Proteína C-reativa ultra-sensível em pacientes com diagnóstico de doença arterial coronariana estabelecido por angiografia

Síndrome metabólica, aterosclerose e inflamação: tríade indissociável?

“…There is also evidence in the literature of a positive correlation between elevated CRP-us levels and hyperglycemia, hypertension, smoking and presence of MS or abnormal plasma lipid levels. 6,15,[23][24][25] Hyperglycemia is related to inflammation because of formation of advanced glycation end products (AGEs), which can lead to synthesis of IL-6, to activation of macrophages and to oxidative stress, which culminates in production of CRP, contributing to inflammation. Advanced glycation end products are derived from non-enzymatic reaction of glucose (in addition to oxidation of glucose) with proteins, lipids and nucleic acids, leading to oxidative stress and subsequent development of inflammatory and thrombotic processes.…”

“…24,48 Atherosclerosis is a CVD that is characterized by chronic inflammation of the artery wall and consequent formation of plaques, in addition to activation of several different cells of the innate immune system that are directly involved in genesis of deposition of the substances that comprise these plaques, primarily lipids, calcium and inflammatory cells. Atherosclerotic lesions are actually a series of highly specific cellular and molecular responses that are, by their nature, essentially inflammatory.…”

“…It is interesting that the relationship between risk factors has proven to be one of multiplication, and not of simple addition. 24,49 In addition to increasing the risk of hypertension and DM2, the inflammatory process also provokes an increase in cytokine levels, which is directly related to recruitment of monocytes and infiltration of macrophages to the artery wall, with formation of plaques. Since these are slow and asymptomatic processes, the signs can take years to manifest; which is why the use of markers such as CRP-us is an important indicator.…”

“…Presence of hypertension is also related to increased oxidative stress and consequent triggering of the inflammatory process in the walls of blood vessels. 24,29,50 Hyperglycemia and development of DM are related to development of atherosclerosis via different mechanisms. One widely studied mechanism, perhaps the most studied, is that related to AGEs, which are linked with genesis of plaques, but can also accumulate in lesions.…”

Risco cardiovascular em pacientes com doença periodontal

“…Spezzia e Calvoso Júnior, (2013) efetuaram uma pesquisa nas principais bases de dados bibliográficos de estudo, como Pubmed, Scopus, Lilacs, no intuito de investigar a relação entre a doença periodontal, risco cardiovascular e a PCR, onde constataram que a doença periodontal e a doença cardiovascular são bastante prevalentes, dividindo fatores de risco semelhantes, tais como idade, hábito de fumar, estresse, nível socioeconômico, obesidade, entre outros. Outro fato apontado é que pode ocorrer associação entre doença periodontal e doença cardiovascular de diversas formas diferentes, como pelo efeito discreto dos agentes infecciosos presentes no biofilme dentário, participando na formação da placa de ateroma, efeitos indiretos ou mediados pelo hospedeiro acionados pela infecção periodontal, predisposição genética, comum para ambas as doenças e fatores de risco comuns para as duas patologias Lima et al, (2007). realizaram um estudo onde no qual foi avaliada a concentração sérica da PCR de acordo com a grau de severidade da doença cardiovascular apresentada pelo indivíduo, constatando-se que existe uma relação crescente onde pessoas isentas de cardiopatias possuem menores valores da PCR sérica quando em comparação a indivíduos que apresentam doenças cardiovasculares em estágios de maior severidade.…”