Proteins oxidation and autoantibodies' reactivity against hydrogen peroxide and malondialdehyde -oxidized thyroid antigens in patients' plasmas with Graves' disease and Hashimoto Thyroiditis

Mseddi, Malek; Mansour, Riadh Ben; Gargouri, Bilel; Mnif, F.; Ghawi, Samir El; Hammami, B.; Ghorbel, Abdelmonem; Abid, M.; Lassoued, Saloua

doi:10.1016/j.cbi.2017.04.013

Cited by 11 publications

(10 citation statements)

References 24 publications

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“…Oxidative stress (OS), resulting from an imbalance between the excessive production of reactive oxygen species (ROS) and a reduction in antioxidant production ( 66 ). To date, research on HT and ROS has mainly progressed on two fronts: one is that oxidative stress may lead to the development and exacerbation of HT ( 67 , 68 ); at the same time, some biomarkers of oxidative stress may present a potential diagnostic value ( 69 ); the other is that patients with Hashimoto thyroiditis show enhanced oxidative stress. Many researchers have proven this hypothesis, and they found that some of the oxidative stress markers were elevated, such as serum levels of advanced glycation end products (AGEs), malondialdehyde (MDA) and derived reactive oxygen metabolites (d-ROMs), while many others were decreased, including soluble receptor (sRAGE), serum glutathione (GSH), total antioxidant capacity (TAC) and biological antioxidant potential (BAP) ( 70 – 73 ).…”

Section: Discussionmentioning

confidence: 99%

Emerging trends and hot spots in autoimmune thyroiditis research from 2000 to 2022: A bibliometric analysis

Yang

et al. 2022

Front. Immunol.

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BackgroundAutoimmune thyroiditis (AIT) is the most common autoimmune disease, affecting 3-5% patients worldwide. In recent years, approximately 200 articles on AIT have been published annually in various journals. However, to date, no article has systematically assessed the related literature. Therefore, we conducted a bibliometric analysis on AIT to reveal the dynamic scientific developments and help researchers gain a global perspective while exploring the hotspots and development trends.MethodsAIT-related articles and reviews from 2000 to 2022 were retrieved from the Web of Science Core Collection (WoSCC). The following search terms were used to extract document data: TS= (“ autoimmune thyroiditi*”) OR TI= (“chronic lymphocytic thyroiditi*”) OR TI=(hashimoto*) OR TI= (“postpartum thyroiditis”). We selected articles and reviews published in English from 2000 to 2022. Three software programs (VOSviewer, CiteSpace, Pajek) were employed to analyze the contribution and co-occurrence relationships of different references, countries/regions, institutes, journals and also keywords in this field.ResultsThis scientometric study included 2290 English papers published in 723 journals with 39661 co-cited references from 561 institutions in 120 countries/regions. Based on the reference and keyword analysis, researchers used to focus on “apoptosis”, “insulin resistance”, “encephalopathy”, “IFN-γ” related to AIT during the past 20 years. However, with the development of other novel directions such as “papillary thyroid cancer” (2018-2022), “Vitamin D” (2016-2022), “oxidative stress” (2018-2022), “polymorphism” (2019-2022) and “association” (2020-2022), researchers are more interested in the relationship between papillary thyroid carcinoma and AIT, the effect of vitamin D supplementation on AIT, the oxidative stress in thyroid disease as well as the influence of polymorphism.ConclusionBibliometric analysis of the outputs of AIT shows an overview of the current status of the research on AIT. The associations between papillary thyroid carcinoma, vitamin D, oxidative stress, polymorphism and AIT are major research frontiers. However, further research and collaboration are still required worldwide. Our findings can help researchers grasp the research status of AIT and quickly determine new directions for future research.

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Section: Discussionmentioning

confidence: 99%

Emerging trends and hot spots in autoimmune thyroiditis research from 2000 to 2022: A bibliometric analysis

Yang

et al. 2022

Front. Immunol.

