Protein modified upconversion nanoparticles for imaging-guided combined photothermal and photodynamic therapy

Chen, Qian; Wang, Chao; Cheng, Liang; He, Weiwei; Zhang, Cheng; Liu, Zhuang

doi:10.1016/j.biomaterials.2013.12.046

Cited by 301 publications

(213 citation statements)

References 42 publications

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“…Since Zhang et al 32 first demonstrated the application of UCNP-based nanocomposite for PDT of bladder cancer cells, recent advances in the integration of UCNPs with PSs such as chlorin e6, Rose Bengal, and IR825 (an NIR-absorbing dye) for their PDT applications in vitro and in vivo have created many excitements. [33][34][35] However, the phototoxic effect of 1 O 2 on PDT is restricted because of a hypoxic condition in tumor tissue. 36 Therefore, it is important to develop NIR light-triggered and -targeted theranostic platform for imaging-guided PDT of cancer under low-oxygen conditions.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional upconversion–nanoparticles–trismethylpyridylporphyrin–fullerene nanocomposite: a near-infrared light-triggered theranostic platform for imaging-guided photodynamic therapy

Guan

Dong

et al. 2015

NPG Asia Mater

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Photodynamic therapy (PDT) is an excellent therapeutic modality for various malignant and nonmalignant cancers. This approach utilizes reactive oxygen species generated through the reaction between photosensitizer and oxygen in tissues upon light irradiation to achieve effective treatment. However, limited penetration depth and oxygen-deficient microenvironment hinder the efficiency of PDT. In this work, we design a multifunctional near-infrared (NIR)-triggered theranostic agent based on upconversion-nanoparticles-Polyoxyethylene bis (amine)-trismethylpyridylporphyrin-fullerene nanocomposite (UCNP-PEG-FA/ PC 70 ) for imaging (fluorescence/upconversion luminescence/magnetic resonance imaging)-guided photodynamic therapy. In this multimodal nanocompsite, UCNPs are employed as light transducers to convert NIR light into ultraviolet-visible light to activate PC 70 to generate singlet oxygen ( 1 O 2 ) even under low-oxygen conditions. Meanwhile, the upconversion emission, magnetic resonance imaging and fluorescence signal coming from UCNPs and PC 70 nanocomposite enable UCNP-PEG-FA/PC 70 to act as a multimodal imaging diagnostic agent, which facilitates the imaging-guided PDT. Furthermore, folate-mediated active targeting would enhance the accumulation of multifunctional hybrid in tumor. In vitro as well as in vivo results suggest that this smart nanocomposite is promising as an NIR light-triggered and -targeted theranostic platform for imaging-guided PDT of cancer, which may provide a solution to the bottleneck problems of PDT, namely, limited penetration depth and oxygen-deficient microenvironment.

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Section: Introductionmentioning

confidence: 99%

Multifunctional upconversion–nanoparticles–trismethylpyridylporphyrin–fullerene nanocomposite: a near-infrared light-triggered theranostic platform for imaging-guided photodynamic therapy

Guan

Dong

et al. 2015

NPG Asia Mater

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“…A popular host material is NaYF 4 , which exhibits high upconversion efficiency due to the low phonon cutoff energy, 15 thus attracting much interest in UCNs-based PDT and upconversion luminescence (UCL) imaging. [16][17][18][19] Other fluorides containing Yb 3+ (NaYbF 4 ) and Gd 3+ (NaGdF 4 ) ions, which also function as computed tomography (CT) and magnetic resonance imaging (MRI) contrast agents, [20][21][22][23][24] have been utilized to achieve simultaneous dual-or multimodal bioimaging with high sensitivity and high spatial resolution. These multifunctional nanoparticles can satisfy the high efficiency and accuracy requirements of clinical cancer theranostics.…”

Section: Liu Et Almentioning

confidence: 99%

Magnetic and fluorescent Gd2O3:Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy

Li¹,

Huang²,

Tian³

et al. 2016

IJN

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“…Two kinds of material were selected for the surface modification of UCNPs to achieve the dual function of PTT and PDT. Bengal Rose was used to absorb the green fluorescence of UCNP to realize the PTT, and the infrared absorption dye of IR825 was used to realize PDT [107]. The Bu team reported a MRI/NIR dual-modal nanoparticle, which can treat tumor with chemo-/ radio-/ photodynamic modals [108].…”

Section: Ucnps For Cancer Therapymentioning

confidence: 99%

Up-Conversion Nanoparticles for Gastric Cancer Targeted Imaging and Therapy

Yang¹,

Han²,

Yue³

2016

Nano BioMed ENG

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As a new generation of fluorophores, up-conversion nanoparticles (UCNPs) exhibit high penetration depth in tissues, low photodamage to biological samples, large Stokes shifts, sharp emission bands, free auto-fluorescence background and high photostability, thus making them an ideal kind of fluorescent labels for a variety of assay formats ranging from bio-imaging to cancer therapy. In this article, the method for the synthesis of biocompatible UCNPs, the recent progress regarding the UCNPs for multimodal targeted tumor imaging, drug delivery, photodynamic therapy (PDT), and photothermal therapy (PTT) are discussed on emphasis. The challenges and opportunities in this emerging field are also presented.

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Protein modified upconversion nanoparticles for imaging-guided combined photothermal and photodynamic therapy

Cited by 301 publications

References 42 publications

Multifunctional upconversion–nanoparticles–trismethylpyridylporphyrin–fullerene nanocomposite: a near-infrared light-triggered theranostic platform for imaging-guided photodynamic therapy

Multifunctional upconversion–nanoparticles–trismethylpyridylporphyrin–fullerene nanocomposite: a near-infrared light-triggered theranostic platform for imaging-guided photodynamic therapy

Magnetic and fluorescent Gd<sub>2</sub>O<sub>3</sub>:Yb<sup>3+</sup>/Ln<sup>3+</sup> nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy

Up-Conversion Nanoparticles for Gastric Cancer Targeted Imaging and Therapy

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