Proteomic characterization of the interactions between fish serum proteins and waterborne bacteria reveals the suppression of anti-oxidative defense as a serum-mediated antimicrobial mechanism

Dong, Mingdong; Liang, Yimin; Rajkumar, R.; Tang, Sze Wing; Shen, Wei; Rui, Yong; Gopalakrishnan, Subramaniam; Au, Doris Wai Ting; Lam, Y. W.

doi:10.1016/j.fsi.2017.01.013

Cited by 23 publications

(17 citation statements)

References 42 publications

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“…They may also be classified as FR, since chemical properties give them reactivity to different biological targets, and when in excess they can cause peroxidation of membrane lipids, impairment of proteins in tissues, membranes, enzymes, carbohydrates and DNA. Even though ROS are evolutionarily selected to modulate immunological and physiological processes (Cross et al 1987, Dong et al 2017, Kiley and Storz 2004, Finkel 2011.…”

Section: Oxidative Stressmentioning

confidence: 99%

“…The reactive oxygen species (ROS) produced and the resulting free radicals (FR) are results of normal cell metabolism, and many of these compounds play a key role in various metabolic pathways. Many of these components are essential in the organism defense and their byproducts are considered potent bactericides that act actively in the destruction of invasive pathogens (Cross et al 1987, Dong et al 2017, Biller-Takahashi et al 2015.…”

Section: Introductionmentioning

confidence: 99%

“…The organism during its normal metabolism produces several ROSs, however, it has an antioxidant defense system that keeps the levels of these oxidizing compounds at an acceptable level. In some situations the oxidants production is very high and the cells can suffer serious damage and die (Dong et al 2017, Finkel 2011, Kiley and Storz 2004, Li et al 2016.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress and fish immune system: phagocytosis and leukocyte respiratory burst activity

Biller

Takahashi

2018

An. Acad. Bras. Ciênc.

210

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Molecular oxygen is a necessary compound for all aerobic organisms, although oxygen is a potent oxidant, which can cause oxidative stress (OS). OS occurs when there is an imbalance between the production of oxidant and antioxidants components, are result of normal cell metabolism, and many of these compounds play a fundamental role in several metabolic pathways. The organism produces several reactive oxygen species (ROS), but they are balanced by an antioxidant defense system that maintains the levels of these oxidizing compounds at an acceptable level. Many of these components are essential in the organism defense and their byproducts are considered potent bactericides that actively act in the destruction of invading pathogens. Fish immune system is composed of innate and acquired mechanisms of defense. Phagocytosis is an innate process of defense, which interconnects these two systems, since the pathogens processing by professional phagocytes is a fundamental stage for antibodies production. During phagocytosis there is production of ROS and consequent production of free radicals (FR), these compounds lead to the formation of potent bactericides to combat microorganisms. However, it is known that OS limits the immune response, with an impairment in defense compounds in an attempt to decrease the ROS production. Studies of fish FR production are preliminary and should be executed to evaluate the effects of ROS on fish, including their beneficial action against pathogens and its deleterious action on the oxidation of cellular components.

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Section: Oxidative Stressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oxidative stress and fish immune system: phagocytosis and leukocyte respiratory burst activity

Biller

Takahashi

2018

An. Acad. Bras. Ciênc.

210

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“…However, it disagreed with the reported elevations on PCV, RBC and HB and lowered WBC and PL in fish exposed to a glyphosate based herbicide at short duration (Svodova, 1994). On the contrary, increased total number of leukocytes and platelets could be a defense response in the presence of surfactants and other inert portion of herbicide into the blood stream or as the organism's adaptive response ploy for towards effective immune defense (Barreto-Medeiros et al, 2005;cazenave et al, 2005;Dong et al, 2017;Li et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Haematology, Oxidative Stress and Micronuclei Frequency of Clarias Gariepinus Exposed to Glyphosate based Herbicide Glycot® GBHG

Ezike

Echor

Uwadiegwu

et al. 2019

IJAFAS

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Glyphosate (N-phosphonomethyl glycine) is a broad-spectrum systemic herbicide used extensively in weed control in Nigeria. The present study was designed to evaluate the toxicity effects of glyphosate-Glycot ® on post juveniles (50±1.96g; 22±1.2cm n=300) of Clarias gariepinus exposed to Research Article IJAFAS -An Open Access Journal (ISSN 2348-5132)International Journal of Advanced Fisheries and Aquatic Science 107 potential of C. gariepinus and could serve as an early warning signs toward the avoidance of its ecotoxicological hazards in aquatic ecosystems in Nigeria.

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“…In hermaphroditic orange spotted grouper, beta-defensin isolated from pituitary is mainly expressed in testis [57]. Furthermore, using proteomic approaches, a specific protein from testis, ovary, and brain with antimicrobial activity was identified (IQ motif containing H (IQCH protein)) and found to be greatly stimulated after bacterial infection with Edwardsiella tarda, afterward appearing in serum and binding to bacteria [86]. All these data highlight the role of antimicrobial peptides in the reproductive organs of fish and to the need for further characterization of this activity in the reproductive tract of fish in order to determine potential therapies in the fight against gonad-colonizing pathogens without disturbing the reproductive process.…”

Section: Description Of Antimicrobial Peptidesmentioning

confidence: 99%

Immune-Endocrine Interactions in the Fish Gonad during Infection: An Open Door to Vertical Transmission

Valero

Cuesta

Cammarata

et al. 2018

Fishes

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Abstract:The interaction between the immune and endocrine systems has long been recognized in vertebrates. In fish, it is known that the prevalence and intensity of such infections are higher in males than in females and probably related to sex steroid hormone levels. In addition, the immune response in the fish gonad tissues is specifically regulated to prevent infertility. This condition is used by some pathogens to colonize the fish gonad, evade the systemic immune response, and so spread to the progeny. This review brings up to date our knowledge concerning fish gonad immunity and its regulation, immune-endocrine interactions, and how some pathogens use this tissue to spread to the progeny through vertical transmission. More specifically, we will look at the case of the European sea bass and nodavirus (NNV). Sea bass is a very susceptible fish species to NNV infections, and this virus has been associated to vertical transmission since it is detected in gonad fluids as well as in testicular gametes. In fact, sea bass immunity in the gonad is regulated in a very different way to other target tissues (brain and retina) or immune-relevant tissues (head-kidney or spleen).

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Proteomic characterization of the interactions between fish serum proteins and waterborne bacteria reveals the suppression of anti-oxidative defense as a serum-mediated antimicrobial mechanism

Cited by 23 publications

References 42 publications

Oxidative stress and fish immune system: phagocytosis and leukocyte respiratory burst activity

Oxidative stress and fish immune system: phagocytosis and leukocyte respiratory burst activity

Haematology, Oxidative Stress and Micronuclei Frequency of Clarias Gariepinus Exposed to Glyphosate based Herbicide Glycot® GBHG

Immune-Endocrine Interactions in the Fish Gonad during Infection: An Open Door to Vertical Transmission

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