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“…The CAT modification was assessed according to the method of MSEDDI at al. 2017 . Two modifications of the CAT enzyme were assessed by the MDA and the H 2 O 2 .…”

Section: Methodsmentioning

confidence: 99%

“…The CAT modification was assessed according to the method of MSEDDI et al 2017. 7 The optical density (OD) at 405 nm was determined using a micro-ELISA plate reader.…”

Section: Enzyme-linked Immunosorbent Assay (Elisa)mentioning

confidence: 99%

“…Consequently, further the autoimmune reaction, symptoms, and signs, such as weight loss, metabolic abnormalities, fatigue, heat intolerance, decreased appetite and cardiac manifestations, characterize persons with GD . Several studies on animals as well as on human tissues and plasmas provide evidences of an association between oxidative stress and GD . During oxidative stress, reactive oxygen species (ROS) including hydrogen peroxide (H 2 O 2 ), superoxide radical (O 2 −• ) and hydroxyl radical (OH • ) are generated and have inherent chemical properties that confer reactivity to different biological targets such as lipids, proteins, and deoxyribonucleic acid (DNA) .…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress enhances the immune response to oxidatively modified catalase enzyme in patients with Graves’ disease

Gargouri

Mseddi²,

Mnif

et al. 2019

Clinical Laboratory Analysis

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Background Oxidative stress is associated with several autoimmune disorders and oxidative modification of proteins that may result in autoimmune response. This study aims to evaluate the catalase (CAT) activity and the autoimmune response against the native CAT and the oxidatively modified enzyme in patients with Graves' disease (GD) and healthy controls in a comparative way. Methods The CAT activity was evaluated via spectrophotometric method. Using enzyme‐linked immunosorbent assay, the reactivities of autoantibody toward native, malondialdehyde (MDA) and hydrogen peroxide (H2O2) modified CAT were evaluated in plasmas of patients and controls. Results Reduced CAT activity was found in patients compared with controls (P < .05). It was proved that levels of IgG antibodies against MDA‐modified CAT were higher than against unmodified ones (P < .001). No changes were found for the reactivities to H2O2‐modified CAT. Positive correlation was found between the reactivity to MDA‐modified CAT and the triiodothyronine level (P < .001, r = .6). Conclusion Our findings incriminate the MDA in the autoantibodies reactivity to oxidatively modified CAT leading to a disturbed oxidative profile and/or the progression of GD pathology.

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“…Hashimoto’s thyroiditis (HT) is an autoimmune condition arising from an abnormal immune response to thyroid antigens ( 1 ). Although the exact mechanism (s) of induction and maintenance of thyroid autoimmunity is not fully understood, oxidative stress and mitochondrial dysfunction are involved in the pathogenesis of autoimmune thyroid disorders including HT ( 2 – 4 ). Current research also identify a link between altered thyroid state (such as hypo- and hyperthyroidism), thyroid hormones and mitochondrial oxidative stress ( 5 – 7 ).…”

Section: Introductionmentioning

confidence: 99%

Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis

Esfahanian

Hazaveh

Garehbagh

et al. 2021

ijph

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Background: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC). Methods: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto’s thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018. Results: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group. Conclusion: These data suggest the possible involvement of mitochondria and oxidative stress in the pathophysiology of HT.

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Proteins oxidation and autoantibodies' reactivity against hydrogen peroxide and malondialdehyde -oxidized thyroid antigens in patients' plasmas with Graves' disease and Hashimoto Thyroiditis

Cited by 11 publications

References 24 publications

Emerging trends and hot spots in autoimmune thyroiditis research from 2000 to 2022: A bibliometric analysis

Emerging trends and hot spots in autoimmune thyroiditis research from 2000 to 2022: A bibliometric analysis

Oxidative stress enhances the immune response to oxidatively modified catalase enzyme in patients with Graves’ disease

Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis

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