Protein Loss across Burn Wounds

Waxman, Kenneth; Rebello, Tessio; Pinderski, Laura J.; O'neal, Kelly; Khan, Nassir; Tourangeau, Steve; Himes, Edward; Cordill, Kelly

doi:10.1097/00005373-198702000-00006

Cited by 70 publications

(39 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous results (8), not specifically addressing the early light phase, showed that after a single injection in a time period restricted essentially to the second half of darkness, a response to agonists (including TSO) occurred and was maximal at 2 h postinjection. We now show that the response to this ISO stimulus occurs in the early light phase.…”

Section: Discussionmentioning

confidence: 82%

“…Persistence of responsiveness after light-induced or spontaneous fall of EMS suggests that control of adrenergic responsiveness may not normally be exerted through sympathetic innervation to the pineal, which does control EMS. This notion is corroborated by onset of nocturnal responsiveness to norepinephrine even after superior cervical ganglionectomy (8), though this procedure does block the EMS surge (14).…”

Section: Discussionmentioning

confidence: 83%

“…However, ganglionectomy did not lead to supersensitivity (5,8), again suggesting that responsiveness itself may be independent of sympathetic input at the level of the pinealocyte.…”

Section: Discussionmentioning

confidence: 94%

“…Further, separate control of the endogenous MEL surge (through the signal via the pineal sympathetic innervation) on the one hand, and pineal sympathetic responsiveness on the other, was shown by observation of an approximate 4-fold response of pineal MEL (similar to the one in intact animals) after nocturnal injection of norepinephrine and desmethylimiprimine in hamsters previously subjected to superior cervical ganglionectomy (8).…”

Section: Syrian Hamster Pineal Sympathetic Responsiveness In the Earlmentioning

confidence: 99%

See 3 more Smart Citations

U.S. Army Institute of Surgical Research Annual Research Progress Report for Fiscal Year 1989

Pruitt¹

1989

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 83%

“…However, ganglionectomy did not lead to supersensitivity (5,8), again suggesting that responsiveness itself may be independent of sympathetic input at the level of the pinealocyte.…”

Section: Discussionmentioning

confidence: 94%

Section: Syrian Hamster Pineal Sympathetic Responsiveness In the Earlmentioning

confidence: 99%

See 2 more Smart Citations

U.S. Army Institute of Surgical Research Annual Research Progress Report for Fiscal Year 1989

Pruitt¹

1989

View full text Add to dashboard Cite

“…The increased V observed coupled with the association between the number of days from burn injury and AUC, with the AUCs approaching those seen for healthy volunteers later in the burn injury, supports the hypothesis that daptomycin is cleared through the burn wounds. Patients with burn injury experience protein loss across burn wounds (12). Since daptomycin is highly protein bound, it may be being eliminated in conjunction with the protein loss during this early postburn phase.…”

mentioning

confidence: 99%

Pharmacokinetic Evaluation of Single-Dose Intravenous Daptomycin in Patients with Thermal Burn Injury

Mohr

Ostrosky-Zeichner

Wainright

et al. 2008

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Daptomycin pharmacokinetics were evaluated for burn patients. Burn patients had decreases in the maximum concentration of the drug in serum (44%) and the area under the concentration-time curve (47%) and increases in the volume of distribution (64%) and total clearance (77%) compared to healthy volunteers. In burn patients, daptomycin at 10 to 12 mg/kg of body weight/day would be required to achieve drug exposures similar to those for healthy volunteers receiving 6 mg/kg.Daptomycin is a novel lipopeptide antibiotic with potent in vitro activity against gram-positive bacteria, including antimicrobial-resistant strains (10). Daptomycin is approved for the treatment of complicated skin and skin structure infections and bloodstream infections, including right-sided endocarditis caused by methicillin-susceptible and -resistant Staphylococcus aureus strains. Patients with thermal burn injury are at risk of developing burn wound infections and bacteremia caused by gram-positive organisms, including drug-resistant organisms (11). Evaluation of the effect of burn injury on the deposition of daptomycin is essential to appropriate dosing in this special population. The purpose of this study was to describe daptomycin pharmacokinetics for patients with thermal burn injury and compare those parameters with those previously reported for healthy volunteers.(These data were presented in part at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, September 2007.) This was an open-label, single-center, pharmacokinetic study in patients with Ն18% body surface area burns who were at least 7 days after burn injury and had completed their initial fluid resuscitation. The study was approved by the Committee for the Protection of Human Subjects, the Institutional Review Board for the University of Texas Health Science Center at Houston. Patients were excluded if their actual body weight was Ͼ30% of their ideal body weight for height or if they had serum glutamic pyruvic transaminase or serum glutamic oxaloacetic transaminase values of Ն4 times the upper normal limit of normal, creatine phosphokinase values of Ն5 times the upper limit of normal, or estimated creatinine clearance of Յ30 ml/min or were receiving continuous renal replacement therapy. Patients received a single 30-min intravenous infusion of 6 mg of daptomycin/kg of body weight based on the patient's actual body weight via infusion pump. Plasma samples were obtained at 0.5, 1, 2, 4, 8, 12, and 24 h after the start of the infusion. Serum samples were obtained at 1, 2, and 8 h to determine protein binding. All urine was collected and refrigerated from drug administration through 48 h after dosing. All samples were stored at Ϫ70°C until analysis.Daptomycin plasma and urine concentrations were analyzed using reverse-phase high-performance liquid chromatography with UV detection at 220 nm over a range of concentrations from 2 to 100 g/ml (7). The intrarun percent coefficients of variation for the low-quality control of 4 g/ml and the h...

show abstract