Protein‐Nanoreactor‐Assisted Synthesis of Semiconductor Nanocrystals for Efficient Cancer Theranostics

Yang, Tao; Wang, Yong; Ke, Hengte; Wang, Qiaoli; Lv, Xiaoyan; Wu, Hong; Tang, Yong’an; Yang, Xiangliang; Chen, Chunying; Zhao, Yuliang; Chen, Huabing

doi:10.1002/adma.201506119

Cited by 181 publications

(142 citation statements)

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“…Recently, BSA was used as a nanoreactor to prepare theranostic agents. 22 This improved biological compatibility and controlled size. These agents achieved more efficient cancer-detection rates and better treatments in vivo.…”

Section: +mentioning

confidence: 97%

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BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

Mu¹,

Yan²,

Tian³

et al. 2017

IJN

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Protein-related nanotheranostic agents hold great promise as tools to serve many clinical applications. Proteins such as BSA are used to regulate the synthesis of nondegradable inorganic nanoparticles (NPs). To fully employ the potential of such proteins, a new type of biosafe nanotheranostic agent must be designed to optimize BSA as a biomineralization agent. Here, a straightforward BSA-assisted biomineralization method was developed to prepare gallic acid (GA)–Fe(III) coordination polymer NPs. BSA-coated GA-Fe (GA-Fe@BSA) NPs were ultrasmall (3.5 nm) and showed good biocompatibility, a lower r 2 : r 1 ratio (1.06), and strong absorption in the visible near-infrared region. T 1 -weighted magnetic resonance imaging of tumor-bearing mice before and after intratumoral injection with GA-Fe@BSA NPs definitively demonstrated positive change. In a subsequent in vivo study, antitumor activity was precipitated by intratumoral injection of GA-Fe@BSA NPs combined with laser treatment, suggesting excellent outcomes with this treatment method. These results describe a successful protocol in which BSA regulated the synthesis of benign organic polymer NPs. GA-Fe@BSA NPs have the potential to be ideal agents to be used in clinical theranostic nanoplatforms.

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Section: +mentioning

confidence: 97%

“…22 Research has shown a significant difference between the functions of HSA and BSA. 23 The high homology and low cost of BSA makes it an appropriate research proxy for HSA.…”

Section: +mentioning

confidence: 99%

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

Mu¹,

Yan²,

Tian³

et al. 2017

IJN

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“…For example, Chen and co‐workers prepared a series of metal sulfide NPs by using proteins as a nanoreactor, where metal salts and sulfur resource (Na 2 S) were introduced to prepare protein encapsulated metal sulfide NPs. The metal sulfide NPs demonstrated an excellent platform for cancer therapy . Similarly, size‐controlled and biocompatible Ag 2 S NPs were developed as a second near‐infrared imaging agent for cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Dual Roles of Protein as a Template and a Sulfur Provider: A General Approach to Metal Sulfides for Efficient Photothermal Therapy of Cancer

Sheng

Wang

Han

et al. 2017

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129

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Fabrication of clinically translatable nanoparticles (NPs) as photothermal therapy (PTT) agents against cancer is becoming increasingly desirable, but still challenging, especially in facile and controllable synthesis of biocompatible NPs with high photothermal efficiency. A new strategy which uses protein as both a template and a sulfur provider is proposed for facile, cost‐effective, and large‐scale construction of biocompatible metal sulfide NPs with controlled structure and high photothermal efficiency. Upon mixing proteins and metal ions under alkaline conditions, the metal ions can be rapidly coordinated via a biuret‐reaction like process. In the presence of alkali, the inert disulfide bonds of S‐rich proteins can be activated to react with metal ions and generate metal sulfide NPs under gentle conditions. As a template, the protein can confine and regulate the nucleation and growth of the metal sulfide NPs within the protein formed cavities. Thus, the obtained metal sulfides such as Ag2S, Bi2S3, CdS, and CuS NPs are all with small size and coated with proteins, affording them biocompatible surfaces. As a model material, CuS NPs are evaluated as a PTT agent for cancer treatment. They exhibit high photothermal efficiency, high stability, water solubility, and good biocompatibility, making them an excellent PTT agent against tumors. This work paves a new avenue toward the synthesis of structure‐controlled and biocompatible metal sulfide NPs, which can find wide applications in biomedical fields.

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“…A lot of drug delivery systems have been developed to realize combination chemotherapy and photothermal ablation. For instance, chemical drugs were directly loaded in photothermal nanoparticles, such as gold,19, 20, 21, 22 sulfide,23, 24, 25, 26 graphene and graphene‐like materials,27, 28, 29, 30 Prussian blue;31, 32 or loaded in mesoporous silica, smart polymer, aptamer, and cleavable linkages etc. modified on the photothermal particles 33, 34.…”

Section: Introductionmentioning

confidence: 99%

NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy

Wang

Yang

et al. 2018

Advanced Science

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Construction of localized drug‐eluting systems with synergistic chemothermal tumor‐killing abilities is promising for biomedical implants directly contacting with tumor tissues. In this study, an intelligent and biocompatible drug‐loading platform, based on a gold nanorods‐modified butyrate‐inserted NiTi‐layered double hydroxides film (Au@LDH/B), is prepared on the surface of nitinol alloy. The prepared films function as drug‐loading “sponges,” which pump butyrate out under near‐infrared (NIR) irradiation and resorb drugs in water when the NIR laser is shut off. The stimuli‐responsive release of butyrate is verified to be related with the NIR‐triggered crystal phase transformation of Au@LDH/B. In vitro and in vivo studies reveal that the prepared films possess excellent biosafety and high efficiency in synergistic thermochemo tumor therapy, showing a promising application in the construction of localized stimuli‐responsive drug‐delivery systems.

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Protein‐Nanoreactor‐Assisted Synthesis of Semiconductor Nanocrystals for Efficient Cancer Theranostics

Abstract: Transition metal sulfide nanocrystals are developed as a theranostic platform through the protein-nanoreactor approach with facile functionalization for multimodal NIRF/PA/SPECT/CT imaging and photothermal tumor ablation.

Cited by 181 publications

References 50 publications

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

Dual Roles of Protein as a Template and a Sulfur Provider: A General Approach to Metal Sulfides for Efficient Photothermal Therapy of Cancer

NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy

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Protein‐Nanoreactor‐Assisted Synthesis of Semiconductor Nanocrystals for Efficient Cancer Theranostics

Abstract: Transition metal sulfide nanocrystals are developed as a theranostic platform through the protein-nanoreactor approach with facile functionalization for multimodal NIRF/PA/SPECT/CT imaging and photothermal tumor ablation.

Cited by 181 publications

References 50 publications

BSA-assisted synthesis of ultrasmall gallic acid&ndash;Fe(III) coordination polymer nanoparticles for cancer theranostics

BSA-assisted synthesis of ultrasmall gallic acid&ndash;Fe(III) coordination polymer nanoparticles for cancer theranostics

Dual Roles of Protein as a Template and a Sulfur Provider: A General Approach to Metal Sulfides for Efficient Photothermal Therapy of Cancer

NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy

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BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics