Proteomic and functional analyses of Lachesis acrochorda snake venom from the Valle del Cauca Department of Colombia

Montoya-Gómez, Alejandro; Osorno-Valencia, Daniel; Gómez-Díaz, Mónica; Bolívar-García, Wilmar; Jiménez-Charris, Eliécer

doi:10.1016/j.actatropica.2023.106895

Cited by 4 publications

(6 citation statements)

References 26 publications

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“…Another study by Montoya-Gómez et al [28] described the qualitative protein family composition of L. acrochorda venom from Valle del Cauca, and detected SVMPs, PLA2s, SVSPs, LAAO, CTL, and NGF. This venom was very different from that reported by Madrigal et al [21], which contained SVMPs, PLA2s, SVSPs, LAAO, Nuc, Hya, PDE, CTL, CRISP, BPP, and VEGF.…”

Section: Proteomic Profiles Of Snake Venoms From Colombiamentioning

confidence: 99%

“…This venom was very different from that reported by Madrigal et al [21], which contained SVMPs, PLA 2s , SVSPs, LAAO, Nuc, Hya, PDE, CTL, CRISP, BPP, and VEGF. The variations between the two venoms were attributed to the different proteomic approaches used, as well as the source of venoms from specimens kept in captivity and from wild animals for the studies of Madrigal et al [21] and Montoya-Gómez et al [28], respectively.…”

Section: Proteomic Profiles Of Snake Venoms From Colombiamentioning

confidence: 99%

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Knowledge about Snake Venoms and Toxins from Colombia: A Systematic Review

Pereañez,

Preciado,

Rey-Suárez

2023

Toxins

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Colombia encompasses three mountain ranges that divide the country into five natural regions: Andes, Pacific, Caribbean, Amazon, and Orinoquia. These regions offer an impressive range of climates, altitudes, and landscapes, which lead to a high snake biodiversity. Of the almost 300 snake species reported in Colombia, nearly 50 are categorized as venomous. This high diversity of species contrasts with the small number of studies to characterize their venom compositions and natural history in the different ecoregions. This work reviews the available information about the venom composition, isolated toxins, and potential applications of snake species found in Colombia. Data compilation was conducted according to the PRISMA guidelines, and the systematic literature search was carried out in Pubmed/MEDLINE. Venom proteomes from nine Viperidae and three Elapidae species have been described using quantitative analytical strategies. In addition, venoms of three Colubridae species have been studied. Bioactivities reported for some of the venoms or isolated components—such as antibacterial, cytotoxicity on tumoral cell lines, and antiplasmodial properties—may be of interest to develop potential applications. Overall, this review indicates that, despite recent progress in the characterization of venoms from several Colombian snakes, it is necessary to perform further studies on the many species whose venoms remain essentially unexplored, especially those of the poorly known genus Micrurus.

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Section: Proteomic Profiles Of Snake Venoms From Colombiamentioning

confidence: 99%

Section: Proteomic Profiles Of Snake Venoms From Colombiamentioning

confidence: 99%

Knowledge about Snake Venoms and Toxins from Colombia: A Systematic Review

Pereañez,

Preciado,

Rey-Suárez

2023

Toxins

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“…The venom comprises 30.6% of SVMPs, 27.1% of Vaso active peptides (VAPs), 21.2% of SVSPs, 14.1% of PLA 2 s, 3.6% of CTLs, and 2.7% of LAAOs. Two components have been isolated from this snake: a non-hemorrhagic SVMP-PI of about 24 kDa named LSF, able to degrade α and β-chains of fibrinogen [ 79 , 80 ], and a PLA 2 of about 13.8 kDa, named LsPA-1, which was not thoroughly studied [ 79 ].…”

Section: Viperidae Familymentioning

confidence: 99%

“…Its name comes from the Greek root of the word acrochordon, which means wart, and this references the warty dorsal scalation that this species presents. Its venom mainly comprises 35.1% of SVSPs, 23.2% of SVMPs, 21.2% of VAPs, 7.9% of CTLs, 2.3% of PLA 2 s, 2.7% of LAAOs, and 1.8% of CRISPs [ 29 , 80 ]. Only one compound is characterized by this venom, a PLA 2 named Lacro_PLA 2 of about 13.97 kDa, involved in edema and myonecrosis effects from the venom [ 81 ].…”

Section: Viperidae Familymentioning

confidence: 99%

“…These enzymes have a variety of pharmacological effects such as anti-coagulant, hemolytic, neurotoxic, myotoxic, edema inducer, hemorrhagic, cytolytic, cardiotoxic, muscarinic inhibitor, platelet anti-aggregant, and anti-coagulant effects [ 90 ]. Recent studies have revealed that PLA 2 s have anti-inflammatory, anti-tumor, and anti-angiogenic activity [ 80 , 90 , 158 ]. Also, snake venoms have some PLA 2 -like toxins, but there is no evidence of an anti-thrombotic activity of these enzymes, and we will not discuss them [ 158 , 159 , 160 ].…”

Section: Potential Biotechnological Applications Of Venom Components ...mentioning

confidence: 99%

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Potential Biotechnological Applications of Venoms from the Viperidae Family in Central America for Thrombosis

Chang Estrada,

Guerrero,

Reyes-Enríquez

et al. 2024

Toxins

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Central America is home to one of the most abundant herpetofauna in the Americas, occupying only 7% of the continent’s total area. Vipers and lizards are among the most relevant venomous animals in medical practice due to the consequences of envenomation from the bite of these animals. A great diversity of biomolecules with immense therapeutic and biotechnological value is contained in their venom. This paper describes the prominent leading representatives of the family Viperidae, emphasizing their morphology, distribution, habitat, feeding, and venom composition, as well as the biotechnological application of some isolated components from the venom of the animals from these families, focusing on molecules with potential anti-thrombotic action. We present the leading protein families that interfere with blood clotting, platelet activity, or the endothelium pro-thrombotic profile. In conclusion, Central America is an endemic region of venomous animals that can provide many molecules for biotechnological applications.

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