Protein Tyrosine Phosphatases in Tumor Progression and Metastasis: Promoter or Protection?

Ferreira-Halder, Carmen Veríssima; Clerici, Stefano Piatto; Faria, Alessandra Valéria de Sousa; Oliveira, Patrícia; Cordeiro, Helon Guimarães; Akagi, Erica M.

doi:10.5772/intechopen.87963

Cited by 8 publications

(3 citation statements)

References 109 publications

(131 reference statements)

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“…A potential pathway by which intestinal microbes influence the tightness of a TJ seems to be through the rise in zonulin concentration, which is a novel indicator of intestinal permeability [49,50]. Faecalibacterium has been regarded as a next generation probiotic owing to its several healthpromoting and anti-inflammatory properties [51]. As noted above, there was a specific inflammatory profile along with the altered composition of gut microbiota in T1D patients [22,24,27].…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota Profile in Patients with Type 1 Diabetes Based on 16S rRNA Gene Sequencing: A Systematic Review

et al. 2020

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The gut microbiota has been presumed to have a role in the pathogenesis of type 1 diabetes (T1D). Significant changes in the microbial composition of T1D patients have been reported in several case-control studies. This study is aimed at systematically reviewing the existing literature, which has investigated the alterations of the intestinal microbiome in T1D patients compared with healthy controls (HCs) using 16S ribosomal RNA-targeted sequencing. The databases of MEDLINE, EMBASE, Web of Science, and the Cochrane Library were searched until April 2019 for case-control studies comparing the composition of the intestinal microbiome in T1D patients and HCs based on 16S rRNA gene sequencing techniques. The Newcastle-Ottawa Scale was used to assess the methodological quality. Ten articles involving 260 patients with T1D and 276 HCs were included in this systematic review. The quality scores of all included studies were 6–8 points. In summary, a decreased microbiota diversity and a significantly distinct pattern of clustering with regard to β-diversity were observed in T1D patients when compared with HCs. At the phylum level, T1D was characterised by a reduced ratio of Firmicutes/Bacteroidetes in the structure of the gut community, although no consistent conclusion was reached. At the genus or species level, T1D patients had a reduced abundance of Clostridium and Prevotella compared with HCs, whereas Bacteroides and Ruminococcus were found to be more enriched in T1D patients. This systematic review identified that there is a close association between the gut microbiota and development of T1D. Moreover, gut dysbiosis might be involved in the pathogenesis of T1D, although the causative role of gut microbiota remains to be established. Further well-controlled prospective studies are needed to better understand the role of the intestinal microbiome in the pathogenesis of T1D, which may help explore novel microbiota-based strategies to prevent and treat T1D.

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Section: Discussionmentioning

confidence: 99%

Gut Microbiota Profile in Patients with Type 1 Diabetes Based on 16S rRNA Gene Sequencing: A Systematic Review

et al. 2020

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“…As most kinases are demonstrated to play oncogenic role in cancer, and because of the opposing function of kinases and phosphatases, phosphatases are presumed as tumor suppressors [91]. However, in the last decades, a number of studies on the role of phosphatases demonstrated that the enzyme superfamily can be involved in either oncogenic or tumor suppressing processes [92]. For example, loss of many PTPs such as Phosphatases are demonstrated to regulate the function of phosphorylated proteins by physical interaction with their substrates through three different ways [77].…”

Section: Overview Of Protein Phosphatases Family and Their Roles In Cancermentioning

confidence: 99%

Interaction of the Hippo Pathway and Phosphatases in Tumorigenesis

Emami

Zhang

Yang

2020

Cancers

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The Hippo pathway is an emerging tumor suppressor signaling pathway involved in a wide range of cellular processes. Dysregulation of different components of the Hippo signaling pathway is associated with a number of diseases including cancer. Therefore, identification of the Hippo pathway regulators and the underlying mechanism of its regulation may be useful to uncover new therapeutics for cancer therapy. The Hippo signaling pathway includes a set of kinases that phosphorylate different proteins in order to phosphorylate and inactivate its main downstream effectors, YAP and TAZ. Thus, modulating phosphorylation and dephosphorylation of the Hippo components by kinases and phosphatases play critical roles in the regulation of the signaling pathway. While information regarding kinase regulation of the Hippo pathway is abundant, the role of phosphatases in regulating this pathway is just beginning to be understood. In this review, we summarize the most recent reports on the interaction of phosphatases and the Hippo pathway in tumorigenesis. We have also introduced challenges in clarifying the role of phosphatases in the Hippo pathway and future direction of crosstalk between phosphatases and the Hippo pathway.

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“…Phosphatases have been considered to be tumor suppressors; however, some of them emerged as having a role in initiating and progression of various types of cancers [34]. LMWPTP influences the phosphorylation of mediators of signaling pathways involved in cancer and, therefore, is postulated to be a tumor-promoting enzyme.…”

Section: Lmwptp As a Signaling Hub In Cancermentioning

confidence: 99%

Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks

Faria

Fonseca

Cordeiro

et al. 2020

Cell. Mol. Life Sci.

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In the past decade, significant progress has been made in understanding the role of protein tyrosine phosphatase as a positive regulator of tumor progression. In this scenario, our group was one of the first to report the involvement of the low molecular weight protein tyrosine phosphatase (LMWPTP or ACP1) in the process of resistance and migration of tumor cells. Later, we and others demonstrated a positive correlation between the amount of this enzyme in human tumors and the poor prognosis. With this information in mind, we asked if LMWPTP contribution to metastasis, would it have an action beyond the primary tumor site. We know that the amount of this enzyme in the tumor cell correlates positively with the ability of cancer cells to interact with platelets, an indication that this enzyme is also important for the survival of these cells in the bloodstream. Here, we discuss several molecular aspects that support the idea of LMWPTP as a signaling hub of cancer hallmarks. Chemical and genetic modulation of LMWPTP proved to shut down signaling pathways associated with cancer aggressiveness. Therefore, advances in the development of LMWPTP inhibitors have great applicability in human diseases such as cancer.

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Protein Tyrosine Phosphatases in Tumor Progression and Metastasis: Promoter or Protection?

Cited by 8 publications

References 109 publications

Gut Microbiota Profile in Patients with Type 1 Diabetes Based on 16S rRNA Gene Sequencing: A Systematic Review

Gut Microbiota Profile in Patients with Type 1 Diabetes Based on 16S rRNA Gene Sequencing: A Systematic Review

Interaction of the Hippo Pathway and Phosphatases in Tumorigenesis

Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks

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