are more active in protein synthesis and produce more immunoglobulins and lactoferrin in colostrum and milk.

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Section: Discussionmentioning

confidence: 99%

Differential composition of proteomes in sow colostrum and milk from anterior and posterior mammary glands1

Wang

et al. 2010

Journal of Animal Science

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“…The nutritional importance of colostrum for the survival and body growth of newborn pigs is e.g. indicated by the high digestibility of proteins in porcine colostrum of up to 100% (Lin et al 2009). Jensen et al (2001) demonstrated a considerable uptake of bovine macromolecules from cow's colostrum in newborn piglets during the first 12 h after birth (Jensen et al 2001).…”

Section: Doi: 1017221/8404-cjasmentioning

confidence: 99%

Effects of bovine colostrum on performance, survival, and immunoglobulin status of suckling piglets during the first days of life

Viehmann¹,

Unterweger²,

Ganter³

et al. 2015

Czech J. Anim. Sci.

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Supplementation of bovine colostrum (BC) has shown to improve growth performance, intestinal development, and immune response in early-weaned pigs. Little is known about whether BC may have similar effects in neonatal piglets. In the present study, the effect of BC supplementation on mortality, growth performance, and blood parameters (plasma proteins and white blood count) of suckling piglets in the first 10 days of life was investigated under practical conditions with special emphasis on low birth weight piglets. In total, 258 newborn piglets from 30 multiparous sows in a commercial breeding unit were randomly assigned to two different treatment groups. Piglets received either 1 ml of BC orally on days 1-3 of life (group BC, n = 128) or 1 ml of saline (0.9%) (control (CON) group; n = 130). Body weight was measured on days 1, 4, and 10 of life. Blood was collected on days 1 and 4 from 60 piglets per group. No differences in mortality, body weight, and average daily weight gain were observed between treatment groups in days 1-10. However, compared to CON, particularly in low birth weight piglets the administration of BC supported (P < 0.01) their survival. Group BC exhibited lower plasma total protein (P = 0.03) and beta-globulin (P = 0.02) concentrations compared to group CON. In conclusion, BC improved low and normal birth weight piglets' survival during their first 10 days of life. Further research is needed to clarify whether the survival rate is related to earlier gut closure indicated by lower plasma protein levels, which might be beneficial due to a lower uptake of potential antigenic substances.

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“…Therefore, pigs are an accepted and extensively used model for specific types of nutritional studies (Moughan and Rowan, 1989;Spurlock and Gabler, 2008). For example, pigs have been used to study protein digestion in human infants (Darragh and Moughan, 1995;Lin et al, 2009); digestibility of dietary amino acids (Rowan et al, 1994;Wu, 1998;Reeds and Burrin, 2000) and the effect of infant milk formulas on organ development and digestive enzyme activities (Moughan et al, 1990 and. A review of the pig as an experimental model for elucidating the mechanisms governing dietary influence on mineral absorption has recently been published by Patterson et al (2008), and so this aspect of digestion will not be considered herein.…”

Section: Digestive Physiology and Metabolismmentioning

confidence: 99%

Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview

Litten-Brown

Corson

Clarke

2010

Animal

147

136

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The aim of this review article is to provide an overview of the role of pigs as a biomedical model for humans. The usefulness and limitations of porcine models have been discussed in terms of metabolic, cardiovascular, digestive and bone diseases in humans. Domestic pigs and minipigs are the main categories of pigs used as biomedical models. One drawback of minipigs is that they are in short supply and expensive compared with domestic pigs, which in contrast cost more to house, feed and medicate. Different porcine breeds show different responses to the induction of specific diseases. For example, ossabaw minipigs provide a better model than Yucatan for the metabolic syndrome as they exhibit obesity, insulin resistance and hypertension, all of which are absent in the Yucatan. Similar metabolic/physiological differences exist between domestic breeds (e.g. Meishan v. Pietrain). The modern commercial (e.g. Large White) domestic pig has been the preferred model for developmental programming due to the 2-to 3-fold variation in body weight among littermates providing a natural form of foetal growth retardation not observed in ancient (e.g. Meishan) domestic breeds. Pigs have been increasingly used to study chronic ischaemia, therapeutic angiogenesis, hypertrophic cardiomyopathy and abdominal aortic aneurysm as their coronary anatomy and physiology are similar to humans. Type 1 and II diabetes can be induced in swine using dietary regimes and/or administration of streptozotocin. Pigs are a good and extensively used model for specific nutritional studies as their protein and lipid metabolism is comparable with humans, although pigs are not as sensitive to protein restriction as rodents. Neonatal and weanling pigs have been used to examine the pathophysiology and prevention/treatment of microbial-associated diseases and immune system disorders. A porcine model mimicking various degrees of prematurity in infants receiving total parenteral nutrition has been established to investigate gut development, amino acid metabolism and non-alcoholic fatty liver disease. Endoscopic therapeutic methods for upper gastrointestinal tract bleeding are being developed. Bone remodelling cycle in pigs is histologically more similar to humans than that of rats or mice, and is used to examine the relationship between menopause and osteoporosis. Work has also been conducted on dental implants in pigs to consider loading; however with caution as porcine bone remodels slightly faster than human bone. We conclude that pigs are a valuable translational model to bridge the gap between classical rodent models and humans in developing new therapies to aid human health.

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Protein digestibility of porcine colostrum by neonatal pigs

Cited by 25 publications

References 35 publications

Differential composition of proteomes in sow colostrum and milk from anterior and posterior mammary glands1

Differential composition of proteomes in sow colostrum and milk from anterior and posterior mammary glands1

Effects of bovine colostrum on performance, survival, and immunoglobulin status of suckling piglets during the first days of life

Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview

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