Proteolipid Protein Gene Product Can Be Secreted and Exhibit Biological Activity during Early Development

Yamada, Masahisa; Ivanova, Anna; Yamaguchi, Yoshihide; Lees, Marjorie B.; Ikenaka, Kazuhiro

doi:10.1523/jneurosci.19-06-02143.1999

Cited by 41 publications

(27 citation statements)

References 40 publications

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“…Support for this hypothesis may be implied from studies on a newly identified PLP-related protein that has an altered N terminus and different subcellular localization (Bongarzone et al, 1999). Alternatively, the protein produced at these very early stages could be the secreted PLP fragment described by Yamada et al (1999), which has been proposed to increase the number of oligodendrocytes in mixed glial cultures. Thus, novel PLP-related proteins may be expressed well before active myelination and could have functions quite different from the classic PLP/DM20.…”

Section: Plp/dm20 Protein Expression In Neonatal Cortexmentioning

confidence: 99%

Proteolipid Promoter Activity Distinguishes Two Populations of NG2-Positive Cells throughout Neonatal Cortical Development

et al. 2002

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Transgenic mice expressing enhanced green fluorescent protein (EGFP) driven by the mouse myelin proteolipid protein (PLP) gene promoter have been developed to investigate cells in the oligodendrocyte lineage. Transgene expression is consistent with the developmental expression of PLP, with cells at all stages of oligodendrocyte differentiation clearly visualized. These animals were analyzed to establish the time course of oligodendrocyte progenitor migration, proliferation, and differentiation in neonatal cortex. In these animals, two populations of NG2 proteoglycan-positive oligodendrocyte progenitor cells were identified that exist in postnatal subventricular zone and cortex. These two populations are distinguished by the presence or absence of PLP gene expression. Thus, PLP gene expression defines a subpopulation of NG2-positive cells from very early postnatal ages, which migrates toward the pial surface and proliferates in situ. EGFP ϩ /NG2 ϩ cells are present in the cortex from postnatal day 1, and they remain in the cortex as undifferentiated oligodendrocyte progenitors for up to 3 weeks before myelination begins. These data could be explained by the presence of an important inhibitor of oligodendrocyte differentiation in the cortex during this period, which is downregulated in a region-specific manner to allow myelination. On the other hand, it is possible that oligodendrocyte progenitor cells remain undifferentiated in cortex until an essential signal is produced in situ to induce differentiation.

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Section: Plp/dm20 Protein Expression In Neonatal Cortexmentioning

confidence: 99%

Proteolipid Promoter Activity Distinguishes Two Populations of NG2-Positive Cells throughout Neonatal Cortical Development

et al. 2002

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“…Dissociated glial cells were prepared as described before (Yamada et al, 1999). Plated glial cells were allowed to grow for a 14 days, and processed for siRNA treatments.…”

Section: Mouse Astrocytes Primary Culturementioning

confidence: 99%

BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood–brain-barrier

Araya

Kudo

Kawano

et al. 2008

Molecular and Cellular Neuroscience

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Bone morphogenetic protein (BMP) signaling is involved in differentiation of neural precursor cells into astrocytes, but its contribution to angiogenesis is not well characterized. This study examines the role of BMP signaling through BMP type IA receptor (BMPRIA) in early neural development using a conditional knockout mouse model, in which Bmpr1a is selectively disrupted in telencephalic neural stem cells. The conditional mutant mice show a significant increase in the number of cerebral blood vessels and the level of vascular endothelial growth factor (VEGF) is significantly upregulated in the mutant astrocytes. The mutant mice also show leakage of immunoglobulin around cerebral microvessels in neonatal mice, suggesting a defect in formation of the blood-brain-barrier. In addition, astrocytic endfeet fail to encircle cortical blood vessels in the mutant mice. These results suggest that BMPRIA signaling in astrocytes regulates the expression of VEGF for proper cerebrovascular angiogenesis and has a role on in the formation of the blood-brain-barrier.

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“…The chemokine GRO-1, the transcription of which is upregulated in response to insult, might also be a regulator of oligodendrocyte progenitor proliferation in the postnatal mouse [Wu et al, 2000]. In addition, a secreted proteolipid gene product has been suggested to exert proliferative activity on oligodendrocytes [Yamada et al, 1999].…”

Section: Proliferation and Migration Of Oligodendroglial Cells From Vmentioning

confidence: 99%

The Early Steps of Oligodendrogenesis: Insights from the Study of the plp Lineage in the Brain of Chicks and Rodents

et al. 2001

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Oligodendrocytes are the myelin-forming cells of the central nervous system. Over the last decade, their development in the embryonic brain and spinal cord has been documented following the discovery of early oligodendroglial markers. These early expressed oligodendroglial genes nevertheless show differences in their spatiotemporal pattern of expression and it is not yet clear if their expression is linked in a linear way. This review highlights the common themes underlying the spatiotemporal aspects of oligodendrogenesis in chick and rodent brain and discusses some recent advances in the knowledge of the cell lineage expressing plp, one of the early oligodendroglial genes. We suggest a model of oligodendroglial commitment whereby definitive oligodendroglial progenitor formation is preceded by a primitive neuroglial progenitor stage and whereby different oligodendrocyte lineages might segregate from either plp-positive or plp-negative primitive progenitor cells.

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Proteolipid Protein Gene Product Can Be Secreted and Exhibit Biological Activity during Early Development

Cited by 41 publications

References 40 publications

Proteolipid Promoter Activity Distinguishes Two Populations of NG2-Positive Cells throughout Neonatal Cortical Development

Proteolipid Promoter Activity Distinguishes Two Populations of NG2-Positive Cells throughout Neonatal Cortical Development

BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood–brain-barrier

The Early Steps of Oligodendrogenesis: Insights from the Study of the plp Lineage in the Brain of Chicks and Rodents

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