Thermal injury and changes in the trace elements

Bang, Rameshwar L.; Mattappallil, A.B.; Dashti, H.; Al-Bader, A.

doi:10.1002/1520-670x(2000)13:3<255::aid-jtra2>3.0.co;2-j

Cited by 3 publications

(4 citation statements)

References 27 publications

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“…After the thermal injury, the zinc level decreased in plasma within less than 6 h. The plasma zinc decrease was more important in DG rats than in control rats (NG) as soon as day 1. These results partially fit with other studies reporting the early decrease of serum zinc level after burn injury [14,15]. This modification of zinc metabolism could be related to the generalization of the burninduced inflammatory response, glucocorticoid release, and albumin decrease.…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies reported the impairment of the trace element status after burn injury [15] and the benefits of micronutrient supplementation on the recovery of burn injury [24]. Among these trace elements, zinc seems to play a key role [16].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, zinc is known to have an insulinomimetic action by increasing peripheral glucose disposal [11,12] and by stimulating lipogenesis [13]. In burned patients, previous clinical studies have demonstrated the decrease in zinc status [14,15], as a consequence of both large exudative losses through the burned areas and exacerbated urinary losses [16]. This decline may become critical if the patients exhibit marginal zinc status before burn injury [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Sub-deficient Zinc Status on Insulin Sensitivity after Burn Injury in Rats

Claeyssen

Andriollo-Sanchez

Arnaud

et al. 2008

Biol Trace Elem Res

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Although zinc status is an important parameter in insulin sensitivity, data concerning its implication in noxious burn-induced insulin resistance are scarce. The present study was designed to evaluate the impact of zinc status before burn on the recovery of injury with focus on plasma insulin and glucose levels. The experiment was performed in male adult Wistar rats fed from weaning with a zinc normal diet (80 ppm) or a depleted zinc diet (10 ppm) for 8 weeks and burned to third degree on 20% of their total body surface area. Blood and tissue samples were collected 3, 6, and 24 h after injury in order to study biochemical parameters and the glucose/insulin response in relation with the zinc status. After burn, zinc-depleted rats presented an exacerbated decrease in plasma zinc level. In addition, the burn-induced insulin resistance, leading to protein catabolism, was emphasized, with higher plasma insulin, glucose, and leptin levels in zinc-deficient animals versus normal-fed rats. Our experimental results underlined the interest to early control the zinc status in order to limit the deleterious effects of oxidative stress and insulin resistance in burned patients.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Sub-deficient Zinc Status on Insulin Sensitivity after Burn Injury in Rats

Claeyssen

Andriollo-Sanchez

Arnaud

et al. 2008

Biol Trace Elem Res

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“…The detailed method used to measure serum selenium was as previously described from our research laboratory [11]. Copper, zinc, and magnesium were assayed by flame atomic absorption spectrometry (Varian Model, spectra AA 300/400), whereas selenium was estimated by a graphite tube atomizer (GTA-96).…”

Section: Methodsmentioning

confidence: 99%