1997
DOI: 10.1073/pnas.94.22.11957
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Proteinase inhibitors I and II from potatoes specifically block UV-induced activator protein-1 activation through a pathway that is independent of extracellular signal-regulated kinases, c-Jun N-terminal kinases, and P38 kinase

Abstract: Solar UV irradiation is the causal factor for the increasing incidence of human skin carcinomas. The activation of the transcription factor activator protein-1 (AP-1) has been shown to be responsible for the tumor promoter action of UV light in mammalian cells. We demonstrate that proteinase inhibitor I (Inh I) and II (Inh II) from potato tubers, when applied to mouse epidermal JB6 cells, block UV-induced AP-1 activation. The inhibition appears to be specific for UV-induced signal transduction for AP-1 activat… Show more

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Cited by 63 publications
(55 citation statements)
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“…Participants in the medium intake group did not differ significantly from the lowest intake group in terms of general characteristics or skin cancer risk factors (data not shown). In an experiment using a mouse epidermal cell lines, proteinase inhibitors I and II that were isolated from potatoes were shown to block UV-induced activator protein-1, one of the most important transcription factors in the UV response in mammalian cells (Huang et al, 1997). However, the relevance of this experimental finding to potato consumption at normal levels of intake is unclear.…”
Section: Discussionmentioning
confidence: 88%
“…Participants in the medium intake group did not differ significantly from the lowest intake group in terms of general characteristics or skin cancer risk factors (data not shown). In an experiment using a mouse epidermal cell lines, proteinase inhibitors I and II that were isolated from potatoes were shown to block UV-induced activator protein-1, one of the most important transcription factors in the UV response in mammalian cells (Huang et al, 1997). However, the relevance of this experimental finding to potato consumption at normal levels of intake is unclear.…”
Section: Discussionmentioning
confidence: 88%
“…ously (22,24). Briefly, JB6 C141 cells were starved for 48 h in 0.1% FBS MEM in 37°C, 5% CO 2 atmosphere incubator.…”
Section: Methodsmentioning
confidence: 99%
“…Phosphorylation Analysis for Erk and JNK-Immunoblot analysis for phosphorylated proteins of Erk and JNK was carried out using phospho-specific MAPK antibodies against phosphorylated sites of Erk and JNK as described previously (22,23). Antibodies were from New England Biolabs and used according to the manufacturer's recommendations.…”
Section: Plasmids and Reagents-cmv-neo Vector Plasmid Was Constructedmentioning
confidence: 99%
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