Protein Transduction Domain Mimics: The Role of Aromatic Functionality

Abstract

Synthetische polymere Mimetika von Proteintransduktionsdomänen offenbaren, dass aromatische Seitenketten bei gleicher relativer Hydrophobie eine bessere Transduktion bieten als aliphatische Gruppen. Auch ist eine weniger hydrophobe aromatische Seitenkette aktiver als die entsprechende aliphatische mit gleicher Zahl von Kohlenstoffatomen (siehe Bild).

Facile Synthesis of Silver Nanoparticles Stabilized by Cationic Polynorbornenes and Their Catalytic Activity in 4-Nitrophenol Reduction

“…30 Additionally, the cell-permeating activities of polyarginines, 32,33 synthetic guanidinium-containing polymers, 34,35 and, in particular, the PG reported here 36 have recently led to the development of several other polynorbornene derivatives that efficiently act as protein transduction mimics. 37 While several groups have fabricated and evaluated the antimicrobial properties of materials consisting of silver nanoparticles and cationic polymers such as polyvinylpyridines 38 and polyethylenimine, 39 there are no analogous studies in the literature using membrane-penetrating norbornene-type cationic polymers as stabilizing agents. Here we report the facile synthesis of silver nanoparticles stabilized by PA and PG as tracked with UV spectroscopy, IR spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM).…”

“…This reduction is unfeasible in the presence of the strong reducing agent, NaBH 4 without the nanoparticle catalyst. Since polyguanidino oxanorbornene (PG) is watersoluble and biocompatible, 30,37 PG-protected nanoparticles may be comfortably integrated into systems related to drug delivery, biomedical, pharmaceutical, and biosensor applications. Exploitation of such polymer-bound nanoparticles in the area of biomolecular and catalytic applications has tremendous potential in the development of nanotechnologies related to medicine.…”

Synthesis of an Enlarged Library of Dynamic DNA Activators with Oxime, Disulfide and Hydrazone Bridges

“…The unique characteristics of dynamic amphiphiles are of interest in the context of polyioncounterion transport systems. [1][2][3][4][7][8][9][10] In general, the movement of polyions across lipid bilayer membranes is strongly influenced by their counterions. Hydrophilic counterions are referred to as inactivators because they produce hydrophilic polyion-counterion complexes that do not interact with the membrane.…”

“…Dynamic amphiphiles with positively charged heads can thus activate DNA or RNA as cation transporters in lipid bilayer membranes. [8,9] Negatively charged dynamic amphiphiles can activate cell-penetrating peptides (CPPs, or protein transduction domains, PTDs) [7,10] as anion transporters. [11] In this context, dynamic amphiphiles offer several advantages.…”