Protein Drug Manufacturing

Lanfear, Denny; Hassler, Randy; Sitney, Karen; Curless, Craig; Patro, S. K.; Tsai, Larry B.; Ogez, John R.

doi:10.1007/978-1-59259-705-5_11

Cited by 1 publication

(2 citation statements)

References 90 publications

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“…87 In the biotech industry process streams may be pumped past sonic horns to disrupt cells and facilitate product isolation. 88 In the simplest laboratory applications, scale-up is limited by the concentration of the reactants and by the size of the reactor that fits into an ultrasonic bath. 89 Further scale-up can be carried out in commercially available continuous-flow reactors.…”

Section: Continuous Processing That Has Been Applied To Laboratory Op...mentioning

confidence: 99%

“…A continuous-flow apparatus has been claimed for blood hemolysis . In the biotech industry process streams may be pumped past sonic horns to disrupt cells and facilitate product isolation . In the simplest laboratory applications, scale-up is limited by the concentration of the reactants and by the size of the reactor that fits into an ultrasonic bath…”

Section: Continuous Processing That Has Been Applied To Laboratory Op...mentioning

confidence: 99%

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Practical Use of Continuous Processing in Developing and Scaling Up Laboratory Processes

Anderson

2001

Org. Process Res. Dev.

164

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Continuous operations can be used for the efficient scale-up of many processes that cannot be carried out through batch operations. Rapid reactions with reactive intermediates and products can be scaled up in the laboratory using continuously stirred tank reactors (CSTR) and plug flow reactors (PFR). Continuous processing in small reactors allows for better control of exothermic processing, creating a larger margin of safety for scale-up. This review also discusses the advantages of continuous processing for thermochemical rearrangements, immobilized catalysts, and microwave, photochemical, electrochemical, and sonochemical processes. Many of these continuous operations can be performed using equipment readily available for the laboratory, and can be readily scaled up in the laboratory and pilot plant.

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Section: Continuous Processing That Has Been Applied To Laboratory Op...mentioning

confidence: 99%

Section: Continuous Processing That Has Been Applied To Laboratory Op...mentioning

confidence: 99%

Practical Use of Continuous Processing in Developing and Scaling Up Laboratory Processes

Anderson

2001

Org. Process Res. Dev.

164

View full text Add to dashboard Cite

show abstract

Protein Drug Manufacturing

Cited by 1 publication

References 90 publications

Practical Use of Continuous Processing in Developing and Scaling Up Laboratory Processes

Practical Use of Continuous Processing in Developing and Scaling Up Laboratory Processes

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