Proteomic analysis of the earthworm <i>Eisenia fetida</i> exposed to oxytetracycline in soil

Zhao, Huabing; Shi, Sanyuan; Zhao, Hong; Guo, Jin; Yang, Zhen; Gao, Hongsheng; Lu, Fuping

doi:10.1039/c9ra06004a

Cited by 11 publications

(4 citation statements)

References 37 publications

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“…Therefore, it is necessary to continue developing practices management that reduces the potential risks associated with these highly toxic compounds (Bai and Ogbourne, 2016). The terrestrial ecosystems' contamination occurs because this compound's residues continue to be discharged into the soil through sewage irrigation and contaminated manure (Zhao et al, 2019). This compound is an antiparasitic widely used in livestock; animals excrete it through manure and negatively affect the survival and reproduction of organisms that degrade manure, such as dung beetles and entomopathogenic nematodes (González-Tokman et al, 2017;Villada-Bedoya et al, 2021).…”

Section: Toxicity To Terrestrial Organismsmentioning

confidence: 99%

“…This compound is an antiparasitic widely used in livestock; animals excrete it through manure and negatively affect the survival and reproduction of organisms that degrade manure, such as dung beetles and entomopathogenic nematodes (González-Tokman et al, 2017;Villada-Bedoya et al, 2021). Ivermectin affects the survival of Pristionchus maupasi (Kar et al, 2020), Eisenia fétida (Zhao et al, 2019), Folsomia candida (Guimarães et al, 2019), Hypoaspis aculeifer (Römbke et al, 2010), Thorectes lusitanicus (Verdú et al, 2020), Sepsis punctum (Conforti et al, 2018), Enchytraeus crypticus, Folsomia fimetaria, Hypogastrura assimilis (Jensen and Scott-Fordsmand, 2012), among others.…”

Section: Toxicity To Terrestrial Organismsmentioning

confidence: 99%

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Environmental and ecotoxicological effects of drugs used for the treatment of COVID 19

Chacca

Maldonado²,

Vilca³

2022

Front. Environ. Sci.

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Consumption of different pharmaceuticals has increased since the COVID-19 pandemic. Some health institutions worldwide approved the use of drugs such as ivermectin, hydroxychloroquine, azithromycin, dexamethasone, favipiravir, remdesivir, lopinavir-ritonavir, chloroquine, dexamethasone for the treatment of the virus. Once consumed by humans, these compounds are released in urine and faeces, ending up in wastewater and conducted to treatment plants or directly discharged without prior treatment into surface water and soil, with minimum values recorded between 7 ng/L and < 0.08 μg/L for azithromycin and ivermectin respectively, as well as dexamethasone with 0.73 ng/L in surface water and an average of 50–60 ng/L for favipiravir. Their presence has numerous toxicological effects on aquatic and terrestrial species, influencing population decline and altering the growth of organisms. However, the environmental consequences of pharmaceuticals in the environment are poorly known, especially for antivirals studied in this article. This work aims to analyze the presence, treatment and ecotoxicity of drugs used in the pandemic COVID 19, mainly focusing on aquatic and terrestrial ecosystems since that is where they arrive through wastewater. Ecotoxicological effects on flora, fauna and humans are also analyzed. Once there, they persist in the environment causing severe ecological damage, developmental and growth disorders in animals and plants and, in many cases, even the death of species.

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Section: Toxicity To Terrestrial Organismsmentioning

confidence: 99%

Section: Toxicity To Terrestrial Organismsmentioning

confidence: 99%

Environmental and ecotoxicological effects of drugs used for the treatment of COVID 19

Chacca

Maldonado²,

Vilca³

2022

Front. Environ. Sci.

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“…They are identified as the key species of invertebrates, which can indicate soil health and feedback contamination of terrestrial ecosystems . The earthworm species, Eisenia fetida and Eisenia andrei, were usually suggested as the model organism for sensitive diagnosis of soil contamination . Earthworm activities such as burrowing, feeding, digestion, and excretion, often contributed to the removal of pollutants .…”

Section: Introductionmentioning

confidence: 99%

“…13 The earthworm species, Eisenia fetida and Eisenia andrei, were usually suggested as the model organism for sensitive diagnosis of soil contamination. 14 Earthworm activities such as burrowing, feeding, digestion, and excretion, often contributed to the removal of pollutants. 15 affect the composition of the metabolites.…”

Section: Introductionmentioning

confidence: 99%

Co-exposure of Monensin Increased the Risks of Atrazine to Earthworms

Jiang

Zhai

Liu

et al. 2022

Environ. Sci. Technol.

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Antibiotics could enter farmlands through sewage irrigation or manure application, causing combined pollution with pesticides. Antibiotics may affect the environmental fate of pesticides and even increase their bioavailability. In this study, the influence of monensin on the degradation, toxicity, and availability of atrazine in soil-earthworm microcosms was investigated. Monensin inhibited the degradation of atrazine, changed the metabolite patterns in soil, and increased the bioavailability of atrazine in earthworms. Atrazine and monensin had a significant synergistic effect on earthworms in the acute toxic test. In long-term toxicity tests, co-exposure of atrazine and monensin also led to worse effects on earthworms including oxidative stress, energy metabolism disruption, and cocoon production compared to single exposure. The expression of tight junction proteins was down-regulated significantly by monensin, indicating that the intestinal barrier of earthworms was weakened, possibly causing the increased bioavailability of atrazine. The expressions of heat shock protein 70 (Hsp70) and reproductive and ontogenetic factors (ANN, TCTP) were all downregulated in binary exposure, indicating that the resilience and cocoon production of earthworms were further weakened under combined pollution. Monensin disturbed the energy metabolism and weakened the intestinal barrier of earthworms. These results showed that monensin increased the risks of atrazine in agricultural areas.

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Ecotoxicity of five veterinary antibiotics on indicator organisms and water and soil communities

Pino-Otín,

Valenzuela,

Gan

et al. 2024

Ecotoxicology and Environmental Safety

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Proteomic analysis of the earthworm Eisenia fetida exposed to oxytetracycline in soil

Abstract: Increasing attention has been paid to the toxicity and hazards of antibiotics on non-target organisms in soil ecosystems as excess antibiotics in the excretion of treated animals are being brought into the soil through manure and sewage irrigation.

Cited by 11 publications

References 37 publications

Environmental and ecotoxicological effects of drugs used for the treatment of COVID 19

Environmental and ecotoxicological effects of drugs used for the treatment of COVID 19

Co-exposure of Monensin Increased the Risks of Atrazine to Earthworms

Ecotoxicity of five veterinary antibiotics on indicator organisms and water and soil communities

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