Proteobionics:  Biomimetics in Proteomics

Sommer, and Andrei P.; Gheorghiu, E.

doi:10.1021/pr050370s

Cited by 3 publications

(2 citation statements)

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“…It is believed that the elastic fibers play an important role in maintaining skin elasticity. 22 On the basis of the simple physicochemical picture (condensed in Figure 3) on the one hand, and ample experimental evidence on the tunability of interfacial water layers by visible lightboth on hydrophobic and hydrophilic surfaces [6][7][8] on the other hand, we designed a program to restore elastin maturation in vivo. For this one of us irradiated the skin around the corner of the eyes with light delivered by an array of LEDs (WARP 10, Quantum Devices, Inc. WI).…”

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From Microtornadoes to Facial Rejuvenation: Implication of Interfacial Water Layers

Sommer

Zhu

2008

Crystal Growth & Design

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Crystalline interfacial water layers have been observed at room temperature on both hydrophobic and hydrophilic surfaces -in air and subaquatically. Their implication in biology (and evolution) was postulated in a visionary paper in 1971 by Szent Györgyi. Today, they are believed to play a fundamental role in protein folding. A recent X-ray diffraction study reports on their presence on crystals in contact with their growth solution. Their subaquatic persistence on hydrophobic solids was reported in 2007. Their relevance in nanoscale phenomena is reflected by the multidisciplinary focus in their study. In the course of a systematic exploration of interfacial water layers on solids we discovered microtornadoes, found a complementary explanation to the surface conductivity on hydrogenated diamond, and arrived at a practical method to repair elastin degeneration using light. The result was rejuvenated skin, reduced wrinkle levels, juvenile complexion, and lasting resilience.Conforming to an extreme sensibility of interfacial water layers to direct observation techniques, a major part of the existing data stems from computer models. Experimentally, interfacial water layers have been studied by X-rays and neutron scattering, 1,2 atomic force microscopy (AFM), 3-5 near-field scanning optical microscopy (NSOM), 6 atomic force acoustic microscopy (AFAM), 7 drop evaporation experiments, 8 and recently on hydrogen-terminated nanocrystalline diamond. 9 A synoptic analysis of all these perspectives provides an increasingly clear picture of the nature of interfacial water: The central and probably generalizable result seems to be that the structural difference between water layers on a solid surface exposed to air, and water layers that prevail at the interface between the same solid surface and bulk water, is less pronounced than that between water layers on a hydrophobic and a hydrophilic surface, studied under identical conditions. The practical importance of this insight is enormous: Extracting information on water structures in air is simpler than probing water layers at the interface between a solid and bulk water, and we are justified to use the structural information (molecular order, density, or viscosity of the water) acquired in simple systems for modeling complex systems. In practice, this means that structural information obtained for instance by AFM in air on a certain model substrate could be transferred for modeling partial aspects in biological systems. The relevance of the "partial aspect" approach becomes clear from realizing that biological surfaces are inhomogeneous: Their dynamic nature, with nanoscopic patches varying in polarity and topography, exclude a macroscopic perspective and complicate distinctive experimental insight. Thus, the requirement for model surfaces, which permit us to mimic specific biosystem aspects, is clear. Obviously, biocompatible materials based model surfaces are the best choice here. The themes investigated have one aspect in common: The substrates impose their orde...

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“…Whereas decreased skin elasticity is considered as a factor that promotes wrinkle formation, the relationship between decreased skin elasticity and wrinkle formation is not fully understood. It is believed that the elastic fibers play an important role in maintaining skin elasticity …”

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From Microtornadoes to Facial Rejuvenation: Implication of Interfacial Water Layers

Sommer

Zhu

2008

Crystal Growth & Design

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The Role of Nanobacteria/Calcifying Nanoparticles in Prostate Disease

Jones

Çiftçioğlu

McKay

2008

Chronic Prostatitis/Chronic Pelvic Pain Syndrome

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Antiinfectives and Low-Level Light: A New Chapter in Photomedicine

Sommer

2007

Photomedicine and Laser Surgery

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Low-level light (LLL) therapy is compatible with antiinfectives, and even capable of boosting effects of superficially applied and/or absorbed antiinfectives. Temporal coordination between light treatment and drug administration maximizes drug effects and minimizes possible adverse effects. Irradiation should start when the drug concentration has reached its maximum in the desired field of action. Light-induced flow in nanoscale cavities could represent one mechanism of LLL therapy.

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Proteobionics: Biomimetics in Proteomics

Cited by 3 publications

References 58 publications

From Microtornadoes to Facial Rejuvenation: Implication of Interfacial Water Layers

From Microtornadoes to Facial Rejuvenation: Implication of Interfacial Water Layers

The Role of Nanobacteria/Calcifying Nanoparticles in Prostate Disease

Antiinfectives and Low-Level Light: A New Chapter in Photomedicine

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