Protein synergistic action-based development and application of a molecularly imprinted chiral sensor for highly stereoselective recognition of S-fluoxetine
“…Proteins have been considered a satisfactory alternative for chiral sensing owing to their stereoselective characteristics. 90,91 'Chiral transfer' strategy facilitates the simple preparation of protein-based sensors by imparting chirality from chiral proteins to achiral NMs. Based on the prominent advantages of NMs, protein-NM complexes can be utilized for fabricating chiral electrochemical and plasmonic sensors with improved sensitivity.…”
Section: Creating a Cooperative Relationship Between Proteins And Nan...mentioning
The cooperation relation between biomolecules and nanomaterials makes up a beautiful tale about nanoscale chiral sensing and separation. Biomolecules are considered a fabulous chirality ‘donor’ to develop chiral sensors and...
“…Proteins have been considered a satisfactory alternative for chiral sensing owing to their stereoselective characteristics. 90,91 'Chiral transfer' strategy facilitates the simple preparation of protein-based sensors by imparting chirality from chiral proteins to achiral NMs. Based on the prominent advantages of NMs, protein-NM complexes can be utilized for fabricating chiral electrochemical and plasmonic sensors with improved sensitivity.…”
Section: Creating a Cooperative Relationship Between Proteins And Nan...mentioning
The cooperation relation between biomolecules and nanomaterials makes up a beautiful tale about nanoscale chiral sensing and separation. Biomolecules are considered a fabulous chirality ‘donor’ to develop chiral sensors and...
“…Molecular sensors have been successfully applied in many fields of science, ranging from biotechnology to aerospace engineering. [1][2][3][4][5][6] Data obtained from molecular optical sensors carry information about parameters, such as polarity, in proximity to the sensing molecule. [7][8][9][10][11][12][13][14][15][16][17][18] The sensitivity of a fluorescent molecule to changes in particular environmental parameters depends mainly on the chemical structure of the sensor, which determines its absorption-emission behavior, called the detection mechanism.…”
The fluorescence of chemical compounds depends on a variety of chemical and physical factors. Two of them are viscosity and polarity; however, in the case of fluorescent sensing, external factors...
“…Recently, the use of multifunctional enantiomeric sensors to identify different enantiomers has become a good alternative technology for chiral recognition. 15 The application of chiral recognition can be further expanded by modifying β-CD on a variety of materials, 16 such as graphene, 17 organic field effect transistors (OFETs), 18 inorganic nanoparticles, 19 COFs, 20 and so on. When β-CD is modified on graphene and an OFET, the enantiomer recognition ability mainly relies on the changes in the electrical signals observed.…”
In Nature, enantiomers are pairs of chiral compounds, which have semblable chemical and physical properties but most show opposite biological effects when they enter the organism. Therefore, chiral recognition has...
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