Proteoglycans as miscommunication biomarkers for cancer diagnosis

Xu, Lingling; Tang, Liang; Zhang, Lijuan

doi:10.1016/bs.pmbts.2018.12.003

Cited by 11 publications

(8 citation statements)

References 207 publications

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“…Several interesting results from our study may promote further investigation into the functions and partners of miR-200s, push forward the clinical application of miR-200s and also provide us with more targets and strategies for therapy. Although not perfect, most of the findings from our results have been successfully confirmed by recent experimental literatures [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51]. To better confirm the predictive power of our approach and understand the mechanisms underlying the initiation and progression of CRC, more large-scale and standard investigations are worth conducting.…”

Section: Discussionsupporting

confidence: 70%

“…7 The FOXO signaling pathway enriched in KEGG. Objects with pentagrams are acting locus by mapped genes and growth and metastatic properties of cancerous cells [34]. Accumulating evidence indicates that proteoglycans have a significant impact on the behavior of cancer cells and the microenvironment during the progression of carcinogenesis and may serve as attractive pharmacological targets in cancer immunotherapy [35].…”

Section: Discussionmentioning

confidence: 99%

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Integrated characterization and validation of the prognostic significance of microRNA-200s in colorectal cancer

Peng

Cheng

et al. 2020

Cancer Cell Int

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Background: Accumulating evidence has demonstrated that could serve as promising molecular biomarkers for cancer prognosis. Nevertheless, the associations between miR-200s expression and colorectal cancer (CRC) prognosis remain controversial. Methods:We applied two mainstream approaches combining meta-analysis and bioinformatics analysis to answer whether miR-200s were associated with the prognosis of CRC patients and why miR-200s could be used as prognostic biomarkers for CRC. Results:Consequently, low expression of miR-200s was associated with unfavorable overall survival (OS) in CRC patients (HR: 1.09; 95% CI 1.01-1.17; P = 0.025). According to the subgroup analysis, the prognostic role of miR-200s was more significant for tissue samples, large samples, American patients and miR-200a subgroups. Then the target genes of miR-200s were predicted and applied for functional enrichment analyses. The results showed that the target genes of miR-200s were mainly enriched into some vital ontology subjects such as regulation ability, key cell structures and binding function. Moreover, a series of important signaling pathways were identified, which were significantly linked with the initiation and progression of CRC. Additionally, a protein-protein interaction (PPI) network of miR-200s targets was constructed to screen hub genes and modules. The identified hub genes and modules were validated to be highly involved in the occurrence and development of CRC.Conclusions: Current evidences revealed that miR-200s could be promising biomarkers for CRC prognosis. However, the findings still need to be validated with more larger-scale prospective studies and biological experiments before miR-200s could be applied into clinical application.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Integrated characterization and validation of the prognostic significance of microRNA-200s in colorectal cancer

Peng

Cheng

et al. 2020

Cancer Cell Int

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“…Based on the core protein and GAG chain properties, proteoglycans are classified into one of three groups, including small leucine-rich proteoglycans (SLRPs), modular proteoglycans, and cell-surface proteoglycans [ 90 ]. Overall, these unique variants have roles in ECM communication, tumor angiogenesis, progression, and metastasis [ 96 , 97 ].…”

Section: Ecm Components and Their Function In Osmentioning

confidence: 99%

The role of extracelluar matrix in osteosarcoma progression and metastasis

Cui

Dean

Hornicek

et al. 2020

J Exp Clin Cancer Res

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Osteosarcoma (OS) is the most common primary bone malignancy and responsible for considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although neoadjuvant chemotherapy has improved 5-year survival rates for patients with localized OS from 20% to over 65%, outcomes for those with metastasis remain dismal. In addition, therapeutic regimens have not significantly improved patient outcomes over the past four decades, and metastases remains a primary cause of death and obstacle in curative therapy. These limitations in care have given rise to numerous works focused on mechanisms and novel targets of OS pathogenesis, including tumor niche factors. OS is notable for its hallmark production of rich extracellular matrix (ECM) of osteoid that goes beyond simple physiological growth support. The aberrant signaling and structural components of the ECM are rich promoters of OS development, and very recent works have shown the specific pathogenic phenotypes induced by these macromolecules. Here we summarize the current developments outlining how the ECM contributes to OS progression and metastasis with supporting mechanisms. We also illustrate the potential of tumorigenic ECM elements as prognostic biomarkers and therapeutic targets in the evolving clinical management of OS.

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“…These mechanisms ultimately control phenotypes that, in disease, can culminate in physical and mental disabilities in mucopolysaccharidosis ( 4 ), jeopardize wound healing ( 25 ), promote cancer ( 26 ), lead to respiratory failure ( 3 ), or enable binding of viruses such as SARS-CoV-2 ( 10 ). GAGs have therefore been proposed as potential biomarkers for these different diseases ( 4, 27, 28 ). We and others have demonstrated the added advantage of measuring GAGs non-invasively, for example in blood and urine ( 5–8, 29 ).…”

Section: Discussionmentioning

confidence: 99%

Analytical Performance of a Standardized Kit for Mass Spectrometry-based Measurements of Human Glycosaminoglycans

Tamburro¹,

Bratulić

Shameh³

et al. 2021

Preprint

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Glycosaminoglycans (GAGs) are long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections, thereby serving as potential biomarkers. A successful clinical translation of GAGs as biomarkers depends on the availability of standardized GAG measurements. However, owing to the analytical complexity associated with the quantification of GAG concentration and structural composition, a standardized method to simultaneously measure multiple GAGs is missing. In this study, we sought to characterize the analytical performance of a liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (LC-MS/MS)-based kit for the quantification of 17 GAG disaccharides. The kit showed acceptable linearity, selectivity and specificity, accuracy and precision, and analyte stability in the absolute quantification of 15 GAG disaccharides. In native human samples, here using urine as a reference matrix, the analytical performance of the kit was acceptable for the quantification of CS disaccharides. Intra- and inter-laboratory tests performed in an external laboratory demonstrated robust reproducibility of GAG measurements showing that the kit was acceptably standardized. In conclusion, these results indicated that the LC-MS/MS kit was standardized for the simultaneous measurement of GAG disaccharides allowing for comparability of measurements and enabling translational research.

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Proteoglycans as miscommunication biomarkers for cancer diagnosis

Cited by 11 publications

References 207 publications

Integrated characterization and validation of the prognostic significance of microRNA-200s in colorectal cancer

Integrated characterization and validation of the prognostic significance of microRNA-200s in colorectal cancer

The role of extracelluar matrix in osteosarcoma progression and metastasis

Analytical Performance of a Standardized Kit for Mass Spectrometry-based Measurements of Human Glycosaminoglycans

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