2019
DOI: 10.1590/0074-02760180556
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Proteomic analysis of excretory-secretory products from young adults of Angiostrongylus cantonensis

Abstract: BACKGROUND Angiostrongyliasis is caused by the nematode Angiostrongylus cantonensis and can lead to eosinophilic meningitis and meningoencephalitis in humans. The young adult worms play central pathogenic roles in the central nervous system (CNS); however, the underlying mechanism is unclear. Excretory-secretory products (ESPs) are good investigation targets for studying the relationship between a host and its parasite. OBJECTIVES We aimed to … Show more

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Cited by 19 publications
(20 citation statements)
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“…Aspartyl protease inhibitor, cathepsin B-like cysteine proteinase, haemoglobinase-type cysteine proteinase, and heat shock protein 70 have been detected in ESPs [53]. On the other hand, our study identified approximately 51 protein spots and found immunoreactivity for protein disulfide-isomerase, a putative aspartic protease, and annexin in A. cantonensis L5 [33]. Here, we found that the ESPs of A. cantonensis L5 can stimulate the ER stress generation and the Ca 2+ concentration in activated astrocytes.…”
Section: Discussionmentioning
confidence: 48%
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“…Aspartyl protease inhibitor, cathepsin B-like cysteine proteinase, haemoglobinase-type cysteine proteinase, and heat shock protein 70 have been detected in ESPs [53]. On the other hand, our study identified approximately 51 protein spots and found immunoreactivity for protein disulfide-isomerase, a putative aspartic protease, and annexin in A. cantonensis L5 [33]. Here, we found that the ESPs of A. cantonensis L5 can stimulate the ER stress generation and the Ca 2+ concentration in activated astrocytes.…”
Section: Discussionmentioning
confidence: 48%
“…Afterwards, L3 develop into fifth-stage larvae (L5) and remain in the CNS of the host indefinitely. In this condition, eosinophilic meningitis and eosinophilic meningoencephalitis can be induced in the brain of the host [33]. In our histopathological study, we found that L5 were surrounded by eosinophils in the anterior cerebral fissure, hippocampus, posterior cerebral fissure, and cerebellar fissure on day 14 post-infection [43].…”
Section: Discussionmentioning
confidence: 63%
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“…Among them, 29 proteins were identified as cytoskeleton-related proteins and functional proteins [ 222 ]. The latest study aimed to identify and characterize the excretory-secretory protein profile of A. cantonensis adult larvae [ 223 ]. A total of 51 spots were identified using 2-DE.…”
Section: Discovery Approach—description Of the Selected Fbps And Tmentioning
confidence: 99%
“…Then, approximately 254 proteins were identified by LC-MS/MS and further classified according to their biological functions. Finally, in the pool of excretory-secretory products of A. cantonensis the immunoreactive proteins were identified, including proteins like, disulphide isomerase, putative aspartic protease or annexin [ 223 ].…”
Section: Discovery Approach—description Of the Selected Fbps And Tmentioning
confidence: 99%