Proteinsynthese und Ikterus bei der ANIT-Cholestase der Ratte

Richter, Elmar; Grün, M; Kühn, H.

doi:10.1007/978-3-642-47085-1_85

Cited by 6 publications

(2 citation statements)

References 1 publication

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“…An increased protein synthesis rate in experimentally induced cholestasis in rats has been found [9]. I n a preliminary study, we recorded a similar phenomenon in human liver tissue [35].…”

Section: Discussionmentioning

confidence: 67%

Rate of in vitro Incorporation of Precursors into Hepatic Lipids and Proteins in Patients with Extrahepatic Cholestasis

Stakeberg

Lundborg

Scherstén

1974

Eur J Clin Investigation

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Extrahepatic cholesbsis in man is known to be associated with high phosphoglyceride and cholesterol concentrations in serum. Moreover, an abnormal lipoprotein, often referred to as lipoprotein-X (LP-X), appears in serum in cases of extrahepatic cholesbsis.The purpose of this study was to determine the rate of incorporation of precursors into hepatic lipids and proteina in uitro and to compare these changes with the lipoproteins in plasma in patients with extrahepatic cholestasis. The rate of incorporation of glycerol into triglycerides and into different classes of phosphoglycerides was determined. The rate of incorporation of leucine into proteins was also determined in liver slices from 16 patients with extrahepatic cholestasis and compared with controls. In cholestatic liver tissue, the rate of incorporation of glycerol into choline phosphoglycerides and into ethanolamine phosphoglycerides was significantly increased. The rate of incorporation of leucine into hepatic proteins was also increaaed significantly in these patients. The results suggest that the changed metabolism of phospholipids and protein in liver tissue in cholestatic conditions may contribute to the changes in the serum lipoprotein pattern.

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“…An increased protein synthesis rate in experimentally induced cholestasis in rats has been found [9]. I n a preliminary study, we recorded a similar phenomenon in human liver tissue [35].…”

Section: Discussionmentioning

confidence: 67%

Rate of in vitro Incorporation of Precursors into Hepatic Lipids and Proteins in Patients with Extrahepatic Cholestasis

Stakeberg

Lundborg

Scherstén

1974

Eur J Clin Investigation

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“…Richter et al [34] also employed drug-induced cholangitis in rats which results in intrahepatic cholestasis. This condition caused in creased amino acid uptake in liver slices.…”

Section: Discussionmentioning

confidence: 99%

Amino Acid Incorporation into Liver Proteins during Extrahepatic Cholestasis in the Rat

Lundborg¹,

Hamberger²

1974

Eur Surg Res

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Extrahepatic cholestasis was induced in rats by ligation of the bile duct. L-(4,5-³H)-leucine or L-(U-¹⁴C)-leucine were incorporated into the proteins of control and cholestatic liver slices by incubation in balanced salt media. The cholestatic liver showed a rate of amino acid incorporation which was approximately three times that of control liver. There was no apparent effect on the specific radioactivity of the precursor. The distribution of protein-bound radioactivity among sub-cellular fractions was studied. The radioactivity increased in all the main fractions, and the largest increase was seen in the soluble proteins. Serum from control or cholestatic animals and bile from control animals added during incubation of liver slices had small effect on the incorporation of leucine. Leucine incorporation was not appreciably altered in other organs.

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Lipid composition in jaundiced rat liver by radio-thin-layer chromatography and photodensitometry

Greco

Mingrone

Agnes

et al. 1982

Experimental pathology

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Proteinsynthese und Ikterus bei der ANIT-Cholestase der Ratte

Cited by 6 publications

References 1 publication

Rate of in vitro Incorporation of Precursors into Hepatic Lipids and Proteins in Patients with Extrahepatic Cholestasis

Rate of in vitro Incorporation of Precursors into Hepatic Lipids and Proteins in Patients with Extrahepatic Cholestasis

Amino Acid Incorporation into Liver Proteins during Extrahepatic Cholestasis in the Rat

Lipid composition in jaundiced rat liver by radio-thin-layer chromatography and photodensitometry

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