Protein Nanocarriers for Targeted Drug Delivery for Cancer Therapy

Heggannavar, Geetha B.; Amado, Sandra; Mitchell, Geoffrey R.

doi:10.1016/b978-0-12-814033-8.00006-0

Cited by 18 publications

(12 citation statements)

References 70 publications

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“…Zein exhibits several attractive attributes as a printable material. Zein is biodegradable, edible, has been classified as “generally recognized as safe” by the U.S. Food and Drug Administration (FDA), and has been used in biomedical applications, such as coatings for pharmaceutical capsules, ,, fabrication of scaffolds for cell culture, and synthesis of nanoparticles, fibers, and membranes for controlled drug release.…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Printing Using a Maize Protein: Zein-Based Inks in Biomedical Applications

Negrete

Aceves-Colin

Rivera-Flores

et al. 2021

ACS Biomater. Sci. Eng.

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The use of three-dimensional (3D) printing for biomedical applications has expanded exponentially in recent years. However, the current portfolio of 3D printable inks is still limited. For instance, only few protein matrices have been explored as printing/bioprinting materials. Here, we introduce the use of zein, the primary constitutive protein in maize seeds, as a 3D printable material. Zein-based inks were prepared by dissolving commercial zein powder in ethanol with or without polyethylene glycol (PEG400) as a plasticizer. The rheological characteristics of our materials, studied during 21 days of aging/maturation, showed an increase in the apparent viscosity as a function of time in all formulations. The addition of PEG400 decreased the apparent viscosity. Inks with and without PEG400 and at different maturation times were tested for printability in a BioX bioprinter. We optimized the 3D printing parameters for each ink formulation in terms of extrusion pressure and linear printing velocity. Higher fidelity structures were obtained with inks that had maturation times of 10 to 14 days. We present different proof-of-concept experiments to demonstrate the versatility of the engineered zein inks for diverse biomedical applications. These include printing of complex and/or free-standing 3D structures, tablets for controlled drug release, and scaffolds for cell culture.

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Section: Introductionmentioning

confidence: 99%

Three-Dimensional Printing Using a Maize Protein: Zein-Based Inks in Biomedical Applications

Negrete

Aceves-Colin

Rivera-Flores

et al. 2021

ACS Biomater. Sci. Eng.

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“…Hence, the chemical bonding with polymer chains increases the hydrodynamic volume while offering improved solubility, better physiological stability, and reduced immunogenicity [13,52]. The covalent conjugation with PEG polymers, also known as PEGylation, is one of the widespread strategies used for protein guarding and stabilization [54,55]. To date, over 10 PEGylated therapeutic proteins have been approved by the FDA, including Adagen ® , Somavert ® , Oncaspar ® , and Naloxego ® , which have been introduced to the pharmaceutical market, whilst other products are in clinical development [56].…”

Section: Chemical Bonding Of Polymer Chains With Proteinmentioning

confidence: 99%

Polymeric Nanostructures Containing Proteins and Peptides for Pharmaceutical Applications

2022

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Over the last three decades, proteins and peptides have attracted great interest as drugs of choice for combating a broad spectrum of diseases, including diabetes mellitus, cancer, and infectious and neurological diseases. However, the delivery of therapeutic proteins to target sites should take into account the obstacles and limitations related to their intrinsic sensitivity to different environmental conditions, fragile tertiary structures, and short half-life. Polymeric nanostructures have emerged as competent vehicles for protein delivery, as they are multifunctional and can be tailored according to their peculiarities. Thus, the enhanced bioavailability and biocompatibility, the adjustable control of physicochemical features, and the colloidal stability of polymer-based nanostructures further enable either the embedding or conjugation of hydrophobic or hydrophilic bioactive molecules, which are some of the features of paramount importance that they possess and which contribute to their selection as vehicles. The present review aims to discuss the prevalent nanostructures composed of block copolymers from the viewpoint of efficient protein hospitality and administration, as well as the up-to-date scientific publications and anticipated applications of polymeric nanovehicles containing proteins and peptides.

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“…Since both the polymers utilized in nanoparticle production have skin benefits, the study investigates the fate of the NPs after skin application by tracking their skin distribution follow ing the penetration of the emulsion droplets. During the complex chitosan/collagen peptides nanoparticle formation, the long chitosan chains fold around the collagen peptides and form a new phase complex having different properties from that of the individua components [37]. The process of Emulsification/Solvent Extraction has been illustrated in Figure 1.…”

Section: Emulsification/solvent Extractionmentioning

confidence: 99%

Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

et al. 2021

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The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

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Protein Nanocarriers for Targeted Drug Delivery for Cancer Therapy

Cited by 18 publications

References 70 publications

Three-Dimensional Printing Using a Maize Protein: Zein-Based Inks in Biomedical Applications

Three-Dimensional Printing Using a Maize Protein: Zein-Based Inks in Biomedical Applications

Polymeric Nanostructures Containing Proteins and Peptides for Pharmaceutical Applications

Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

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