Proteins, platelets, and blood coagulation at biomaterial interfaces

Xu, Li Chong; Bauer, James W.; Siedlecki, Christopher A.

doi:10.1016/j.colsurfb.2014.09.040

Cited by 325 publications

(305 citation statements)

References 219 publications

(255 reference statements)

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“…Creating a submicron-textured surface can dramatically reduce the accessible contact area for platelets or bacteria to interact with the surface, thereby minimizing the opportunities for bacteria and platelet adsorption. 102–104 Polymers that combine multiple functional groups on one surface have also been tested, such as combining synthetic heparin-mimetic polymer or hydrophilic polymer brushes (e.g., PEG) with antibacterial quaternary compounds (QAC) or Ag nanoparticles. 105–107 …”

Section: Creating Dual-functionality Hemocompatible Surfacesmentioning

confidence: 99%

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

et al. 2016

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Biomedical devices are essential for patient diagnosis and treatment; however, when blood comes in contact with foreign surfaces or homeostasis is disrupted, complications including thrombus formation and bacterial infections can interrupt device functionality, causing false readings and/or shorten device lifetime. Here, we review some of the current approaches for developing antithrombotic and antibacterial materials for biomedical applications. Special emphasis is given to materials that release or generate low levels of nitric oxide (NO). Nitric oxide is an endogenous gas molecule that can inhibit platelet activation as well as bacterial proliferation and adhesion. Various NO delivery vehicles have been developed to improve NO’s therapeutic potential. In this review, we provide a summary of the NO releasing and NO generating polymeric materials developed to date, with a focus on the chemistry of different NO donors, the polymer preparation processes, and in vitro and in vivo applications of the two most promising types of NO donors studied thus far, N-diazeniumdiolates (NONOates) and S-nitrosothiols (RSNOs).

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Section: Creating Dual-functionality Hemocompatible Surfacesmentioning

confidence: 99%

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

et al. 2016

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“…The chemistry of the implant surface as well as its physicochemical properties such as wettability or surface energy, and surface topography were found to be important factors that dictate protein adsorption, and platelet adhesion and activation [9][10][11][12] . Regulation of platelet adhesion onto the surface of a blood contacting implant is a key aspect in the field of biomedicine and tissue engineering [13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Extreme Wettability on Platelet Adhesion on Metallic Implants: From Superhydrophilicity to Superhydrophobicity

Moradi

Hadjesfandiari

Toosi

et al. 2016

ACS Appl. Mater. Interfaces

100

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In order to design antithrombotic implants, the effect of extreme wettability (superhydrophilicity to superhydrophobicity) on the biocompatibility of the metallic substrates (stainless steel and titanium) was investigated. The wettability of the surface was altered by chemical treatments and laser ablation methods. The chemical treatments generated different functionality groups and chemical composition as evident from XPS analysis. The micro/nanopatterning by laser ablation resulted in three different pattern geometry and different surface roughness and consequently wettability. The patterned surface were further modified with chemical treatments to generate a wide range of surface wettability. The influence of chemical functional groups, pattern geometry, and surface wettability on protein adsorption and platelet adhesion was studied. On chemically treated flat surfaces, the type of hydrophilic treatment was shown to be a contributing factor that determines the platelet adhesion, since the hydrophilic oxidized substrates exhibit less platelet adhesion in comparison to the control untreated or acid treated surfaces. Also, the surface morphology, surface roughness, and superhydrophobic character of the surfaces are contributing factors to platelet adhesion on the surface. Our results show that superhydrophobic cauliflower-like patterns are highly resistant to platelet adhesion possibly due to the stability of Cassie-Baxter state for this pattern compared to others. Our results also show that simple surface treatments on metals offer a novel way to improve the hemocompatibility of metallic substrates.

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“…This could be detrimental for the thrombogenicity of the nanostructured surfaces. However, some authors [3] suggested that not only the total amount of adsorbed FBG, but also its conformation can influence the thrombogenicity of a surface by exposing platelet-binding sites. All treated surfaces displayed a higher adsorbed albumin to fibrinogen ratio than the untreated samples.…”

Section: Resultsmentioning

confidence: 99%

“…Changes in the surface topography also influence protein adsorption. There seems to be no general trend in the effect of textured surfaces on the amount of adsorbed protein [3]. Competitive adsorption tests revealed that, despite the limiting effect exerted by FBG on the adsorption of HSA, treated surfaces have a higher adsorbed HSA/FBG ratio, indicating lower thrombogenicity.…”

Section: Discussionmentioning

confidence: 99%

“…Besides its chemical composition, physical properties such as surface roughness, topography and wettability will determine the biological response of the host organism. Modifying the surface topography of a material can affect the adsorption of different proteins from the blood flow and, as a result, encourage or inhibit platelets adhesion and activation [3]. …”

Section: Introductionmentioning

confidence: 99%

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Surface Nanostructuring of Parylene-C Coatings for Blood Contacting Implants

et al. 2018

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This paper investigates the effects on the blood compatibility of surface nanostructuring of Parylene-C coating. The proposed technique, based on the consecutive use of O2 and SF6 plasma, alters the surface roughness and enhances the intrinsic hydrophobicity of Parylene-C. The degree of hydrophobicity of the prepared surface can be precisely controlled by opportunely adjusting the plasma exposure times. Static contact angle measurements, performed on treated Parylene-C, showed a maximum contact angle of 158°. The nanostructured Parylene-C retained its hydrophobicity up to 45 days, when stored in a dry environment. Storing the samples in a body-mimicking solution caused the contact angle to progressively decrease. However, at the end of the measurement, the plasma treated surfaces still exhibited a higher hydrophobicity than the untreated counterparts. The proposed treatment improved the performance of the polymer as a water diffusion barrier in a body simulating environment. Modifying the nanotopography of the polymer influences the adsorption of different blood plasma proteins. The adsorption of albumin—a platelet adhesion inhibitor—and of fibrinogen—a platelet adhesion promoter—was studied by fluorescence microscopy. The adsorption capacity increased monotonically with increasing hydrophobicity for both studied proteins. The effect on albumin adsorption was considerably higher than on fibrinogen. Study of the proteins simultaneous adsorption showed that the albumin to fibrinogen adsorbed ratio increases with substrate hydrophobicity, suggesting lower thrombogenicity of the nanostructured surfaces. Animal experiments proved that the treated surfaces did not trigger any blood clot or thrombus formation when directly exposed to the arterial blood flow. The findings above, together with the exceptional mechanical and insulation properties of Parylene-C, support its use for packaging implants chronically exposed to the blood flow.

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Proteins, platelets, and blood coagulation at biomaterial interfaces

Cited by 325 publications

References 219 publications

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

Effect of Extreme Wettability on Platelet Adhesion on Metallic Implants: From Superhydrophilicity to Superhydrophobicity

Surface Nanostructuring of Parylene-C Coatings for Blood Contacting Implants

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