Protein supplementation lowers blood pressure in overweight adults: effect of dietary proteins on blood pressure (PROPRES), a randomized trial

Teunissen-Beekman, Karianna F. M.; Dopheide, J.; Geleijnse, Johanna M.; Bakker, Stephan J. L.; Brink, Elizabeth J.; Leeuw, Peter W. de; Baak, Marleen A. van

doi:10.3945/ajcn.111.029116

Cited by 35 publications

(53 citation statements)

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“…Although trials studying the effect of dietary proteins on BP have produced inconsistent results (1)(2)(3)(4)(5), the randomized clinical trial on the effects of PROteins on blood PRESsure (PROPRES) has shown that 4 wk of protein supplementation is able to lower BP in overweight men and women with untreated elevated BP as compared with 4 wk of maltodextrin supplementation (6). A subgroup of the PROPRES participants participated in the present substudy addressing possible mechanisms involved in the BP-lowering effect of proteins.…”

Section: Introductionmentioning

confidence: 98%

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Blood Pressure Decreases More after High-Carbohydrate Meals Than after High-Protein Meals in Overweight Adults with Elevated Blood Pressure, but There Is No Difference after 4 Weeks of Consuming a Carbohydrate-Rich or Protein-Rich Diet

Teunissen-Beekman

Dopheide

Geleijnse

et al. 2013

The Journal of Nutrition

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The replacement of dietary carbohydrates with proteins can lower blood pressure (BP), but the mechanisms remain unclear. This randomized, double-blind, parallel-group study aimed to compare 12-h postprandial sympathetic and hemodynamic responses after high-protein (HP) meals and high-carbohydrate (HC) meals. Fifty-two men and women with untreated elevated BP were tested on d 1 and after 4 wk of supplementation [3 × 20 g protein (HP) or maltodextrin (HC) per day]. No between-group differences were found in postprandial plasma norepinephrine on d 1 and at wk 4. On d 1, postprandial mean arterial pressure (MAP) decreased more in the HC group than in the HP group (P = 0.002). This difference was not present at 4 wk, because the postprandial decline in MAP tended to become larger in the HP group after 4 wk of supplementation (P = 0.07). On both test days, postprandial total peripheral resistance tended to decrease more in the HC group (P < 0.08). After 4 wk of supplementation, cardiac output tended to increase more in the HC group (P = 0.08). In conclusion, ingestion of an HP diet induced a smaller decrease in BP on d 1 than did ingestion of an HC diet. This difference disappeared after 4 wk due to a more pronounced decrease in BP in the HP group after 4 wk than on d 1. These findings cannot explain the BP-lowering effect ascribed to dietary proteins.

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Section: Introductionmentioning

confidence: 98%

“…The aim of this substudy was to compare changes in SNS activity and postprandial hemodynamics induced by protein-and carbohydrateenriched meals. Postprandial responses were observed for 12 h (including breakfast, lunch, and dinner) at d 1 and after 4 wk of protein or maltodextrin supplementation in the PROPRES intervention study (6).…”

Section: Introductionmentioning

confidence: 99%

Blood Pressure Decreases More after High-Carbohydrate Meals Than after High-Protein Meals in Overweight Adults with Elevated Blood Pressure, but There Is No Difference after 4 Weeks of Consuming a Carbohydrate-Rich or Protein-Rich Diet

Teunissen-Beekman

Dopheide

Geleijnse

et al. 2013

The Journal of Nutrition

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“…Randomized trials in obese patients with type 2 diabetes found that a high protein diet was more effective in reducing BP compared with a low protein diet, both when exchanged for carbohydrate [17] or fat [18]. Also in an intervention study among 99 obese men and women with elevated BP protein supplementation resulted in a 4.6 AE 1.7 mmHg stronger BP decrease than maltodextrine supplementation [19]. With respect to specific types of protein, several cohort studies in nondiabetic individuals showed an inverse association between plant protein intake and BP [20,21], whereas no association was observed between animal protein intake and BP [20,21].…”

Section: Introductionmentioning

confidence: 88%

Protein intake in relation to risk of hypertension and microalbuminuria in patients with type 1 diabetes

Kuil¹,

Engberink²,

IJpma³

et al. 2013

Journal of Hypertension

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Results from our study did not provide evidence that a protein intake commonly consumed by European patients with type 1 diabetes is associated with incident hypertension or microalbuminuria. Prospective studies with more detailed information on dietary intake (including mineral intake) are needed to confirm these findings, and to investigate the impact on vascular and renal complications of a long-term very high protein intake in patients with type 1 diabetes.

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“…There was a non-significant reduction in DBP. Another RDB parallel study over 4 wk of 94 subjects with prehypertension and stage Ⅰ hypertension found significant reductions on office BP of 4.9/2.7 mmHg in those given a combination of 25% protein intake vs the control group given 15% protein in an isocaloric manner [101] . The protein consisted of 20% pea, 20% soy, 30% egg and 30% milk-protein isolate [101] .…”

Section: Proteinmentioning

confidence: 99%

“…Another RDB parallel study over 4 wk of 94 subjects with prehypertension and stage Ⅰ hypertension found significant reductions on office BP of 4.9/2.7 mmHg in those given a combination of 25% protein intake vs the control group given 15% protein in an isocaloric manner [101] . The protein consisted of 20% pea, 20% soy, 30% egg and 30% milk-protein isolate [101] . The daily recommended intake of protein from all sources is 1.0 to 1.5 g/kg body weight, varying with exercise level, age, renal function and other factors [1,70,71] .…”

Section: Proteinmentioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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Protein supplementation lowers blood pressure in overweight adults: effect of dietary proteins on blood pressure (PROPRES), a randomized trial

Abstract: Increased protein intake, at the expense of maltodextrin, lowers BP in overweight adults with upper-range prehypertension and grade 1 hypertension. This trial was registered at www.trialregister.nl as NTR 1362.

Cited by 35 publications

References 25 publications

Blood Pressure Decreases More after High-Carbohydrate Meals Than after High-Protein Meals in Overweight Adults with Elevated Blood Pressure, but There Is No Difference after 4 Weeks of Consuming a Carbohydrate-Rich or Protein-Rich Diet

Blood Pressure Decreases More after High-Carbohydrate Meals Than after High-Protein Meals in Overweight Adults with Elevated Blood Pressure, but There Is No Difference after 4 Weeks of Consuming a Carbohydrate-Rich or Protein-Rich Diet

Protein intake in relation to risk of hypertension and microalbuminuria in patients with type 1 diabetes

The role of nutrition and nutraceutical supplements in the treatment of hypertension

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