Protein-losing enteropathy associated with gastrointestinal allergy

Evaluation of serum biochemical marker concentrations and survival time in dogs with protein-losing enteropathy

“…signs of varying severity, including PLE. [6][7][8][9][10] However, any disease causing gastrointestinal tract inflammation, infiltration, congestion, or bleeding can result in PLE. 11 Identifying gastrointestinal tract disease in a dog with hypoproteinemia and ruling out cutaneous protein loss, renal protein loss, and hepatic insufficiency lead to a diagnosis of PLE.…”

Epidemic Non-A Non-B Hepatitis in Urban Karachi, Pakistan

“…Accompanying allergic phenomena such as eczema, rhinitis and asthma pccur in upto 50% of patients. Treatment includes a trial of elimination diet which helps in a minority of patients 5 . Medications, which have been tried, include ketotifen, an eosinophilic degranulation preventing substance and sodium cromoglycate.…”

Co-existent eosinophilic gastroenteritis and hypothalamic-pituitary dysfunction

“…In the larger series of eosinophilic gastroenteritis reported to date, fewer than 50°o of patients have demonstrated reaction to foodstuffs (Edelman and March, 1964;Klein et al, 1970). Some authors have demonstrated accentuation of mucosal eosinophilia with severe clinical symptoms when implicated food was instilled into the jejunum of a patient with this disease (Greenberger, Tannenbaum and Ruppert, 1967;Klein et al, 1970). In contrast, Leinbach and Rubin (1970), in a blind review of intestinal biopsies taken during challenge with known precipitating foodstuffs, showed no significant changes either in villous architecture or in the degree of intestinal infiltration with eosinophils.…”

“…The presentation of the present case with diarrhoea, steatorrhoea and faecal blood loss is unusual and presumably reflects predominant mucosal disease. Protein-losing enteropathy and/or malabsorption have been increasingly described in cases with mucosal involvement (Bentlif et al, 1966;Greenberger et al, 1967;Waldmann et al, 1967;Scudamore et al, 1969;Kaplan et al, 1970;Leinbach and Rubin, 1970;Klein et al, 1970). Intestinal blood and protein loss might be explained by exudation through areas of surface epithelium compromised by massive underlying eosinophilic infiltration (Leinbach and Rubin, 1970).…”