Protein metabolism after injury

Fleck, A.

doi:10.1079/pns19710027

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…The metabolism of albumin has been extensively studied in pathological conditions [e.g., Davies [1968] in the rabbit suggests an early reduction in synthesis [Fleck, 1971;Ballantyne et a!., 1971] which may be due to diminished food intake at this time.…”

Section: Protein Requirementsmentioning

confidence: 99%

Nutrition in the Post-Traumatic Period

et al. 1972

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The early depression of metabolism, local and general, immediately following injury other than mild trauma – ‘the ebb phase’ – lasts some hours. It is then generally followed by a period of enhanced heat production and the early hyperglycaemía gives way to an excess of protein catabolism over anabolism which is more general than local – ‘the flow phase’. These are at their height 5–8 days after injury and the excess urinary nitrogen excretion is paralleled by increases in urinary sulphur, phosphorus, potassium, magnesium, zinc and creatine. Hospitalisation in a warm (28–30 °C) and relatively dry environment will reduce this excessive catabolism. Where there is inability to ingest, digest or absorb sufficient food over a period of several days and the patient’s condition is likely to deteriorate, then recourse must be made to intraduodenal or jejunal feeding or to parenteral feeding. The amino acid requirements for replacement of haemoglobin if it has not been done through appropriate transfusion can be particularly demanding in respect of certain amino acids. Obviously the non-amino acid sources of energy, as well as the other nutrients, should be suitable for the optimal utilisation of the infused amino acids.

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Section: Protein Requirementsmentioning

confidence: 99%

Nutrition in the Post-Traumatic Period

et al. 1972

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“…The size of the response is related to the amount of protein in the diet before the injury and it is not observed if the animals have been kept on a protein-free diet before being injured (Munro and Cuthbertson, 1943;Munro and Chalmers, 1945;Cairnie et al, 1957). This implies that the protein broken down in this response is first drawn from the labile protein stores held in muscle (Fleck and Munro, 1963;Munro, 1964). Work of this type has shown that these changes associated with the 'flow' period are not essential for recovery since the rate of healing does not depend on the size 52 of the response.…”

Section: 'Flow' Periodmentioning

confidence: 99%

Energy metabolism after injury.

Stoner¹

1970

Journal of Clinical Pathology

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“…In contrast, when experimental animals have been fed adequate energy but very low or no protein, albumin concentration has been found to fall significantly within a few days. 23 The administration of hydrocortisone to man has been shown to increase the rate of catabolism of albumin.j" Finally, there is experimental evidence to indicate that the fractional catabolic rate of albumin is directly proportional to albumin concentration, so that as concentration increases the catabolic rate also increases.P In contrast, the fractional synthesis rate of albumin is inversely proportional to its concentra- …”

Section: Computer Model For Determining Causes Of Changes In Concementioning

confidence: 99%

Computer Models for Metabolic Studies on Plasma Proteins

Fleck

1985

Ann Clin Biochem

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Protein metabolism after injury

Cited by 8 publications

References 21 publications

Nutrition in the Post-Traumatic Period

Nutrition in the Post-Traumatic Period

Energy metabolism after injury.

Computer Models for Metabolic Studies on Plasma Proteins

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